Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital

Detalhes bibliográficos
Autor(a) principal: Silveira,Felipe
Data de Publicação: 2017
Outros Autores: Basile,Maíra Leite, Kuga,Fábio Seiji, Próspero,José Donato, Paes,Roberto Antonio Pinto, Bernardi,Fabíola Del Carlo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017001000856
Resumo: Summary Objective: To compare the frequency of neuroendocrine tumors in our service with that reported in the literature considering age, gender, location, degree of differentiation and increase in incidence by means of a retrospective study. Method: Search of variables from a database of neuroendocrine tumor cases diagnosed at the Department of Pathological Sciences, Hospital da Santa Casa de São Paulo over the past 10 years, relating them to epidemiological data such as gender, age, distribution across organs, most-used immunohistochemical markers and presence or absence of either lymph node or distant metastases. Results: In all, 250 cases were reviewed, 133 involving females, predominantly in the 61-70 age range. The lung was the most frequent site, followed by the stomach. CD56, synaptophysin and chromogranin were the immunohistochemical markers used most often and to a lesser extent Ki67, a marker of cell proliferation that indicates a higher or lower degree of histological malignancy. Metastases, either in lymph nodes and/or distant sites, were found in 44 cases (17.6%). Conclusion: The results were largely consistent with those in the literature, including age group, gender and location. Most metastases originated from high-grade tumors, with high Ki67 levels and greater impairment of the liver. However, only 36.4% of the cases had Ki67 index. Reevaluation of the Ki67 proliferative index using image analysis in doubtful cases will allow for a correlation between progression and prognosis.
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spelling Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospitalneuroendocrine tumors/epidemiologyneoplasmsepidemiologic studiesSummary Objective: To compare the frequency of neuroendocrine tumors in our service with that reported in the literature considering age, gender, location, degree of differentiation and increase in incidence by means of a retrospective study. Method: Search of variables from a database of neuroendocrine tumor cases diagnosed at the Department of Pathological Sciences, Hospital da Santa Casa de São Paulo over the past 10 years, relating them to epidemiological data such as gender, age, distribution across organs, most-used immunohistochemical markers and presence or absence of either lymph node or distant metastases. Results: In all, 250 cases were reviewed, 133 involving females, predominantly in the 61-70 age range. The lung was the most frequent site, followed by the stomach. CD56, synaptophysin and chromogranin were the immunohistochemical markers used most often and to a lesser extent Ki67, a marker of cell proliferation that indicates a higher or lower degree of histological malignancy. Metastases, either in lymph nodes and/or distant sites, were found in 44 cases (17.6%). Conclusion: The results were largely consistent with those in the literature, including age group, gender and location. Most metastases originated from high-grade tumors, with high Ki67 levels and greater impairment of the liver. However, only 36.4% of the cases had Ki67 index. Reevaluation of the Ki67 proliferative index using image analysis in doubtful cases will allow for a correlation between progression and prognosis.Associação Médica Brasileira2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017001000856Revista da Associação Médica Brasileira v.63 n.10 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.10.856info:eu-repo/semantics/openAccessSilveira,FelipeBasile,Maíra LeiteKuga,Fábio SeijiPróspero,José DonatoPaes,Roberto Antonio PintoBernardi,Fabíola Del Carloeng2017-12-11T00:00:00Zoai:scielo:S0104-42302017001000856Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-12-11T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
title Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
spellingShingle Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
Silveira,Felipe
neuroendocrine tumors/epidemiology
neoplasms
epidemiologic studies
title_short Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
title_full Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
title_fullStr Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
title_full_unstemmed Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
title_sort Neuroendocrine tumors: An epidemiological study of 250 cases at a tertiary hospital
author Silveira,Felipe
author_facet Silveira,Felipe
Basile,Maíra Leite
Kuga,Fábio Seiji
Próspero,José Donato
Paes,Roberto Antonio Pinto
Bernardi,Fabíola Del Carlo
author_role author
author2 Basile,Maíra Leite
Kuga,Fábio Seiji
Próspero,José Donato
Paes,Roberto Antonio Pinto
Bernardi,Fabíola Del Carlo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silveira,Felipe
Basile,Maíra Leite
Kuga,Fábio Seiji
Próspero,José Donato
Paes,Roberto Antonio Pinto
Bernardi,Fabíola Del Carlo
dc.subject.por.fl_str_mv neuroendocrine tumors/epidemiology
neoplasms
epidemiologic studies
topic neuroendocrine tumors/epidemiology
neoplasms
epidemiologic studies
description Summary Objective: To compare the frequency of neuroendocrine tumors in our service with that reported in the literature considering age, gender, location, degree of differentiation and increase in incidence by means of a retrospective study. Method: Search of variables from a database of neuroendocrine tumor cases diagnosed at the Department of Pathological Sciences, Hospital da Santa Casa de São Paulo over the past 10 years, relating them to epidemiological data such as gender, age, distribution across organs, most-used immunohistochemical markers and presence or absence of either lymph node or distant metastases. Results: In all, 250 cases were reviewed, 133 involving females, predominantly in the 61-70 age range. The lung was the most frequent site, followed by the stomach. CD56, synaptophysin and chromogranin were the immunohistochemical markers used most often and to a lesser extent Ki67, a marker of cell proliferation that indicates a higher or lower degree of histological malignancy. Metastases, either in lymph nodes and/or distant sites, were found in 44 cases (17.6%). Conclusion: The results were largely consistent with those in the literature, including age group, gender and location. Most metastases originated from high-grade tumors, with high Ki67 levels and greater impairment of the liver. However, only 36.4% of the cases had Ki67 index. Reevaluation of the Ki67 proliferative index using image analysis in doubtful cases will allow for a correlation between progression and prognosis.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
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dc.relation.none.fl_str_mv 10.1590/1806-9282.63.10.856
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.63 n.10 2017
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