Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016001200039 |
Resumo: | ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT. |
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Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantationAutologous hematopoietic stem-cell transplantationOxidative stressDNA damageMultiple myelomaLymphomaABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT.Associação Médica Brasileira2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016001200039Revista da Associação Médica Brasileira v.62 suppl.1 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.suppl1.39info:eu-repo/semantics/openAccessSantos,Thayna Nogueira dosDuarte,Fernando BarrosoMaia Filho,Pedro AurioSantos,Talyta Ellen de Jesus dosBarbosa,Maritza CavalcanteAlmeida Filho,Tarcísio Paulo deCavalcanti,Bruno CoelhoVasconcelos,Paulo Roberto Leitão deDutra,Luana LeticiaLopes,Germison SilvaCosta,Franciclea OliveiraLeitão,João Paulo VasconcelosKauFman,JacquesAraúJo,Beatriz Stella PitombeiraBarroso,Karine Sampaio NunesLemes,Romélia Pinheiro Gonçalveseng2016-12-01T00:00:00Zoai:scielo:S0104-42302016001200039Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-12-01T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
title |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
spellingShingle |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation Santos,Thayna Nogueira dos Autologous hematopoietic stem-cell transplantation Oxidative stress DNA damage Multiple myeloma Lymphoma |
title_short |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
title_full |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
title_fullStr |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
title_full_unstemmed |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
title_sort |
Association of oxidative stress and DNA damage with grafting time in patients with multiple myeloma and lymphoma submitted to autologous hematopoietic stem cell transplantation |
author |
Santos,Thayna Nogueira dos |
author_facet |
Santos,Thayna Nogueira dos Duarte,Fernando Barroso Maia Filho,Pedro Aurio Santos,Talyta Ellen de Jesus dos Barbosa,Maritza Cavalcante Almeida Filho,Tarcísio Paulo de Cavalcanti,Bruno Coelho Vasconcelos,Paulo Roberto Leitão de Dutra,Luana Leticia Lopes,Germison Silva Costa,Franciclea Oliveira Leitão,João Paulo Vasconcelos KauFman,Jacques AraúJo,Beatriz Stella Pitombeira Barroso,Karine Sampaio Nunes Lemes,Romélia Pinheiro Gonçalves |
author_role |
author |
author2 |
Duarte,Fernando Barroso Maia Filho,Pedro Aurio Santos,Talyta Ellen de Jesus dos Barbosa,Maritza Cavalcante Almeida Filho,Tarcísio Paulo de Cavalcanti,Bruno Coelho Vasconcelos,Paulo Roberto Leitão de Dutra,Luana Leticia Lopes,Germison Silva Costa,Franciclea Oliveira Leitão,João Paulo Vasconcelos KauFman,Jacques AraúJo,Beatriz Stella Pitombeira Barroso,Karine Sampaio Nunes Lemes,Romélia Pinheiro Gonçalves |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Thayna Nogueira dos Duarte,Fernando Barroso Maia Filho,Pedro Aurio Santos,Talyta Ellen de Jesus dos Barbosa,Maritza Cavalcante Almeida Filho,Tarcísio Paulo de Cavalcanti,Bruno Coelho Vasconcelos,Paulo Roberto Leitão de Dutra,Luana Leticia Lopes,Germison Silva Costa,Franciclea Oliveira Leitão,João Paulo Vasconcelos KauFman,Jacques AraúJo,Beatriz Stella Pitombeira Barroso,Karine Sampaio Nunes Lemes,Romélia Pinheiro Gonçalves |
dc.subject.por.fl_str_mv |
Autologous hematopoietic stem-cell transplantation Oxidative stress DNA damage Multiple myeloma Lymphoma |
topic |
Autologous hematopoietic stem-cell transplantation Oxidative stress DNA damage Multiple myeloma Lymphoma |
description |
ABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were performed at baseline (pre-CR) of the disease and during the conditioning regimen (CR), one day after the HSCT, ten days after HSCT and twenty days after HSCT, as well as in the control group consisting of 30 healthy individuals. The outcomes showed that both groups of patients had an hyperoxidative state with high DI when compared to baseline and to the control group and that the CR exacerbated this condition. However, after the follow-up period of the study, this picture was re-established to the baseline levels of each pathology. The study patients with MM showed a mean grafting time of 10.75 days (8 to 13 days), with 10.15 days (8 to 15 days) for the lymphoma patients. In patients with MM, there was a negative correlation between the grafting time and the basal levels of GPx (r = -0.54; p = 0.034), indicating that lower levels of this important enzyme are associated with a longer grafting time. For the DI, the correlation was a positive one (r = 0.529; p = 0.030). In the group with lymphoma, it was observed that the basal levels of NOx were positively correlated with grafting time (r = 0.4664, p = 0.032). The data indicate the potential of these biomarkers as predictors of toxicity and grafting time in patients with MM and Lymphomas submitted to autologous HSCT. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016001200039 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016001200039 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.62.suppl1.39 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.62 suppl.1 2016 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
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AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
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Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832348471296 |