Cognitive impairment in Wilson's disease
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Dementia & Neuropsychologia |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100016 |
Summary: | Abstract Wilson's disease (WD) or hepatolenticular degeneration is a rare, genetic and systemic disease, caused by a deficit in the metabolism of copper, leading to its accumulation in different organs, mainly the liver, followed by the central nervous system, especially the basal ganglia. When symptoms begin between the second and third decades of life, approximately 50% of the patients show neurological symptoms. Although dystonia and dysarthria are the most common neurological signs, cognitive changes have been reported since the first cases were described in 1912. Memory change is one of the most common impairments, but other cognitive changes have been reported, including dementia in untreated cases. In this article we review the cognitive changes in WD patients and the occurrence of dementia. |
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Cognitive impairment in Wilson's diseaseWilson's diseasecognitiondementia.Abstract Wilson's disease (WD) or hepatolenticular degeneration is a rare, genetic and systemic disease, caused by a deficit in the metabolism of copper, leading to its accumulation in different organs, mainly the liver, followed by the central nervous system, especially the basal ganglia. When symptoms begin between the second and third decades of life, approximately 50% of the patients show neurological symptoms. Although dystonia and dysarthria are the most common neurological signs, cognitive changes have been reported since the first cases were described in 1912. Memory change is one of the most common impairments, but other cognitive changes have been reported, including dementia in untreated cases. In this article we review the cognitive changes in WD patients and the occurrence of dementia.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100016Dementia & Neuropsychologia v.3 n.1 2009reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN30100004info:eu-repo/semantics/openAccessFrota,Norberto Anizio FerreiraCaramelli,PauloBarbosa,Egberto Reiseng2016-07-29T00:00:00Zoai:scielo:S1980-57642009000100016Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-29T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Cognitive impairment in Wilson's disease |
title |
Cognitive impairment in Wilson's disease |
spellingShingle |
Cognitive impairment in Wilson's disease Frota,Norberto Anizio Ferreira Wilson's disease cognition dementia. |
title_short |
Cognitive impairment in Wilson's disease |
title_full |
Cognitive impairment in Wilson's disease |
title_fullStr |
Cognitive impairment in Wilson's disease |
title_full_unstemmed |
Cognitive impairment in Wilson's disease |
title_sort |
Cognitive impairment in Wilson's disease |
author |
Frota,Norberto Anizio Ferreira |
author_facet |
Frota,Norberto Anizio Ferreira Caramelli,Paulo Barbosa,Egberto Reis |
author_role |
author |
author2 |
Caramelli,Paulo Barbosa,Egberto Reis |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Frota,Norberto Anizio Ferreira Caramelli,Paulo Barbosa,Egberto Reis |
dc.subject.por.fl_str_mv |
Wilson's disease cognition dementia. |
topic |
Wilson's disease cognition dementia. |
description |
Abstract Wilson's disease (WD) or hepatolenticular degeneration is a rare, genetic and systemic disease, caused by a deficit in the metabolism of copper, leading to its accumulation in different organs, mainly the liver, followed by the central nervous system, especially the basal ganglia. When symptoms begin between the second and third decades of life, approximately 50% of the patients show neurological symptoms. Although dystonia and dysarthria are the most common neurological signs, cognitive changes have been reported since the first cases were described in 1912. Memory change is one of the most common impairments, but other cognitive changes have been reported, including dementia in untreated cases. In this article we review the cognitive changes in WD patients and the occurrence of dementia. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1980-57642009DN30100004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.3 n.1 2009 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
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1754212929607041024 |