Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Detalhes bibliográficos
Autor(a) principal: Barbosa,Fabiano Timbó
Data de Publicação: 2009
Outros Autores: Jucá,Mário Jorge, Castro,Aldemar Araujo, Duarte,José Lira, Barbosa,Luciano Timbó
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000200008
Resumo: Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.
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spelling Artificial oxygen carriers as a possible alternative to red cells in clinical practiceHemoglobinsAnemiaBloodBlood transfusionBlood substitutesFluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.Associação Paulista de Medicina - APM2009-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000200008Sao Paulo Medical Journal v.127 n.2 2009reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802009000200008info:eu-repo/semantics/openAccessBarbosa,Fabiano TimbóJucá,Mário JorgeCastro,Aldemar AraujoDuarte,José LiraBarbosa,Luciano Timbóeng2009-07-06T00:00:00Zoai:scielo:S1516-31802009000200008Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-07-06T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Artificial oxygen carriers as a possible alternative to red cells in clinical practice
title Artificial oxygen carriers as a possible alternative to red cells in clinical practice
spellingShingle Artificial oxygen carriers as a possible alternative to red cells in clinical practice
Barbosa,Fabiano Timbó
Hemoglobins
Anemia
Blood
Blood transfusion
Blood substitutes
title_short Artificial oxygen carriers as a possible alternative to red cells in clinical practice
title_full Artificial oxygen carriers as a possible alternative to red cells in clinical practice
title_fullStr Artificial oxygen carriers as a possible alternative to red cells in clinical practice
title_full_unstemmed Artificial oxygen carriers as a possible alternative to red cells in clinical practice
title_sort Artificial oxygen carriers as a possible alternative to red cells in clinical practice
author Barbosa,Fabiano Timbó
author_facet Barbosa,Fabiano Timbó
Jucá,Mário Jorge
Castro,Aldemar Araujo
Duarte,José Lira
Barbosa,Luciano Timbó
author_role author
author2 Jucá,Mário Jorge
Castro,Aldemar Araujo
Duarte,José Lira
Barbosa,Luciano Timbó
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Barbosa,Fabiano Timbó
Jucá,Mário Jorge
Castro,Aldemar Araujo
Duarte,José Lira
Barbosa,Luciano Timbó
dc.subject.por.fl_str_mv Hemoglobins
Anemia
Blood
Blood transfusion
Blood substitutes
topic Hemoglobins
Anemia
Blood
Blood transfusion
Blood substitutes
description Fluid resuscitation is intended to eliminate microcirculatory disorders and restore adequate tissue oxygenation. The safety limits for a restrictive transfusion policy are given by patients' individual tolerance of acute normovolemic anemia. Artificial oxygen carriers based on perfluorocarbon or hemoglobin are attractive alternatives to allogenic red blood cells. There are many risks involved in allogenic blood transfusions and they include transmission of infections, delayed postoperative wound healing, transfusion reactions, immunomodulation and cancer recurrence. Regardless of whether artificial oxygen carriers are available for routine clinical use, further studies are needed in order to show the safety and efficacy of these substances for clinical practice.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802009000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.127 n.2 2009
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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