Morphometric brain changes during aging: Results from a Brazilian necropsy sample

Detalhes bibliográficos
Autor(a) principal: Ferretti,Renata Eloah de Lucena
Data de Publicação: 2010
Outros Autores: Jacob-Filho,Wilson, Grinberg,Lea Tenenholz, Leite,Renata Elaine Paraízo, Farfel,José Marcelo, Suemoto,Claudia Kimie, Saldiva,Paulo Hilário Nascimento, Rosemberg,Sérgio, Pasqualucci,Carlos Augusto, Nitrini,Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332
Resumo: Abstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions.
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spelling Morphometric brain changes during aging: Results from a Brazilian necropsy sampleagingbrain/anatomycephalometryAbstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332Dementia &amp; Neuropsychologia v.4 n.4 2010reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642010DN40400013info:eu-repo/semantics/openAccessFerretti,Renata Eloah de LucenaJacob-Filho,WilsonGrinberg,Lea TenenholzLeite,Renata Elaine ParaízoFarfel,José MarceloSuemoto,Claudia KimieSaldiva,Paulo Hilário NascimentoRosemberg,SérgioPasqualucci,Carlos AugustoNitrini,Ricardoeng2016-07-22T00:00:00Zoai:scielo:S1980-57642010000400332Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-22T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Morphometric brain changes during aging: Results from a Brazilian necropsy sample
title Morphometric brain changes during aging: Results from a Brazilian necropsy sample
spellingShingle Morphometric brain changes during aging: Results from a Brazilian necropsy sample
Ferretti,Renata Eloah de Lucena
aging
brain/anatomy
cephalometry
title_short Morphometric brain changes during aging: Results from a Brazilian necropsy sample
title_full Morphometric brain changes during aging: Results from a Brazilian necropsy sample
title_fullStr Morphometric brain changes during aging: Results from a Brazilian necropsy sample
title_full_unstemmed Morphometric brain changes during aging: Results from a Brazilian necropsy sample
title_sort Morphometric brain changes during aging: Results from a Brazilian necropsy sample
author Ferretti,Renata Eloah de Lucena
author_facet Ferretti,Renata Eloah de Lucena
Jacob-Filho,Wilson
Grinberg,Lea Tenenholz
Leite,Renata Elaine Paraízo
Farfel,José Marcelo
Suemoto,Claudia Kimie
Saldiva,Paulo Hilário Nascimento
Rosemberg,Sérgio
Pasqualucci,Carlos Augusto
Nitrini,Ricardo
author_role author
author2 Jacob-Filho,Wilson
Grinberg,Lea Tenenholz
Leite,Renata Elaine Paraízo
Farfel,José Marcelo
Suemoto,Claudia Kimie
Saldiva,Paulo Hilário Nascimento
Rosemberg,Sérgio
Pasqualucci,Carlos Augusto
Nitrini,Ricardo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferretti,Renata Eloah de Lucena
Jacob-Filho,Wilson
Grinberg,Lea Tenenholz
Leite,Renata Elaine Paraízo
Farfel,José Marcelo
Suemoto,Claudia Kimie
Saldiva,Paulo Hilário Nascimento
Rosemberg,Sérgio
Pasqualucci,Carlos Augusto
Nitrini,Ricardo
dc.subject.por.fl_str_mv aging
brain/anatomy
cephalometry
topic aging
brain/anatomy
cephalometry
description Abstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642010DN40400013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia &amp; Neuropsychologia v.4 n.4 2010
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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