Parkinson’s disease and dopamine transporter neuroimaging: a critical review

Detalhes bibliográficos
Autor(a) principal: Shih,Ming Chi
Data de Publicação: 2006
Outros Autores: Hoexter,Marcelo Queiroz, Andrade,Luiz Augusto Franco de, Bressan,Rodrigo Affonseca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000300014
Resumo: Parkinson’s disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson’s disease diagnosis (sensitivity and specificity).
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spelling Parkinson’s disease and dopamine transporter neuroimaging: a critical reviewParkinson diseaseDopamineEmission-computed tomographySingle-photon emission-computerized tomographyDiagnosisParkinson’s disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson’s disease diagnosis (sensitivity and specificity).Associação Paulista de Medicina - APM2006-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000300014Sao Paulo Medical Journal v.124 n.3 2006reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802006000300014info:eu-repo/semantics/openAccessShih,Ming ChiHoexter,Marcelo QueirozAndrade,Luiz Augusto Franco deBressan,Rodrigo Affonsecaeng2006-09-13T00:00:00Zoai:scielo:S1516-31802006000300014Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2006-09-13T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Parkinson’s disease and dopamine transporter neuroimaging: a critical review
title Parkinson’s disease and dopamine transporter neuroimaging: a critical review
spellingShingle Parkinson’s disease and dopamine transporter neuroimaging: a critical review
Shih,Ming Chi
Parkinson disease
Dopamine
Emission-computed tomography
Single-photon emission-computerized tomography
Diagnosis
title_short Parkinson’s disease and dopamine transporter neuroimaging: a critical review
title_full Parkinson’s disease and dopamine transporter neuroimaging: a critical review
title_fullStr Parkinson’s disease and dopamine transporter neuroimaging: a critical review
title_full_unstemmed Parkinson’s disease and dopamine transporter neuroimaging: a critical review
title_sort Parkinson’s disease and dopamine transporter neuroimaging: a critical review
author Shih,Ming Chi
author_facet Shih,Ming Chi
Hoexter,Marcelo Queiroz
Andrade,Luiz Augusto Franco de
Bressan,Rodrigo Affonseca
author_role author
author2 Hoexter,Marcelo Queiroz
Andrade,Luiz Augusto Franco de
Bressan,Rodrigo Affonseca
author2_role author
author
author
dc.contributor.author.fl_str_mv Shih,Ming Chi
Hoexter,Marcelo Queiroz
Andrade,Luiz Augusto Franco de
Bressan,Rodrigo Affonseca
dc.subject.por.fl_str_mv Parkinson disease
Dopamine
Emission-computed tomography
Single-photon emission-computerized tomography
Diagnosis
topic Parkinson disease
Dopamine
Emission-computed tomography
Single-photon emission-computerized tomography
Diagnosis
description Parkinson’s disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson’s disease diagnosis (sensitivity and specificity).
publishDate 2006
dc.date.none.fl_str_mv 2006-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000300014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000300014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802006000300014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.124 n.3 2006
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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