Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Detalhes bibliográficos
Autor(a) principal: Figueiredo, Maria Stella
Data de Publicação: 2004
Outros Autores: Vicari, Perla, Kimura, Eliza Yuriko Sugano, Antunes, Sandra Vallin, Yamamoto, Mihoko
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: https://periodicosapm.emnuvens.com.br/spmj/article/view/2554
Resumo: CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
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spelling Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemiaHemoglobinopatia H adquirida em um paciente com anemia aplástica e evolução para leucemia mielóide agudaDoençaHemoglobina HAnemia aplásticaLeucemia mielóideSíndromes mielodisplásicasHemoglobin HDiseaseAplastic anemiaMyeloid leukemiaMyelodysplastic syndromesCONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.CONTEXTO: O prognóstico da anemia aplástica grave melhorou com o advento do transplante de medula óssea e do tratamento imunossupressor com globulina antitimocitária. Em contraste com o sucesso destes protocolos, os estudos com seguimento a longo prazo mostraram a ocorrência de doenças clonais, tais como: hemoglobinúria paroxística noturna, síndrome mielodisplásica e leucemia aguda. RELATO DE CASO: Nós relatamos o primeiro caso descrito no Brasil de um paciente com anemia aplástica que evoluiu para síndrome mielodisplásica e leucemia mielóide aguda associada a presença de hemoglobina H e aumento da hemoglobina fetal.São Paulo Medical JournalSão Paulo Medical Journal2004-11-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/2554São Paulo Medical Journal; Vol. 122 No. 6 (2004); 273-275São Paulo Medical Journal; v. 122 n. 6 (2004); 273-2751806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/2554/2439https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFigueiredo, Maria StellaVicari, PerlaKimura, Eliza Yuriko SuganoAntunes, Sandra VallinYamamoto, Mihoko2023-10-05T18:23:35Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2554Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-10-05T18:23:35São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
Hemoglobinopatia H adquirida em um paciente com anemia aplástica e evolução para leucemia mielóide aguda
title Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
spellingShingle Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
Figueiredo, Maria Stella
Doença
Hemoglobina H
Anemia aplástica
Leucemia mielóide
Síndromes mielodisplásicas
Hemoglobin H
Disease
Aplastic anemia
Myeloid leukemia
Myelodysplastic syndromes
title_short Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
title_full Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
title_fullStr Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
title_full_unstemmed Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
title_sort Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
author Figueiredo, Maria Stella
author_facet Figueiredo, Maria Stella
Vicari, Perla
Kimura, Eliza Yuriko Sugano
Antunes, Sandra Vallin
Yamamoto, Mihoko
author_role author
author2 Vicari, Perla
Kimura, Eliza Yuriko Sugano
Antunes, Sandra Vallin
Yamamoto, Mihoko
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Figueiredo, Maria Stella
Vicari, Perla
Kimura, Eliza Yuriko Sugano
Antunes, Sandra Vallin
Yamamoto, Mihoko
dc.subject.por.fl_str_mv Doença
Hemoglobina H
Anemia aplástica
Leucemia mielóide
Síndromes mielodisplásicas
Hemoglobin H
Disease
Aplastic anemia
Myeloid leukemia
Myelodysplastic syndromes
topic Doença
Hemoglobina H
Anemia aplástica
Leucemia mielóide
Síndromes mielodisplásicas
Hemoglobin H
Disease
Aplastic anemia
Myeloid leukemia
Myelodysplastic syndromes
description CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
publishDate 2004
dc.date.none.fl_str_mv 2004-11-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2554
url https://periodicosapm.emnuvens.com.br/spmj/article/view/2554
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2554/2439
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 122 No. 6 (2004); 273-275
São Paulo Medical Journal; v. 122 n. 6 (2004); 273-275
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1825135076594155520

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