Cognitive impairment in Spinocerebellar ataxia type 10

Detalhes bibliográficos
Autor(a) principal: Moro,Adriana
Data de Publicação: 2016
Outros Autores: Teive,Hélio Afonso Ghizoni
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000400310
Resumo: ABSTRACT Background: Cognitive and psychiatric dysfunction has been described in several neurodegenerative diseases but has not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). Objective: The aim of the present study was to investigate the core cognitive features in a large cohort of Brazilian patients with SCA10, comparing the results against a healthy control group. Methods: Twenty-eight SCA10 and 28 healthy subjects were prospectively assessed regarding cognitive function and psychiatric disorders at the Movement Disorders Unit of the Federal University of Paraná between February 2012 and October 2014. Results: The SCA10 group had worse depression scores, as well as cognitive performance, when compared to healthy individuals. Conclusion: Our study showed mild cognitive and mood dysfunctions in patients with SCA10, consistent with the symptoms reported in the Cerebellar Cognitive Affective Syndrome described by Schmahmann JD in 1998. The description of these findings is an important clinical phenomenon that may guide physicians in specific disease management and improve quality of life of these patients.
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spelling Cognitive impairment in Spinocerebellar ataxia type 10spinocerebellar ataxia type 10cognitive dysfunctionpsychiatricneuropsychologicalABSTRACT Background: Cognitive and psychiatric dysfunction has been described in several neurodegenerative diseases but has not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). Objective: The aim of the present study was to investigate the core cognitive features in a large cohort of Brazilian patients with SCA10, comparing the results against a healthy control group. Methods: Twenty-eight SCA10 and 28 healthy subjects were prospectively assessed regarding cognitive function and psychiatric disorders at the Movement Disorders Unit of the Federal University of Paraná between February 2012 and October 2014. Results: The SCA10 group had worse depression scores, as well as cognitive performance, when compared to healthy individuals. Conclusion: Our study showed mild cognitive and mood dysfunctions in patients with SCA10, consistent with the symptoms reported in the Cerebellar Cognitive Affective Syndrome described by Schmahmann JD in 1998. The description of these findings is an important clinical phenomenon that may guide physicians in specific disease management and improve quality of life of these patients.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000400310Dementia & Neuropsychologia v.10 n.4 2016reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/s1980-5764-2016dn1004009info:eu-repo/semantics/openAccessMoro,AdrianaTeive,Hélio Afonso Ghizonieng2016-12-19T00:00:00Zoai:scielo:S1980-57642016000400310Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-12-19T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Cognitive impairment in Spinocerebellar ataxia type 10
title Cognitive impairment in Spinocerebellar ataxia type 10
spellingShingle Cognitive impairment in Spinocerebellar ataxia type 10
Moro,Adriana
spinocerebellar ataxia type 10
cognitive dysfunction
psychiatric
neuropsychological
title_short Cognitive impairment in Spinocerebellar ataxia type 10
title_full Cognitive impairment in Spinocerebellar ataxia type 10
title_fullStr Cognitive impairment in Spinocerebellar ataxia type 10
title_full_unstemmed Cognitive impairment in Spinocerebellar ataxia type 10
title_sort Cognitive impairment in Spinocerebellar ataxia type 10
author Moro,Adriana
author_facet Moro,Adriana
Teive,Hélio Afonso Ghizoni
author_role author
author2 Teive,Hélio Afonso Ghizoni
author2_role author
dc.contributor.author.fl_str_mv Moro,Adriana
Teive,Hélio Afonso Ghizoni
dc.subject.por.fl_str_mv spinocerebellar ataxia type 10
cognitive dysfunction
psychiatric
neuropsychological
topic spinocerebellar ataxia type 10
cognitive dysfunction
psychiatric
neuropsychological
description ABSTRACT Background: Cognitive and psychiatric dysfunction has been described in several neurodegenerative diseases but has not been systematically evaluated in spinocerebellar ataxia type 10 (SCA10). Objective: The aim of the present study was to investigate the core cognitive features in a large cohort of Brazilian patients with SCA10, comparing the results against a healthy control group. Methods: Twenty-eight SCA10 and 28 healthy subjects were prospectively assessed regarding cognitive function and psychiatric disorders at the Movement Disorders Unit of the Federal University of Paraná between February 2012 and October 2014. Results: The SCA10 group had worse depression scores, as well as cognitive performance, when compared to healthy individuals. Conclusion: Our study showed mild cognitive and mood dysfunctions in patients with SCA10, consistent with the symptoms reported in the Cerebellar Cognitive Affective Syndrome described by Schmahmann JD in 1998. The description of these findings is an important clinical phenomenon that may guide physicians in specific disease management and improve quality of life of these patients.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000400310
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000400310
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1980-5764-2016dn1004009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.10 n.4 2016
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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