Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Detalhes bibliográficos
Autor(a) principal: Paiva,Fernando Fernandes
Data de Publicação: 2013
Outros Autores: Otaduy,Maria Concepcion Garcia, Oliveira-Souza,Ricardo de, Moll,Jorge, Bramati,Ivanei Edson, Oliveira,Luciane, Souza,Andrea Silveira de, Tovar-Moll,Fernanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216
Resumo: ABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS.
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spelling Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0Tbrainmagnetic resonance spectroscopy1.5T3.0TABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216Dementia & Neuropsychologia v.7 n.2 2013reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642013DN70200013info:eu-repo/semantics/openAccessPaiva,Fernando FernandesOtaduy,Maria Concepcion GarciaOliveira-Souza,Ricardo deMoll,JorgeBramati,Ivanei EdsonOliveira,LucianeSouza,Andrea Silveira deTovar-Moll,Fernandaeng2016-06-09T00:00:00Zoai:scielo:S1980-57642013000200216Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-06-09T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
title Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
spellingShingle Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
Paiva,Fernando Fernandes
brain
magnetic resonance spectroscopy
1.5T
3.0T
title_short Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
title_full Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
title_fullStr Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
title_full_unstemmed Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
title_sort Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
author Paiva,Fernando Fernandes
author_facet Paiva,Fernando Fernandes
Otaduy,Maria Concepcion Garcia
Oliveira-Souza,Ricardo de
Moll,Jorge
Bramati,Ivanei Edson
Oliveira,Luciane
Souza,Andrea Silveira de
Tovar-Moll,Fernanda
author_role author
author2 Otaduy,Maria Concepcion Garcia
Oliveira-Souza,Ricardo de
Moll,Jorge
Bramati,Ivanei Edson
Oliveira,Luciane
Souza,Andrea Silveira de
Tovar-Moll,Fernanda
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paiva,Fernando Fernandes
Otaduy,Maria Concepcion Garcia
Oliveira-Souza,Ricardo de
Moll,Jorge
Bramati,Ivanei Edson
Oliveira,Luciane
Souza,Andrea Silveira de
Tovar-Moll,Fernanda
dc.subject.por.fl_str_mv brain
magnetic resonance spectroscopy
1.5T
3.0T
topic brain
magnetic resonance spectroscopy
1.5T
3.0T
description ABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642013DN70200013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.7 n.2 2013
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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