Intra-tumor genetic heterogeneity in Wilms tumor samples
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496 |
Resumo: | SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology |
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Intra-tumor genetic heterogeneity in Wilms tumor samplesWilms tumorBiomarkersGenetic HeterogeneitySUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biologyAssociação Médica Brasileira2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496Revista da Associação Médica Brasileira v.65 n.12 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.12.1496info:eu-repo/semantics/openAccessde Sá Pereira,Bruna MAzevedo,Rafaela Montalvão deAguirre Neto,Joaquim Caetano deMenezes,Clarice FrancoRodrigues,Karla EmíliaFaria,Paulo A.Camargo,Beatriz deMaschietto,Marianaeng2020-01-20T00:00:00Zoai:scielo:S0104-42302019001201496Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-01-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
title |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
spellingShingle |
Intra-tumor genetic heterogeneity in Wilms tumor samples de Sá Pereira,Bruna M Wilms tumor Biomarkers Genetic Heterogeneity |
title_short |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
title_full |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
title_fullStr |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
title_full_unstemmed |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
title_sort |
Intra-tumor genetic heterogeneity in Wilms tumor samples |
author |
de Sá Pereira,Bruna M |
author_facet |
de Sá Pereira,Bruna M Azevedo,Rafaela Montalvão de Aguirre Neto,Joaquim Caetano de Menezes,Clarice Franco Rodrigues,Karla Emília Faria,Paulo A. Camargo,Beatriz de Maschietto,Mariana |
author_role |
author |
author2 |
Azevedo,Rafaela Montalvão de Aguirre Neto,Joaquim Caetano de Menezes,Clarice Franco Rodrigues,Karla Emília Faria,Paulo A. Camargo,Beatriz de Maschietto,Mariana |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
de Sá Pereira,Bruna M Azevedo,Rafaela Montalvão de Aguirre Neto,Joaquim Caetano de Menezes,Clarice Franco Rodrigues,Karla Emília Faria,Paulo A. Camargo,Beatriz de Maschietto,Mariana |
dc.subject.por.fl_str_mv |
Wilms tumor Biomarkers Genetic Heterogeneity |
topic |
Wilms tumor Biomarkers Genetic Heterogeneity |
description |
SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.12.1496 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.12 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212834700427264 |