Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study

Detalhes bibliográficos
Autor(a) principal: Souza,Leonardo Cruz de
Data de Publicação: 2019
Outros Autores: Mariano,Luciano Inácio, Moraes,Renata Freire de, Caramelli,Paulo
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356
Resumo: ABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments.
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spelling Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case studyAlzheimer's diseasefrontotemporal dementiaatypical Alzheimer's diseasebiomarkersABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2019-09-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356Dementia & Neuropsychologia v.13 n.3 2019reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/1980-57642018dn13-030015info:eu-repo/semantics/openAccessSouza,Leonardo Cruz deMariano,Luciano InácioMoraes,Renata Freire deCaramelli,Pauloeng2019-09-20T00:00:00Zoai:scielo:S1980-57642019000300356Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2019-09-20T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
title Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
spellingShingle Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
Souza,Leonardo Cruz de
Alzheimer's disease
frontotemporal dementia
atypical Alzheimer's disease
biomarkers
title_short Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
title_full Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
title_fullStr Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
title_full_unstemmed Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
title_sort Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study
author Souza,Leonardo Cruz de
author_facet Souza,Leonardo Cruz de
Mariano,Luciano Inácio
Moraes,Renata Freire de
Caramelli,Paulo
author_role author
author2 Mariano,Luciano Inácio
Moraes,Renata Freire de
Caramelli,Paulo
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza,Leonardo Cruz de
Mariano,Luciano Inácio
Moraes,Renata Freire de
Caramelli,Paulo
dc.subject.por.fl_str_mv Alzheimer's disease
frontotemporal dementia
atypical Alzheimer's disease
biomarkers
topic Alzheimer's disease
frontotemporal dementia
atypical Alzheimer's disease
biomarkers
description ABSTRACT Alzheimer's disease (AD) has heterogeneous clinical presentations. Amnestic progressive disorder leading to dementia is the most typical, but non-amnestic presentations are also recognized. Here we report a case of frontal variant of AD. A right-handed woman, aged 68 years, was referred for progressive behavioral disorders and personality changes. She had a corroborated history of dietary changes, hyperorality, impulsivity, affective indifference and apathy, with functional impairment. Cognitive assessment yielded severe executive deficits. Positron emission tomography with fluorodeoxyglucose showed marked hypometabolism in frontotemporal regions, with relative preservation of parietal regions. CSF AD biomarkers showed low Aβ42, high Tau and high P-Tau. The patient fulfilled criteria for probable behavioral variant frontotemporal dementia. However, considering the AD pathophysiological signature on CSF biomarkers, a diagnosis of frontal variant of AD was established. In the perspective of disease-modifying therapies, it is important to identify atypical Alzheimer presentations, as these patients may be candidates for specific treatments.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300356
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1980-57642018dn13-030015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.13 n.3 2019
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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