No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200073 |
Resumo: | CONTEXT AND OBJECTIVE:Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes.DESIGN AND SETTING:Cross-sectional study at a tertiary hospital.METHODS:Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m2; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic).RESULTS:There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m2). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl).CONCLUSION:There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed. |
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No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional studyVitamin DGlucose intolerancePrediabetic stateHyperglycemiaDiabetes mellitusCONTEXT AND OBJECTIVE:Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes.DESIGN AND SETTING:Cross-sectional study at a tertiary hospital.METHODS:Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m2; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic).RESULTS:There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m2). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl).CONCLUSION:There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed.Associação Paulista de Medicina - APM2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200073Sao Paulo Medical Journal v.133 n.2 2015reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2013.7180005info:eu-repo/semantics/openAccessGiorelli,Guilherme de VieiraMatos,Lívia Nascimento deSaado,AmirSoibelman,Vera LúciaDias,Cristiane Bitencourteng2015-10-09T00:00:00Zoai:scielo:S1516-31802015000200073Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2015-10-09T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
title |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
spellingShingle |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study Giorelli,Guilherme de Vieira Vitamin D Glucose intolerance Prediabetic state Hyperglycemia Diabetes mellitus |
title_short |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
title_full |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
title_fullStr |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
title_full_unstemmed |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
title_sort |
No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross-sectional study |
author |
Giorelli,Guilherme de Vieira |
author_facet |
Giorelli,Guilherme de Vieira Matos,Lívia Nascimento de Saado,Amir Soibelman,Vera Lúcia Dias,Cristiane Bitencourt |
author_role |
author |
author2 |
Matos,Lívia Nascimento de Saado,Amir Soibelman,Vera Lúcia Dias,Cristiane Bitencourt |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Giorelli,Guilherme de Vieira Matos,Lívia Nascimento de Saado,Amir Soibelman,Vera Lúcia Dias,Cristiane Bitencourt |
dc.subject.por.fl_str_mv |
Vitamin D Glucose intolerance Prediabetic state Hyperglycemia Diabetes mellitus |
topic |
Vitamin D Glucose intolerance Prediabetic state Hyperglycemia Diabetes mellitus |
description |
CONTEXT AND OBJECTIVE:Several studies have evaluated the role of low 25-hydroxyvitamin D (25OHD3) in the pathogenesis of type 2 diabetes (T2DM) and have presented controversial results. The metabolic processes that culminate in T2DM begin under prediabetic conditions. Our aim was to analyze the association between 25OHD3 and glucose metabolism in individuals who were free from but at elevated risk of diabetes.DESIGN AND SETTING:Cross-sectional study at a tertiary hospital.METHODS:Anthropometric and laboratory profiles were determined in patients with one or more of the following risk factors: hypertension; body mass index (BMI) ≥ 25 kg/m2; waist circumference > 80 cm for women and > 94 cm for men; first-degree relatives with diabetes; women with large-for-gestational-age newborns or with gestational T2DM; HDL-cholesterol (high density lipoprotein) < 35 mg/dl; and triglycerides > 250 mg/dl. The patients were divided into two groups: one with prediabetes (abnormal fasting plasma glucose or oral glucose tolerance test) and the other with normal glucose (euglycemic).RESULTS:There was no statistically significant difference between the prediabetic group (n = 38) and euglycemic group (n = 15) regarding age (66.4 ± 10.6 versus 62.6 ± 9.1 years), gender (52.6 versus 73.3% female) and BMI (30.1 ± 4.61 versus 27.9 ± 4.7 kg/m2). Low serum levels of 25OHD3 were found in both groups, without any statistically significant difference between them (29.1 ± 11.8 versus 26.87 ± 9.2 ng/dl).CONCLUSION:There was no association between 25OHD3 levels and the clinical or laboratorial variables analyzed. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200073 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2013.7180005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.133 n.2 2015 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209264337944576 |