Primary malignancy in giant cell tumor: a case report

• Autor(a) principal: Bispo Júnior,Rosalvo Zósimo
• Data de Publicação: 2009
• Outros Autores: Camargo,Olavo Pires de, Ida,Cristiane Marie, Baptista,André Mathias, Ribeiro,Marcelo Barbosa, Bruno,José Marcello, Oliveira,Cláudia Regina Gomes Cardim Mendes de
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: São Paulo medical journal (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802009000500011
• topic: Bone neoplasms; Bone tissue; Giant cell tumor of bone; Osteosarcoma; Histiocytoma, malignant fibrous

CONTEXT: Primary malignancy in giant cell tumor (PMGCT) is rare. It is defined as a high-grade sarcoma originating in a giant cell tumor (GCT) and seems to behave less aggressively than its secondary counterpart does. CASE REPORT: This report presents the case of a 39-year-old female with pain in her left shoulder for one month. Radiography showed a pathological fracture of the proximal humerus associated with an osteolytic lesion. Histopathological analysis showed typical areas of GCT juxtaposed with a sarcomatous component. CONCLUSIONS: PMGCT seems to behave less aggressively than secondary malignancy in GCT, and it may simulate its more common benign counterpart clinically and radiographically. However, it requires a more aggressive type of treatment.