Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009 |
Resumo: | OBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region. |
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Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon regionCervical cancerCost-effectivenessHuman papillomavirusVaccineBrazilAmazon regionOBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region.Associação Médica Brasileira2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009Revista da Associação Médica Brasileira v.59 n.5 2013reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1016/j.ramb.2013.03.004info:eu-repo/semantics/openAccessFonseca,Allex Jardim daFerreira,Luiz Carlos de LimaBalbinotto Neto,Giacomoeng2015-07-28T00:00:00Zoai:scielo:S0104-42302013000500009Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2015-07-28T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
title |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
spellingShingle |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region Fonseca,Allex Jardim da Cervical cancer Cost-effectiveness Human papillomavirus Vaccine Brazil Amazon region |
title_short |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
title_full |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
title_fullStr |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
title_full_unstemmed |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
title_sort |
Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region |
author |
Fonseca,Allex Jardim da |
author_facet |
Fonseca,Allex Jardim da Ferreira,Luiz Carlos de Lima Balbinotto Neto,Giacomo |
author_role |
author |
author2 |
Ferreira,Luiz Carlos de Lima Balbinotto Neto,Giacomo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Fonseca,Allex Jardim da Ferreira,Luiz Carlos de Lima Balbinotto Neto,Giacomo |
dc.subject.por.fl_str_mv |
Cervical cancer Cost-effectiveness Human papillomavirus Vaccine Brazil Amazon region |
topic |
Cervical cancer Cost-effectiveness Human papillomavirus Vaccine Brazil Amazon region |
description |
OBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.ramb.2013.03.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.59 n.5 2013 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212830785044480 |