Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000400336 |
Resumo: | Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals with liver cirrhosis, observing macroscopic and microscopic changes in lipid and collagen deposits and in the liver. We also aimed to verify the association of lipid and collagen fiber deposits with gender, age and body mass index, and to relate alcoholism, liver cirrhosis and atherosclerosis. Method: We performed a study based on autopsy reports of patients with alcoholic liver cirrhosis, with analysis of aorta and liver fragments to verify the occurrence and degree of atherosclerosis, as well as collagen contents. Results: Microscopic atherosclerosis was higher in young subjects (early injury) and in patients with alcoholic liver cirrhosis. The macroscopic analysis of atherosclerosis in aortas showed that patients in more advanced age groups presented more severe classifications. Atherosclerosis, both micro and macroscopically, and the percentage of fibrosis in the liver and aorta were more expressive in females. Conclusion: Cirrhotic patients presented a higher percentage of fibrosis and lipidosis, and may represent a group susceptible to the accelerated progression of cardiovascular diseases. Investigative studies contribute to targeting health-promoting interventions, reducing the mortality and costs of treating cardiovascular disease. |
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Implications of alcoholic cirrhosis in atherosclerosis of autopsied patientsatherosclerosisalcoholic liver cirrhosisautopsySummary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals with liver cirrhosis, observing macroscopic and microscopic changes in lipid and collagen deposits and in the liver. We also aimed to verify the association of lipid and collagen fiber deposits with gender, age and body mass index, and to relate alcoholism, liver cirrhosis and atherosclerosis. Method: We performed a study based on autopsy reports of patients with alcoholic liver cirrhosis, with analysis of aorta and liver fragments to verify the occurrence and degree of atherosclerosis, as well as collagen contents. Results: Microscopic atherosclerosis was higher in young subjects (early injury) and in patients with alcoholic liver cirrhosis. The macroscopic analysis of atherosclerosis in aortas showed that patients in more advanced age groups presented more severe classifications. Atherosclerosis, both micro and macroscopically, and the percentage of fibrosis in the liver and aorta were more expressive in females. Conclusion: Cirrhotic patients presented a higher percentage of fibrosis and lipidosis, and may represent a group susceptible to the accelerated progression of cardiovascular diseases. Investigative studies contribute to targeting health-promoting interventions, reducing the mortality and costs of treating cardiovascular disease.Associação Médica Brasileira2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000400336Revista da Associação Médica Brasileira v.63 n.4 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.04.336info:eu-repo/semantics/openAccessSilveira,Luciano Alves Matias daTorquato,Bianca Gonçalves SilvaOliveira,Mariana SilvaJuliano,Guilherme RibeiroOliveira,Lívia FerreiraCavellani,Camila LourenciniRamalho,Luciana SantosEspindula,Ana PaulaTeixeira,Vicente de Paula AntunesFerraz,Mara Lúcia Fonsecaeng2017-06-08T00:00:00Zoai:scielo:S0104-42302017000400336Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2017-06-08T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
title |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
spellingShingle |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients Silveira,Luciano Alves Matias da atherosclerosis alcoholic liver cirrhosis autopsy |
title_short |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
title_full |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
title_fullStr |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
title_full_unstemmed |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
title_sort |
Implications of alcoholic cirrhosis in atherosclerosis of autopsied patients |
author |
Silveira,Luciano Alves Matias da |
author_facet |
Silveira,Luciano Alves Matias da Torquato,Bianca Gonçalves Silva Oliveira,Mariana Silva Juliano,Guilherme Ribeiro Oliveira,Lívia Ferreira Cavellani,Camila Lourencini Ramalho,Luciana Santos Espindula,Ana Paula Teixeira,Vicente de Paula Antunes Ferraz,Mara Lúcia Fonseca |
author_role |
author |
author2 |
Torquato,Bianca Gonçalves Silva Oliveira,Mariana Silva Juliano,Guilherme Ribeiro Oliveira,Lívia Ferreira Cavellani,Camila Lourencini Ramalho,Luciana Santos Espindula,Ana Paula Teixeira,Vicente de Paula Antunes Ferraz,Mara Lúcia Fonseca |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silveira,Luciano Alves Matias da Torquato,Bianca Gonçalves Silva Oliveira,Mariana Silva Juliano,Guilherme Ribeiro Oliveira,Lívia Ferreira Cavellani,Camila Lourencini Ramalho,Luciana Santos Espindula,Ana Paula Teixeira,Vicente de Paula Antunes Ferraz,Mara Lúcia Fonseca |
dc.subject.por.fl_str_mv |
atherosclerosis alcoholic liver cirrhosis autopsy |
topic |
atherosclerosis alcoholic liver cirrhosis autopsy |
description |
Summary Introduction: Alcoholism is a major public health problem, which has a high social cost and affects many aspects of human activity. Liver disease is one of the first consequences of alcohol abuse, and steatosis, liver cirrhosis and hepatitis may occur. Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. Objective: To identify the occurrence and degree of atherosclerosis in alcohol-dependent individuals with liver cirrhosis, observing macroscopic and microscopic changes in lipid and collagen deposits and in the liver. We also aimed to verify the association of lipid and collagen fiber deposits with gender, age and body mass index, and to relate alcoholism, liver cirrhosis and atherosclerosis. Method: We performed a study based on autopsy reports of patients with alcoholic liver cirrhosis, with analysis of aorta and liver fragments to verify the occurrence and degree of atherosclerosis, as well as collagen contents. Results: Microscopic atherosclerosis was higher in young subjects (early injury) and in patients with alcoholic liver cirrhosis. The macroscopic analysis of atherosclerosis in aortas showed that patients in more advanced age groups presented more severe classifications. Atherosclerosis, both micro and macroscopically, and the percentage of fibrosis in the liver and aorta were more expressive in females. Conclusion: Cirrhotic patients presented a higher percentage of fibrosis and lipidosis, and may represent a group susceptible to the accelerated progression of cardiovascular diseases. Investigative studies contribute to targeting health-promoting interventions, reducing the mortality and costs of treating cardiovascular disease. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000400336 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000400336 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.63.04.336 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.63 n.4 2017 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832432357376 |