Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging

Detalhes bibliográficos
Autor(a) principal: Souza-Talarico,Juliana Nery de
Data de Publicação: 2011
Outros Autores: Marin,Marie-France, Sindi,Shireen, Lupien,Sonia J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008
Resumo: Abstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain's vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer's disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia.
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spelling Effects of stress hormones on the brain and cognition: Evidence from normal to pathological agingglucocorticoidsmemoryagingAlzheimer's diseaseAbstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain's vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer's disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2011-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008Dementia & Neuropsychologia v.5 n.1 2011reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642011DN05010003info:eu-repo/semantics/openAccessSouza-Talarico,Juliana Nery deMarin,Marie-FranceSindi,ShireenLupien,Sonia J.eng2016-07-25T00:00:00Zoai:scielo:S1980-57642011000100008Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-25T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
title Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
spellingShingle Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
Souza-Talarico,Juliana Nery de
glucocorticoids
memory
aging
Alzheimer's disease
title_short Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
title_full Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
title_fullStr Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
title_full_unstemmed Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
title_sort Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging
author Souza-Talarico,Juliana Nery de
author_facet Souza-Talarico,Juliana Nery de
Marin,Marie-France
Sindi,Shireen
Lupien,Sonia J.
author_role author
author2 Marin,Marie-France
Sindi,Shireen
Lupien,Sonia J.
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza-Talarico,Juliana Nery de
Marin,Marie-France
Sindi,Shireen
Lupien,Sonia J.
dc.subject.por.fl_str_mv glucocorticoids
memory
aging
Alzheimer's disease
topic glucocorticoids
memory
aging
Alzheimer's disease
description Abstract Several studies have demonstrated a wide cognitive variability among aged individuals. One factor thought to be associated with this heterogeneity is exposure to chronic stress throughout life. Animal and human evidence demonstrates that glucocorticoids (GCs), the main class of stress hormones, are strongly linked to memory performance whereby elevated GC levels are associated with memory performance decline in both normal and pathological cognitive aging. Accordingly, it is believed that GCs may increase the brain's vulnerability to the effects of internal and external insults, and thus may play a role in the development of age-related cognitive disorders such as Alzheimer's disease (AD). The aim of this review article was to investigate the effects of GCs on normal and pathological cognitive aging by showing how these hormones interact with different brain structures involved in cognitive abilities, subsequently worsen memory performance, and increase the risk for developing dementia.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642011000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642011DN05010003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.5 n.1 2011
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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