Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000901174 |
Resumo: | SUMMARY OBJECTIVE The study aims to explore the relationship between preoperative anxiety and chronic postoperative pain. METHODS A total of forty rats were divided into four groups, control, single-prolonged stress alone, Hysterectomy alone, and SPS+ Hysterectomy. The paw withdrawal mechanical thresholds (PWMT) were examined. qRT-PCR and western blotting assay were performed to detect the GFAP expression in astrocytes isolated from the anterior cingulate cortex (ACC) region. In addition, the long-term potentiation (LTP) in ACC was examined. RESULTS Rats in the SPS group or the Hysterectomy alone group had no significant effect on chronic pain formation, but SPS can significantly induce chronic pain after surgery. Astrocytes were still active, and the LTP was significantly increased three days after modeling in the SPS+Hysterectomy group. CONCLUSIONS anxiety can induce chronic pain by activating astrocytes in the ACC region. |
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Revista da Associação Médica Brasileira (Online) |
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Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex regionAnsiedadePain, postoperativeAstrocytesSUMMARY OBJECTIVE The study aims to explore the relationship between preoperative anxiety and chronic postoperative pain. METHODS A total of forty rats were divided into four groups, control, single-prolonged stress alone, Hysterectomy alone, and SPS+ Hysterectomy. The paw withdrawal mechanical thresholds (PWMT) were examined. qRT-PCR and western blotting assay were performed to detect the GFAP expression in astrocytes isolated from the anterior cingulate cortex (ACC) region. In addition, the long-term potentiation (LTP) in ACC was examined. RESULTS Rats in the SPS group or the Hysterectomy alone group had no significant effect on chronic pain formation, but SPS can significantly induce chronic pain after surgery. Astrocytes were still active, and the LTP was significantly increased three days after modeling in the SPS+Hysterectomy group. CONCLUSIONS anxiety can induce chronic pain by activating astrocytes in the ACC region.Associação Médica Brasileira2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000901174Revista da Associação Médica Brasileira v.65 n.9 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.9.1174info:eu-repo/semantics/openAccessGu,DaminZhou,MinminHan,ChaoLei,DaoyunXie,SonghuiYuan,YanboMa,Tieliangeng2019-10-08T00:00:00Zoai:scielo:S0104-42302019000901174Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-10-08T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
title |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
spellingShingle |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region Gu,Damin Ansiedade Pain, postoperative Astrocytes |
title_short |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
title_full |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
title_fullStr |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
title_full_unstemmed |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
title_sort |
Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region |
author |
Gu,Damin |
author_facet |
Gu,Damin Zhou,Minmin Han,Chao Lei,Daoyun Xie,Songhui Yuan,Yanbo Ma,Tieliang |
author_role |
author |
author2 |
Zhou,Minmin Han,Chao Lei,Daoyun Xie,Songhui Yuan,Yanbo Ma,Tieliang |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Gu,Damin Zhou,Minmin Han,Chao Lei,Daoyun Xie,Songhui Yuan,Yanbo Ma,Tieliang |
dc.subject.por.fl_str_mv |
Ansiedade Pain, postoperative Astrocytes |
topic |
Ansiedade Pain, postoperative Astrocytes |
description |
SUMMARY OBJECTIVE The study aims to explore the relationship between preoperative anxiety and chronic postoperative pain. METHODS A total of forty rats were divided into four groups, control, single-prolonged stress alone, Hysterectomy alone, and SPS+ Hysterectomy. The paw withdrawal mechanical thresholds (PWMT) were examined. qRT-PCR and western blotting assay were performed to detect the GFAP expression in astrocytes isolated from the anterior cingulate cortex (ACC) region. In addition, the long-term potentiation (LTP) in ACC was examined. RESULTS Rats in the SPS group or the Hysterectomy alone group had no significant effect on chronic pain formation, but SPS can significantly induce chronic pain after surgery. Astrocytes were still active, and the LTP was significantly increased three days after modeling in the SPS+Hysterectomy group. CONCLUSIONS anxiety can induce chronic pain by activating astrocytes in the ACC region. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000901174 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000901174 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.9.1174 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.9 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
_version_ |
1754212834314551296 |