Functional alterations of the autonomic nervous system in Chagas' heart disease

Detalhes bibliográficos
Autor(a) principal: Amorim,Dalmo de Souza
Data de Publicação: 1995
Outros Autores: Marin Neto,José Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200007
Resumo: Several independent pathological studies in experimental models and in human beings showed conspicuous autonomic denervation in Chagas' disease. In spite of the inherently complex structural organization of the autonomic nervous system, the parasympathetic and sympathetic divisions are involved, as shown by many functional studies. Hence, Chagas' disease represents a unique model of impairment of the autonomic control of the heart, in absence of the nonspecific effects of cardiac failure. An important limitation of the studies thus far carried out is the lack of a better knowledge of the molecular biology characteristics of different strains of T. cruzi. This could explain some geographical discrepancies found in the clinical behaviour of Chagas' disease, and contribute to a better understanding of its pathophysiology.
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spelling Functional alterations of the autonomic nervous system in Chagas' heart diseaseChagas' diseaseAutonomic nervous systemSeveral independent pathological studies in experimental models and in human beings showed conspicuous autonomic denervation in Chagas' disease. In spite of the inherently complex structural organization of the autonomic nervous system, the parasympathetic and sympathetic divisions are involved, as shown by many functional studies. Hence, Chagas' disease represents a unique model of impairment of the autonomic control of the heart, in absence of the nonspecific effects of cardiac failure. An important limitation of the studies thus far carried out is the lack of a better knowledge of the molecular biology characteristics of different strains of T. cruzi. This could explain some geographical discrepancies found in the clinical behaviour of Chagas' disease, and contribute to a better understanding of its pathophysiology.Associação Paulista de Medicina - APM1995-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200007Sao Paulo Medical Journal v.113 n.2 1995reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801995000200007info:eu-repo/semantics/openAccessAmorim,Dalmo de SouzaMarin Neto,José Antonioeng2009-05-28T00:00:00Zoai:scielo:S1516-31801995000200007Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-05-28T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Functional alterations of the autonomic nervous system in Chagas' heart disease
title Functional alterations of the autonomic nervous system in Chagas' heart disease
spellingShingle Functional alterations of the autonomic nervous system in Chagas' heart disease
Amorim,Dalmo de Souza
Chagas' disease
Autonomic nervous system
title_short Functional alterations of the autonomic nervous system in Chagas' heart disease
title_full Functional alterations of the autonomic nervous system in Chagas' heart disease
title_fullStr Functional alterations of the autonomic nervous system in Chagas' heart disease
title_full_unstemmed Functional alterations of the autonomic nervous system in Chagas' heart disease
title_sort Functional alterations of the autonomic nervous system in Chagas' heart disease
author Amorim,Dalmo de Souza
author_facet Amorim,Dalmo de Souza
Marin Neto,José Antonio
author_role author
author2 Marin Neto,José Antonio
author2_role author
dc.contributor.author.fl_str_mv Amorim,Dalmo de Souza
Marin Neto,José Antonio
dc.subject.por.fl_str_mv Chagas' disease
Autonomic nervous system
topic Chagas' disease
Autonomic nervous system
description Several independent pathological studies in experimental models and in human beings showed conspicuous autonomic denervation in Chagas' disease. In spite of the inherently complex structural organization of the autonomic nervous system, the parasympathetic and sympathetic divisions are involved, as shown by many functional studies. Hence, Chagas' disease represents a unique model of impairment of the autonomic control of the heart, in absence of the nonspecific effects of cardiac failure. An important limitation of the studies thus far carried out is the lack of a better knowledge of the molecular biology characteristics of different strains of T. cruzi. This could explain some geographical discrepancies found in the clinical behaviour of Chagas' disease, and contribute to a better understanding of its pathophysiology.
publishDate 1995
dc.date.none.fl_str_mv 1995-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31801995000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.113 n.2 1995
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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