Neuropathology of frontotemporal lobar degeneration: A review

Detalhes bibliográficos
Autor(a) principal: Bahia,Valéria Santoro
Data de Publicação: 2013
Outros Autores: Takada,Leonel Tadao, Deramecourt,Vincent
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100019
Resumo: ABSTRACT Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA). FTLD represents a highly heterogeneous group of neurodegenerative disorders which are best classified according to the main protein component of pathological neuronal and glial inclusions. The most common pathological class of FTLD is associated with the TDP-43 protein (FTLD-TDP), while FTLD-Tau is considered slightly less common while the FTLD-FUS (Fused in sarcoma protein) pathology is rare. In this review, these three major pathological types of FTLD are discussed.
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spelling Neuropathology of frontotemporal lobar degeneration: A reviewfrontotemporal lobar degenerationpathologyTAUTDPFUSABSTRACT Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA). FTLD represents a highly heterogeneous group of neurodegenerative disorders which are best classified according to the main protein component of pathological neuronal and glial inclusions. The most common pathological class of FTLD is associated with the TDP-43 protein (FTLD-TDP), while FTLD-Tau is considered slightly less common while the FTLD-FUS (Fused in sarcoma protein) pathology is rare. In this review, these three major pathological types of FTLD are discussed.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100019Dementia & Neuropsychologia v.7 n.1 2013reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642013DN70100004info:eu-repo/semantics/openAccessBahia,Valéria SantoroTakada,Leonel TadaoDeramecourt,Vincenteng2016-06-16T00:00:00Zoai:scielo:S1980-57642013000100019Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-06-16T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Neuropathology of frontotemporal lobar degeneration: A review
title Neuropathology of frontotemporal lobar degeneration: A review
spellingShingle Neuropathology of frontotemporal lobar degeneration: A review
Bahia,Valéria Santoro
frontotemporal lobar degeneration
pathology
TAU
TDP
FUS
title_short Neuropathology of frontotemporal lobar degeneration: A review
title_full Neuropathology of frontotemporal lobar degeneration: A review
title_fullStr Neuropathology of frontotemporal lobar degeneration: A review
title_full_unstemmed Neuropathology of frontotemporal lobar degeneration: A review
title_sort Neuropathology of frontotemporal lobar degeneration: A review
author Bahia,Valéria Santoro
author_facet Bahia,Valéria Santoro
Takada,Leonel Tadao
Deramecourt,Vincent
author_role author
author2 Takada,Leonel Tadao
Deramecourt,Vincent
author2_role author
author
dc.contributor.author.fl_str_mv Bahia,Valéria Santoro
Takada,Leonel Tadao
Deramecourt,Vincent
dc.subject.por.fl_str_mv frontotemporal lobar degeneration
pathology
TAU
TDP
FUS
topic frontotemporal lobar degeneration
pathology
TAU
TDP
FUS
description ABSTRACT Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD) and progressive non-fluent aphasia (PNFA). FTLD represents a highly heterogeneous group of neurodegenerative disorders which are best classified according to the main protein component of pathological neuronal and glial inclusions. The most common pathological class of FTLD is associated with the TDP-43 protein (FTLD-TDP), while FTLD-Tau is considered slightly less common while the FTLD-FUS (Fused in sarcoma protein) pathology is rare. In this review, these three major pathological types of FTLD are discussed.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642013DN70100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.7 n.1 2013
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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