Morphometric brain changes during aging: Results from a Brazilian necropsy sample
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332 |
Resumo: | Abstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions. |
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Dementia & Neuropsychologia |
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Morphometric brain changes during aging: Results from a Brazilian necropsy sampleagingbrain/anatomycephalometryAbstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332Dementia & Neuropsychologia v.4 n.4 2010reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642010DN40400013info:eu-repo/semantics/openAccessFerretti,Renata Eloah de LucenaJacob-Filho,WilsonGrinberg,Lea TenenholzLeite,Renata Elaine ParaízoFarfel,José MarceloSuemoto,Claudia KimieSaldiva,Paulo Hilário NascimentoRosemberg,SérgioPasqualucci,Carlos AugustoNitrini,Ricardoeng2016-07-22T00:00:00Zoai:scielo:S1980-57642010000400332Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-22T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
title |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
spellingShingle |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample Ferretti,Renata Eloah de Lucena aging brain/anatomy cephalometry |
title_short |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
title_full |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
title_fullStr |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
title_full_unstemmed |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
title_sort |
Morphometric brain changes during aging: Results from a Brazilian necropsy sample |
author |
Ferretti,Renata Eloah de Lucena |
author_facet |
Ferretti,Renata Eloah de Lucena Jacob-Filho,Wilson Grinberg,Lea Tenenholz Leite,Renata Elaine Paraízo Farfel,José Marcelo Suemoto,Claudia Kimie Saldiva,Paulo Hilário Nascimento Rosemberg,Sérgio Pasqualucci,Carlos Augusto Nitrini,Ricardo |
author_role |
author |
author2 |
Jacob-Filho,Wilson Grinberg,Lea Tenenholz Leite,Renata Elaine Paraízo Farfel,José Marcelo Suemoto,Claudia Kimie Saldiva,Paulo Hilário Nascimento Rosemberg,Sérgio Pasqualucci,Carlos Augusto Nitrini,Ricardo |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferretti,Renata Eloah de Lucena Jacob-Filho,Wilson Grinberg,Lea Tenenholz Leite,Renata Elaine Paraízo Farfel,José Marcelo Suemoto,Claudia Kimie Saldiva,Paulo Hilário Nascimento Rosemberg,Sérgio Pasqualucci,Carlos Augusto Nitrini,Ricardo |
dc.subject.por.fl_str_mv |
aging brain/anatomy cephalometry |
topic |
aging brain/anatomy cephalometry |
description |
Abstract The present study aimed to establish the morphometric brain changes during aging in a necropsy series from Brazil and determine whether sexual dimorphisms interfere in these changes. Methods: A cross-sectional study was conducted at the São Paulo Autopsy Service in Brazil where, after informed consent, data was gathered from next of kin interview with reference to clinical status prior to death. Brain weight, volume and density measurements were taken and then adjusted for head circumference. Descriptive statistics and tests of hypothesis and correlations were applied, considering a p-value of 0.05. Results: 414 subjects, mostly men (60.4%), with a mean age of 67.1 years, were included. The mean brain weight of the sample was 1219.2g±140.9 and mean volume was 1217mL±152.3. The mean brain density of the sample was 1.0g/mL±0.09. Values differed between males and females in terms of weight and volume. Brain weight decreased during aging by about 45g per decade (r= -0.300; p<0.01) and volume by about 43mL (r= -0.278; p<0.00). Mean density of the sample was 1.0 g/mL in both genders. Conclusions: Brain weight and volume (with or without corrections) decreased during aging, and these reductions were more pronounced in women. Density remained unchanged for both genders. Further studies are needed to investigate factors associated to these reductions. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000400332 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1980-57642010DN40400013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.4 n.4 2010 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
_version_ |
1754212930143911936 |