Diagnostic relevance of spatial orientation for vascular dementia: A case study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642018000100085 |
Resumo: | ABSTRACT Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology. |
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Dementia & Neuropsychologia |
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Diagnostic relevance of spatial orientation for vascular dementia: A case studyspatial orientationegocentricallocentricvascular dementiaVaDexecutive functionneurodegenerationABSTRACT Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2018-03-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642018000100085Dementia & Neuropsychologia v.12 n.1 2018reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/1980-57642018dn12-010013info:eu-repo/semantics/openAccessCoughlan,GillianFlanagan,EmmaJeffs,StephenBertoux,MaximeSpiers,HugoMioshi,EneidaHornberger,Michaeleng2018-04-12T00:00:00Zoai:scielo:S1980-57642018000100085Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2018-04-12T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
title |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
spellingShingle |
Diagnostic relevance of spatial orientation for vascular dementia: A case study Coughlan,Gillian spatial orientation egocentric allocentric vascular dementia VaD executive function neurodegeneration |
title_short |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
title_full |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
title_fullStr |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
title_full_unstemmed |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
title_sort |
Diagnostic relevance of spatial orientation for vascular dementia: A case study |
author |
Coughlan,Gillian |
author_facet |
Coughlan,Gillian Flanagan,Emma Jeffs,Stephen Bertoux,Maxime Spiers,Hugo Mioshi,Eneida Hornberger,Michael |
author_role |
author |
author2 |
Flanagan,Emma Jeffs,Stephen Bertoux,Maxime Spiers,Hugo Mioshi,Eneida Hornberger,Michael |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Coughlan,Gillian Flanagan,Emma Jeffs,Stephen Bertoux,Maxime Spiers,Hugo Mioshi,Eneida Hornberger,Michael |
dc.subject.por.fl_str_mv |
spatial orientation egocentric allocentric vascular dementia VaD executive function neurodegeneration |
topic |
spatial orientation egocentric allocentric vascular dementia VaD executive function neurodegeneration |
description |
ABSTRACT Spatial orientation is emerging as an early and reliable cognitive biomarker of Alzheimer’s disease (AD) pathophysiology. However, no evidence exists as to whether spatial orientation is also affected in vascular dementia (VaD). Objective: To examine allocentric (map-based) and egocentric (viewpoint-based) spatial orientation in an early stage VaD case. Methods: A spatial test battery was administered following clinical and neuropsychological cognitive evaluation. Results: Despite the patient’s complaints, little evidence of episodic memory deficits were detected when cueing was provided to overcome executive dysfunction. Similarly, medial temporal lobe-mediated allocentric orientation was intact. By contrast, medial parietal-mediated egocentric orientation was impaired, despite normal performance on standard visuospatial tasks. Conclusion: To our knowledge, this is the first in-depth investigation of spatial orientation deficits in VaD. Isolated egocentric deficits were observed. This differs from AD orientation deficits which encompass both allocentric and egocentric orientation deficits. A combination of egocentric orientation and executive function tests could serve as a promising cognitive marker for VaD pathophysiology. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642018000100085 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642018000100085 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-57642018dn12-010013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.12 n.1 2018 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
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1754212931824779264 |