Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region

Detalhes bibliográficos
Autor(a) principal: Fonseca,Allex Jardim da
Data de Publicação: 2013
Outros Autores: Ferreira,Luiz Carlos de Lima, Balbinotto Neto,Giacomo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009
Resumo: OBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region.
id AMB-1_e3be86af39b33182582d7dfd18dd477f
oai_identifier_str oai:scielo:S0104-42302013000500009
network_acronym_str AMB-1
network_name_str Revista da Associação Médica Brasileira (Online)
repository_id_str
spelling Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon regionCervical cancerCost-effectivenessHuman papillomavirusVaccineBrazilAmazon regionOBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region.Associação Médica Brasileira2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009Revista da Associação Médica Brasileira v.59 n.5 2013reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1016/j.ramb.2013.03.004info:eu-repo/semantics/openAccessFonseca,Allex Jardim daFerreira,Luiz Carlos de LimaBalbinotto Neto,Giacomoeng2015-07-28T00:00:00Zoai:scielo:S0104-42302013000500009Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2015-07-28T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
title Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
spellingShingle Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
Fonseca,Allex Jardim da
Cervical cancer
Cost-effectiveness
Human papillomavirus
Vaccine
Brazil
Amazon region
title_short Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
title_full Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
title_fullStr Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
title_full_unstemmed Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
title_sort Cost-effectiveness of the vaccine against human papillomavirus in the brazilian Amazon region
author Fonseca,Allex Jardim da
author_facet Fonseca,Allex Jardim da
Ferreira,Luiz Carlos de Lima
Balbinotto Neto,Giacomo
author_role author
author2 Ferreira,Luiz Carlos de Lima
Balbinotto Neto,Giacomo
author2_role author
author
dc.contributor.author.fl_str_mv Fonseca,Allex Jardim da
Ferreira,Luiz Carlos de Lima
Balbinotto Neto,Giacomo
dc.subject.por.fl_str_mv Cervical cancer
Cost-effectiveness
Human papillomavirus
Vaccine
Brazil
Amazon region
topic Cervical cancer
Cost-effectiveness
Human papillomavirus
Vaccine
Brazil
Amazon region
description OBJECTIVE: To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region. METHODS: AMarkov cohort modelwas developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life). RESULTS: The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio. CONCLUSION: Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302013000500009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.ramb.2013.03.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.59 n.5 2013
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
_version_ 1754212830785044480