Causes, effects and connectivity changes in MS-related cognitive decline

Detalhes bibliográficos
Autor(a) principal: Rimkus,Carolina de Medeiros
Data de Publicação: 2016
Outros Autores: Steenwijk,Martijn D., Barkhof,Frederik
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000100002
Resumo: Cognitive decline is a frequent but undervalued aspect of multiple sclerosis (MS). Currently, it remains unclear what the strongest determinants of cognitive dysfunction are, with grey matter damage most directly related to cognitive impairment. Multi-parametric studies seem to indicate that individual factors of MS-pathology are highly interdependent causes of grey matter atrophy and permanent brain damage. They are associated with intermediate functional effects (e.g. in functional MRI) representing a balance between disconnection and (mal) adaptive connectivity changes. Therefore, a more comprehensive MRI approach is warranted, aiming to link structural changes with functional brain organization. To better understand the disconnection syndromes and cognitive decline in MS, this paper reviews the associations between MRI metrics and cognitive performance, by discussing the interactions between multiple facets of MS pathology as determinants of brain damage and how they affect network efficiency.
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spelling Causes, effects and connectivity changes in MS-related cognitive declinemultiple sclerosiscognitionbrain mappingfunctional neuroimagingdiffusion tensor imagingCognitive decline is a frequent but undervalued aspect of multiple sclerosis (MS). Currently, it remains unclear what the strongest determinants of cognitive dysfunction are, with grey matter damage most directly related to cognitive impairment. Multi-parametric studies seem to indicate that individual factors of MS-pathology are highly interdependent causes of grey matter atrophy and permanent brain damage. They are associated with intermediate functional effects (e.g. in functional MRI) representing a balance between disconnection and (mal) adaptive connectivity changes. Therefore, a more comprehensive MRI approach is warranted, aiming to link structural changes with functional brain organization. To better understand the disconnection syndromes and cognitive decline in MS, this paper reviews the associations between MRI metrics and cognitive performance, by discussing the interactions between multiple facets of MS pathology as determinants of brain damage and how they affect network efficiency.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000100002Dementia & Neuropsychologia v.10 n.1 2016reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/s1980-57642016dn10100002info:eu-repo/semantics/openAccessRimkus,Carolina de MedeirosSteenwijk,Martijn D.Barkhof,Frederikeng2016-12-09T00:00:00Zoai:scielo:S1980-57642016000100002Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-12-09T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Causes, effects and connectivity changes in MS-related cognitive decline
title Causes, effects and connectivity changes in MS-related cognitive decline
spellingShingle Causes, effects and connectivity changes in MS-related cognitive decline
Rimkus,Carolina de Medeiros
multiple sclerosis
cognition
brain mapping
functional neuroimaging
diffusion tensor imaging
title_short Causes, effects and connectivity changes in MS-related cognitive decline
title_full Causes, effects and connectivity changes in MS-related cognitive decline
title_fullStr Causes, effects and connectivity changes in MS-related cognitive decline
title_full_unstemmed Causes, effects and connectivity changes in MS-related cognitive decline
title_sort Causes, effects and connectivity changes in MS-related cognitive decline
author Rimkus,Carolina de Medeiros
author_facet Rimkus,Carolina de Medeiros
Steenwijk,Martijn D.
Barkhof,Frederik
author_role author
author2 Steenwijk,Martijn D.
Barkhof,Frederik
author2_role author
author
dc.contributor.author.fl_str_mv Rimkus,Carolina de Medeiros
Steenwijk,Martijn D.
Barkhof,Frederik
dc.subject.por.fl_str_mv multiple sclerosis
cognition
brain mapping
functional neuroimaging
diffusion tensor imaging
topic multiple sclerosis
cognition
brain mapping
functional neuroimaging
diffusion tensor imaging
description Cognitive decline is a frequent but undervalued aspect of multiple sclerosis (MS). Currently, it remains unclear what the strongest determinants of cognitive dysfunction are, with grey matter damage most directly related to cognitive impairment. Multi-parametric studies seem to indicate that individual factors of MS-pathology are highly interdependent causes of grey matter atrophy and permanent brain damage. They are associated with intermediate functional effects (e.g. in functional MRI) representing a balance between disconnection and (mal) adaptive connectivity changes. Therefore, a more comprehensive MRI approach is warranted, aiming to link structural changes with functional brain organization. To better understand the disconnection syndromes and cognitive decline in MS, this paper reviews the associations between MRI metrics and cognitive performance, by discussing the interactions between multiple facets of MS pathology as determinants of brain damage and how they affect network efficiency.
publishDate 2016
dc.date.none.fl_str_mv 2016-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000100002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642016000100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1980-57642016dn10100002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.10 n.1 2016
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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