Intra-tumor genetic heterogeneity in Wilms tumor samples

Detalhes bibliográficos
Autor(a) principal: de Sá Pereira,Bruna M
Data de Publicação: 2019
Outros Autores: Azevedo,Rafaela Montalvão de, Aguirre Neto,Joaquim Caetano de, Menezes,Clarice Franco, Rodrigues,Karla Emília, Faria,Paulo A., Camargo,Beatriz de, Maschietto,Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496
Resumo: SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology
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spelling Intra-tumor genetic heterogeneity in Wilms tumor samplesWilms tumorBiomarkersGenetic HeterogeneitySUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biologyAssociação Médica Brasileira2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496Revista da Associação Médica Brasileira v.65 n.12 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.12.1496info:eu-repo/semantics/openAccessde Sá Pereira,Bruna MAzevedo,Rafaela Montalvão deAguirre Neto,Joaquim Caetano deMenezes,Clarice FrancoRodrigues,Karla EmíliaFaria,Paulo A.Camargo,Beatriz deMaschietto,Marianaeng2020-01-20T00:00:00Zoai:scielo:S0104-42302019001201496Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-01-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Intra-tumor genetic heterogeneity in Wilms tumor samples
title Intra-tumor genetic heterogeneity in Wilms tumor samples
spellingShingle Intra-tumor genetic heterogeneity in Wilms tumor samples
de Sá Pereira,Bruna M
Wilms tumor
Biomarkers
Genetic Heterogeneity
title_short Intra-tumor genetic heterogeneity in Wilms tumor samples
title_full Intra-tumor genetic heterogeneity in Wilms tumor samples
title_fullStr Intra-tumor genetic heterogeneity in Wilms tumor samples
title_full_unstemmed Intra-tumor genetic heterogeneity in Wilms tumor samples
title_sort Intra-tumor genetic heterogeneity in Wilms tumor samples
author de Sá Pereira,Bruna M
author_facet de Sá Pereira,Bruna M
Azevedo,Rafaela Montalvão de
Aguirre Neto,Joaquim Caetano de
Menezes,Clarice Franco
Rodrigues,Karla Emília
Faria,Paulo A.
Camargo,Beatriz de
Maschietto,Mariana
author_role author
author2 Azevedo,Rafaela Montalvão de
Aguirre Neto,Joaquim Caetano de
Menezes,Clarice Franco
Rodrigues,Karla Emília
Faria,Paulo A.
Camargo,Beatriz de
Maschietto,Mariana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv de Sá Pereira,Bruna M
Azevedo,Rafaela Montalvão de
Aguirre Neto,Joaquim Caetano de
Menezes,Clarice Franco
Rodrigues,Karla Emília
Faria,Paulo A.
Camargo,Beatriz de
Maschietto,Mariana
dc.subject.por.fl_str_mv Wilms tumor
Biomarkers
Genetic Heterogeneity
topic Wilms tumor
Biomarkers
Genetic Heterogeneity
description SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biology
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019001201496
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.65.12.1496
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.65 n.12 2019
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
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