Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety

Detalhes bibliográficos
Autor(a) principal: Silva Filho,Agnaldo Lopes da
Data de Publicação: 2020
Outros Autores: Carvalho,Gabriella Martins, Sena,Larissa Cristelli de, Gomes,Lívia Passini Guimarães, Valério,Marcos Flávio Habib, Martins,Raíssa Isabelle Leão, Cândido,Eduardo Batista
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801134
Resumo: SUMMARY Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.
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spelling Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safetyMutationEstrogen replacement therapySalpingostomyOvariectomySalpingo-oophorectomyBreast neoplasmsOvarian neoplasmsSUMMARY Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.Associação Médica Brasileira2020-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801134Revista da Associação Médica Brasileira v.66 n.8 2020reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.66.8.1134info:eu-repo/semantics/openAccessSilva Filho,Agnaldo Lopes daCarvalho,Gabriella MartinsSena,Larissa Cristelli deGomes,Lívia Passini GuimarãesValério,Marcos Flávio HabibMartins,Raíssa Isabelle LeãoCândido,Eduardo Batistaeng2020-09-09T00:00:00Zoai:scielo:S0104-42302020000801134Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-09-09T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
title Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
spellingShingle Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
Silva Filho,Agnaldo Lopes da
Mutation
Estrogen replacement therapy
Salpingostomy
Ovariectomy
Salpingo-oophorectomy
Breast neoplasms
Ovarian neoplasms
title_short Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
title_full Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
title_fullStr Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
title_full_unstemmed Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
title_sort Hormone therapy after risk-reducing surgery in patients with BRCA1/BRCA2 mutation: evaluation of potential benefits and safety
author Silva Filho,Agnaldo Lopes da
author_facet Silva Filho,Agnaldo Lopes da
Carvalho,Gabriella Martins
Sena,Larissa Cristelli de
Gomes,Lívia Passini Guimarães
Valério,Marcos Flávio Habib
Martins,Raíssa Isabelle Leão
Cândido,Eduardo Batista
author_role author
author2 Carvalho,Gabriella Martins
Sena,Larissa Cristelli de
Gomes,Lívia Passini Guimarães
Valério,Marcos Flávio Habib
Martins,Raíssa Isabelle Leão
Cândido,Eduardo Batista
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva Filho,Agnaldo Lopes da
Carvalho,Gabriella Martins
Sena,Larissa Cristelli de
Gomes,Lívia Passini Guimarães
Valério,Marcos Flávio Habib
Martins,Raíssa Isabelle Leão
Cândido,Eduardo Batista
dc.subject.por.fl_str_mv Mutation
Estrogen replacement therapy
Salpingostomy
Ovariectomy
Salpingo-oophorectomy
Breast neoplasms
Ovarian neoplasms
topic Mutation
Estrogen replacement therapy
Salpingostomy
Ovariectomy
Salpingo-oophorectomy
Breast neoplasms
Ovarian neoplasms
description SUMMARY Women with mutations in the BRCA 1 and 2 genes are at increased risk for ovarian and breast cancer and therefore candidates for risk-reducing surgery, including salpingo-oophorectomy and mastectomy. Risk-reducing salpingo-oophorectomy (RRSO) is considered the most effective prophylactic measure for ovarian cancer prevention in this group of patients. This procedure involves loss of ovarian function and induced menopause. Estrogen therapy is the most effective treatment for controlling vasomotor symptoms and improving the quality of life of climacteric women. However, the potential hormonal stimulation of these tumors and the risk of breast cancer are a concern regarding the safety of hormone replacement therapy (HRT) in this population. This article aims to review the current evidence regarding the potential benefits and safety of HRT after RRSO.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801134
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020000801134
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.66.8.1134
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.66 n.8 2020
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
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