Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200222 |
Resumo: | SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested. |
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Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort studyAlzheimer diseaseObesityMacronutrientsDementiaSUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested.Associação Médica Brasileira2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200222Revista da Associação Médica Brasileira v.65 n.2 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.2.222info:eu-repo/semantics/openAccessGregório,Elizama dePatrzyk,Luan HenriqueFiebrantz,Anne Karine BosettoBonini,Juliana SartoriCambruzzi,Dayanna HartmannDiedrich,CamilaFermino,Bárbara LuisaFabbri,RobertaSilva,Weber Cláudio Francisco Nunes daeng2019-03-15T00:00:00Zoai:scielo:S0104-42302019000200222Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-03-15T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
title |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
spellingShingle |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study Gregório,Elizama de Alzheimer disease Obesity Macronutrients Dementia |
title_short |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
title_full |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
title_fullStr |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
title_full_unstemmed |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
title_sort |
Nutritional and hematological factors associated with the progression of Alzheimer's disease: a cohort study |
author |
Gregório,Elizama de |
author_facet |
Gregório,Elizama de Patrzyk,Luan Henrique Fiebrantz,Anne Karine Bosetto Bonini,Juliana Sartori Cambruzzi,Dayanna Hartmann Diedrich,Camila Fermino,Bárbara Luisa Fabbri,Roberta Silva,Weber Cláudio Francisco Nunes da |
author_role |
author |
author2 |
Patrzyk,Luan Henrique Fiebrantz,Anne Karine Bosetto Bonini,Juliana Sartori Cambruzzi,Dayanna Hartmann Diedrich,Camila Fermino,Bárbara Luisa Fabbri,Roberta Silva,Weber Cláudio Francisco Nunes da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gregório,Elizama de Patrzyk,Luan Henrique Fiebrantz,Anne Karine Bosetto Bonini,Juliana Sartori Cambruzzi,Dayanna Hartmann Diedrich,Camila Fermino,Bárbara Luisa Fabbri,Roberta Silva,Weber Cláudio Francisco Nunes da |
dc.subject.por.fl_str_mv |
Alzheimer disease Obesity Macronutrients Dementia |
topic |
Alzheimer disease Obesity Macronutrients Dementia |
description |
SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is suggested. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200222 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200222 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.2.222 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.2 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212833854226432 |