LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA

Detalhes bibliográficos
Autor(a) principal: Marinho, Flávia Estrela Maroja
Data de Publicação: 2014
Outros Autores: Nishimori, Fátima Satomi, Silva, Pedro Etienne Arreguy Rodrigues, Avelleira, João Carlos Regazzi, Vasconcelos, Laura Cardoso, Filgueiras, Rose Lady Dutra
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.71.2.180
Resumo: Cutaneous involvement by myeloid leukemic cells is an unusual phenomenon. The authors analyze the case of a 55-year-old male patient with myelodysplastic syndrome who presented erythematous papules on the face, trunk, arms and legs. Skin biopsy showed a dermal infiltration caused by blast myeloid cells. Immunohistochemical analysis was positive for myeloperoxidase, confirming leukemia cutis. Acute myeloid leukemia was diagnosed and the patient was treated with chemotherapy and then with rescue chemotherapy but without response. The haematologic disease progressed and the patient died after four months. The diagnosis of leukemia cutis in patients with myelodysplastic syndrome is indicative of concomitant or impending acute leukemic transformation. Early recognition is essential with important therapeutic and prognostic implications.
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spelling LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIALEUCEMIA CÚTIS COMO SINAL DA EVOLUÇÃO DA SÍNDROME MIELODISPLÁSICA PARA LEUCEMIA MIELOIDE AGUDAMyelodysplastic syndromesPreleukemiaLeukemiamyeloidacuteSkin neoplasmsSíndrome mielodisplásicosMielodisplasiaLeucemia mieloide agudaNeoplasias da peleCutaneous involvement by myeloid leukemic cells is an unusual phenomenon. The authors analyze the case of a 55-year-old male patient with myelodysplastic syndrome who presented erythematous papules on the face, trunk, arms and legs. Skin biopsy showed a dermal infiltration caused by blast myeloid cells. Immunohistochemical analysis was positive for myeloperoxidase, confirming leukemia cutis. Acute myeloid leukemia was diagnosed and the patient was treated with chemotherapy and then with rescue chemotherapy but without response. The haematologic disease progressed and the patient died after four months. The diagnosis of leukemia cutis in patients with myelodysplastic syndrome is indicative of concomitant or impending acute leukemic transformation. Early recognition is essential with important therapeutic and prognostic implications.O envolvimento cutâneo por células leucêmicas mielóides é fenômeno raro. Os autores relatam caso de paciente, masculino, 55 anos, com síndrome mielodisplásica com lesões papulares eritemato-purpúricas na face, tronco e membros superiores e inferiores. Foi realizada biópsia de lesão que evidenciou infiltrado dérmico por blastos mielóides e imunoistoquímica positiva para mieloperoxidase, confirmando leucemia cútis. O paciente evoluiu para leucemia mieloide aguda, sendo submetido à quimioterapia inicial e depois a esquema quimioterápico de resgate, porém não obteve resposta, havendo piora do quadro hematológico e falecendo após 4 meses. O diagnóstico de leucemia cútis em paciente com síndrome mielodisplásica indica a concomitância ou iminente transformação para leucemia mieloide aguda. Seu reconhecimento precoce é importante, em vista de sua implicação terapêutica e prognóstica.Sociedade Portuguesa de Dermatologia e Venereologia2014-06-24T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.71.2.180oai:ojs.revista.spdv.com.pt:article/180Journal of the Portuguese Society of Dermatology and Venereology; Vol 71 No 2 (2013): Abril-Junho; 249-252Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 71 n. 2 (2013): Abril-Junho; 249-2522182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/180https://doi.org/10.29021/spdv.71.2.180https://revista.spdv.com.pt/index.php/spdv/article/view/180/164Marinho, Flávia Estrela MarojaNishimori, Fátima SatomiSilva, Pedro Etienne Arreguy RodriguesAvelleira, João Carlos RegazziVasconcelos, Laura CardosoFilgueiras, Rose Lady Dutrainfo:eu-repo/semantics/openAccess2022-10-06T12:34:43Zoai:ojs.revista.spdv.com.pt:article/180Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:10:44.077298Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
LEUCEMIA CÚTIS COMO SINAL DA EVOLUÇÃO DA SÍNDROME MIELODISPLÁSICA PARA LEUCEMIA MIELOIDE AGUDA
title LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
spellingShingle LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
Marinho, Flávia Estrela Maroja
Myelodysplastic syndromes
Preleukemia
Leukemia
myeloid
acute
Skin neoplasms
Síndrome mielodisplásicos
Mielodisplasia
Leucemia mieloide aguda
Neoplasias da pele
title_short LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
title_full LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
title_fullStr LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
title_full_unstemmed LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
title_sort LEUKEMIA CUTIS AS A SIGN OF PROGRESSION OF MYELODYSPLASTIC SYNDROME TO ACUTE MYELOID LEUKEMIA
author Marinho, Flávia Estrela Maroja
author_facet Marinho, Flávia Estrela Maroja
Nishimori, Fátima Satomi
Silva, Pedro Etienne Arreguy Rodrigues
Avelleira, João Carlos Regazzi
Vasconcelos, Laura Cardoso
Filgueiras, Rose Lady Dutra
author_role author
author2 Nishimori, Fátima Satomi
Silva, Pedro Etienne Arreguy Rodrigues
Avelleira, João Carlos Regazzi
Vasconcelos, Laura Cardoso
Filgueiras, Rose Lady Dutra
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marinho, Flávia Estrela Maroja
Nishimori, Fátima Satomi
Silva, Pedro Etienne Arreguy Rodrigues
Avelleira, João Carlos Regazzi
Vasconcelos, Laura Cardoso
Filgueiras, Rose Lady Dutra
dc.subject.por.fl_str_mv Myelodysplastic syndromes
Preleukemia
Leukemia
myeloid
acute
Skin neoplasms
Síndrome mielodisplásicos
Mielodisplasia
Leucemia mieloide aguda
Neoplasias da pele
topic Myelodysplastic syndromes
Preleukemia
Leukemia
myeloid
acute
Skin neoplasms
Síndrome mielodisplásicos
Mielodisplasia
Leucemia mieloide aguda
Neoplasias da pele
description Cutaneous involvement by myeloid leukemic cells is an unusual phenomenon. The authors analyze the case of a 55-year-old male patient with myelodysplastic syndrome who presented erythematous papules on the face, trunk, arms and legs. Skin biopsy showed a dermal infiltration caused by blast myeloid cells. Immunohistochemical analysis was positive for myeloperoxidase, confirming leukemia cutis. Acute myeloid leukemia was diagnosed and the patient was treated with chemotherapy and then with rescue chemotherapy but without response. The haematologic disease progressed and the patient died after four months. The diagnosis of leukemia cutis in patients with myelodysplastic syndrome is indicative of concomitant or impending acute leukemic transformation. Early recognition is essential with important therapeutic and prognostic implications.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-24T00:00:00Z
dc.type.driver.fl_str_mv journal article
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.71.2.180
oai:ojs.revista.spdv.com.pt:article/180
url https://doi.org/10.29021/spdv.71.2.180
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/180
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/180
https://doi.org/10.29021/spdv.71.2.180
https://revista.spdv.com.pt/index.php/spdv/article/view/180/164
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 71 No 2 (2013): Abril-Junho; 249-252
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 71 n. 2 (2013): Abril-Junho; 249-252
2182-2409
2182-2395
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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