Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216 |
Resumo: | ABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS. |
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Dementia & Neuropsychologia |
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Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0Tbrainmagnetic resonance spectroscopy1.5T3.0TABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216Dementia & Neuropsychologia v.7 n.2 2013reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642013DN70200013info:eu-repo/semantics/openAccessPaiva,Fernando FernandesOtaduy,Maria Concepcion GarciaOliveira-Souza,Ricardo deMoll,JorgeBramati,Ivanei EdsonOliveira,LucianeSouza,Andrea Silveira deTovar-Moll,Fernandaeng2016-06-09T00:00:00Zoai:scielo:S1980-57642013000200216Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-06-09T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
title |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
spellingShingle |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T Paiva,Fernando Fernandes brain magnetic resonance spectroscopy 1.5T 3.0T |
title_short |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
title_full |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
title_fullStr |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
title_full_unstemmed |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
title_sort |
Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T |
author |
Paiva,Fernando Fernandes |
author_facet |
Paiva,Fernando Fernandes Otaduy,Maria Concepcion Garcia Oliveira-Souza,Ricardo de Moll,Jorge Bramati,Ivanei Edson Oliveira,Luciane Souza,Andrea Silveira de Tovar-Moll,Fernanda |
author_role |
author |
author2 |
Otaduy,Maria Concepcion Garcia Oliveira-Souza,Ricardo de Moll,Jorge Bramati,Ivanei Edson Oliveira,Luciane Souza,Andrea Silveira de Tovar-Moll,Fernanda |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Paiva,Fernando Fernandes Otaduy,Maria Concepcion Garcia Oliveira-Souza,Ricardo de Moll,Jorge Bramati,Ivanei Edson Oliveira,Luciane Souza,Andrea Silveira de Tovar-Moll,Fernanda |
dc.subject.por.fl_str_mv |
brain magnetic resonance spectroscopy 1.5T 3.0T |
topic |
brain magnetic resonance spectroscopy 1.5T 3.0T |
description |
ABSTRACT Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength. Objective: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting. Methods: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order. Results: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations. Conclusions: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000200216 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1980-57642013DN70200013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.7 n.2 2013 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
_version_ |
1754212930621014016 |