Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report

Detalhes bibliográficos
Autor(a) principal: Damin,Antonio Eduardo
Data de Publicação: 2009
Outros Autores: Morillo,Lílian S., Perroco,Tíbor Rilho, Jacob Filho,Wilson, Bottino,Cássio Machado de Campos
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100068
Resumo: Abstract Cognitive decline associated with radiotherapy is a progressive complication that affects many patients submitted to this form of treatment. The lack of an effective treatment drives research for new treatment options to improve the quality of life of patients with this disorder. We report the case of a 64 year-old man who developed a severe dementia of the frontal subcortical type, which was associated with subcortical frontal lesions and appeared as a late complication of radiotherapy used to treat a pituitary tumor. After many pharmacological attempts to improve his cognitive and behavioral problems, the patient showed a significant improvement in the cognitive, functional and behavioral impairments after treatment with an acetylcholinesterase inhibitor. This report discusses hypotheses for the positive effect of this treatment.
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spelling Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case reportdementiatherapeuticsradiotherapycholinesterase inhibitors.Abstract Cognitive decline associated with radiotherapy is a progressive complication that affects many patients submitted to this form of treatment. The lack of an effective treatment drives research for new treatment options to improve the quality of life of patients with this disorder. We report the case of a 64 year-old man who developed a severe dementia of the frontal subcortical type, which was associated with subcortical frontal lesions and appeared as a late complication of radiotherapy used to treat a pituitary tumor. After many pharmacological attempts to improve his cognitive and behavioral problems, the patient showed a significant improvement in the cognitive, functional and behavioral impairments after treatment with an acetylcholinesterase inhibitor. This report discusses hypotheses for the positive effect of this treatment.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2009-03-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100068Dementia & Neuropsychologia v.3 n.1 2009reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN30100013info:eu-repo/semantics/openAccessDamin,Antonio EduardoMorillo,Lílian S.Perroco,Tíbor RilhoJacob Filho,WilsonBottino,Cássio Machado de Camposeng2016-07-29T00:00:00Zoai:scielo:S1980-57642009000100068Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-29T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
title Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
spellingShingle Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
Damin,Antonio Eduardo
dementia
therapeutics
radiotherapy
cholinesterase inhibitors.
title_short Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
title_full Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
title_fullStr Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
title_full_unstemmed Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
title_sort Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor A case report
author Damin,Antonio Eduardo
author_facet Damin,Antonio Eduardo
Morillo,Lílian S.
Perroco,Tíbor Rilho
Jacob Filho,Wilson
Bottino,Cássio Machado de Campos
author_role author
author2 Morillo,Lílian S.
Perroco,Tíbor Rilho
Jacob Filho,Wilson
Bottino,Cássio Machado de Campos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Damin,Antonio Eduardo
Morillo,Lílian S.
Perroco,Tíbor Rilho
Jacob Filho,Wilson
Bottino,Cássio Machado de Campos
dc.subject.por.fl_str_mv dementia
therapeutics
radiotherapy
cholinesterase inhibitors.
topic dementia
therapeutics
radiotherapy
cholinesterase inhibitors.
description Abstract Cognitive decline associated with radiotherapy is a progressive complication that affects many patients submitted to this form of treatment. The lack of an effective treatment drives research for new treatment options to improve the quality of life of patients with this disorder. We report the case of a 64 year-old man who developed a severe dementia of the frontal subcortical type, which was associated with subcortical frontal lesions and appeared as a late complication of radiotherapy used to treat a pituitary tumor. After many pharmacological attempts to improve his cognitive and behavioral problems, the patient showed a significant improvement in the cognitive, functional and behavioral impairments after treatment with an acetylcholinesterase inhibitor. This report discusses hypotheses for the positive effect of this treatment.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100068
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100068
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642009DN30100013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.3 n.1 2009
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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