qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642008000100009 |
Resumo: | Abstract qEEG spectral analysis has been considered highly sensitive to cortical functional changes and agrees strongly with the clinical diagnosis of AD. The sensitivity of spectral analysis has ranged from 71% to 81% in several studies.1-3. Objective: The aim of this study was to retrospectively evaluate whether alpha qEEG spectral peak can supplement clinical examination by constituting an independent tool to monitor treatment and follow-up of dementia progression in Alzheimer's disease (AD). In addition, we examined the demographic data and alpha power spectra distribution of patients and elderly normal controls. Methods: qEEGs were selected from 2 groups of patients: normal controls (n=30), and patients who fulfilled criteria for mild probable AD diagnosis (n=41). The alpha qEEG spectral analysis and MMSE were performed once or twice a year. Results: In our groups, MMSE scores and qEEG alpha spectral peak were unchanged (no statistical differences) after anticholinesterase use where qEEG spectral peak was never lower than 8 Hz in the control group. Conclusion: This study supports two important concepts. First, 8 Hz alpha appears to be the lowest awake spectral peak compatible with normality. And finally, in a clinical context, qEEG is a valuable diagnostic tool that could prove useful for Dementia follow-up. |
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Dementia & Neuropsychologia |
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qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-upquantitative electroencephalographyspectral analysisdementiaAlzheimer's diseasememory complaintcognitionqEEGAbstract qEEG spectral analysis has been considered highly sensitive to cortical functional changes and agrees strongly with the clinical diagnosis of AD. The sensitivity of spectral analysis has ranged from 71% to 81% in several studies.1-3. Objective: The aim of this study was to retrospectively evaluate whether alpha qEEG spectral peak can supplement clinical examination by constituting an independent tool to monitor treatment and follow-up of dementia progression in Alzheimer's disease (AD). In addition, we examined the demographic data and alpha power spectra distribution of patients and elderly normal controls. Methods: qEEGs were selected from 2 groups of patients: normal controls (n=30), and patients who fulfilled criteria for mild probable AD diagnosis (n=41). The alpha qEEG spectral analysis and MMSE were performed once or twice a year. Results: In our groups, MMSE scores and qEEG alpha spectral peak were unchanged (no statistical differences) after anticholinesterase use where qEEG spectral peak was never lower than 8 Hz in the control group. Conclusion: This study supports two important concepts. First, 8 Hz alpha appears to be the lowest awake spectral peak compatible with normality. And finally, in a clinical context, qEEG is a valuable diagnostic tool that could prove useful for Dementia follow-up.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2008-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642008000100009Dementia & Neuropsychologia v.2 n.1 2008reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN20100003info:eu-repo/semantics/openAccessRaicher,IrinaTakahashi,Daniel YasumasaKanda,Paulo Afonso MedeirosNitrini,RicardoAnghinah,Renatoeng2016-09-13T00:00:00Zoai:scielo:S1980-57642008000100009Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-09-13T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
title |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
spellingShingle |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up Raicher,Irina quantitative electroencephalography spectral analysis dementia Alzheimer's disease memory complaint cognition qEEG |
title_short |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
title_full |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
title_fullStr |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
title_full_unstemmed |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
title_sort |
qEEG spectral peak in Alzheimer's disease: A possible tool for treatment follow-up |
author |
Raicher,Irina |
author_facet |
Raicher,Irina Takahashi,Daniel Yasumasa Kanda,Paulo Afonso Medeiros Nitrini,Ricardo Anghinah,Renato |
author_role |
author |
author2 |
Takahashi,Daniel Yasumasa Kanda,Paulo Afonso Medeiros Nitrini,Ricardo Anghinah,Renato |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Raicher,Irina Takahashi,Daniel Yasumasa Kanda,Paulo Afonso Medeiros Nitrini,Ricardo Anghinah,Renato |
dc.subject.por.fl_str_mv |
quantitative electroencephalography spectral analysis dementia Alzheimer's disease memory complaint cognition qEEG |
topic |
quantitative electroencephalography spectral analysis dementia Alzheimer's disease memory complaint cognition qEEG |
description |
Abstract qEEG spectral analysis has been considered highly sensitive to cortical functional changes and agrees strongly with the clinical diagnosis of AD. The sensitivity of spectral analysis has ranged from 71% to 81% in several studies.1-3. Objective: The aim of this study was to retrospectively evaluate whether alpha qEEG spectral peak can supplement clinical examination by constituting an independent tool to monitor treatment and follow-up of dementia progression in Alzheimer's disease (AD). In addition, we examined the demographic data and alpha power spectra distribution of patients and elderly normal controls. Methods: qEEGs were selected from 2 groups of patients: normal controls (n=30), and patients who fulfilled criteria for mild probable AD diagnosis (n=41). The alpha qEEG spectral analysis and MMSE were performed once or twice a year. Results: In our groups, MMSE scores and qEEG alpha spectral peak were unchanged (no statistical differences) after anticholinesterase use where qEEG spectral peak was never lower than 8 Hz in the control group. Conclusion: This study supports two important concepts. First, 8 Hz alpha appears to be the lowest awake spectral peak compatible with normality. And finally, in a clinical context, qEEG is a valuable diagnostic tool that could prove useful for Dementia follow-up. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642008000100009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642008000100009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1980-57642009DN20100003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.2 n.1 2008 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
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1754212929247379456 |