Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000500290 |
Resumo: | CONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients.DESIGN AND SETTING: Experimental single cohort study conducted in the outpatient clinic of a university hospital.METHODS: Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol.RESULTS: 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment.CONCLUSIONS: Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP. |
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Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort studyAdrenergic beta-antagonistsVasodilator agentsArterial pressurePulse wave analysisHypertensionCONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients.DESIGN AND SETTING: Experimental single cohort study conducted in the outpatient clinic of a university hospital.METHODS: Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol.RESULTS: 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment.CONCLUSIONS: Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP.Associação Paulista de Medicina - APM2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000500290Sao Paulo Medical Journal v.132 n.5 2014reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2014.1325704info:eu-repo/semantics/openAccessVaz-de-Melo,Renan OliveiraGiollo-Júnior,Luiz TadeuMartinelli,Débora DadaMoreno-Júnior,HeitorMota-Gomes,Marco AntônioCipullo,José PauloYugar-Toledo,Juan CarlosVilela-Martin,José Fernandoeng2015-09-29T00:00:00Zoai:scielo:S1516-31802014000500290Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2015-09-29T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
title |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
spellingShingle |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study Vaz-de-Melo,Renan Oliveira Adrenergic beta-antagonists Vasodilator agents Arterial pressure Pulse wave analysis Hypertension |
title_short |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
title_full |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
title_fullStr |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
title_full_unstemmed |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
title_sort |
Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study |
author |
Vaz-de-Melo,Renan Oliveira |
author_facet |
Vaz-de-Melo,Renan Oliveira Giollo-Júnior,Luiz Tadeu Martinelli,Débora Dada Moreno-Júnior,Heitor Mota-Gomes,Marco Antônio Cipullo,José Paulo Yugar-Toledo,Juan Carlos Vilela-Martin,José Fernando |
author_role |
author |
author2 |
Giollo-Júnior,Luiz Tadeu Martinelli,Débora Dada Moreno-Júnior,Heitor Mota-Gomes,Marco Antônio Cipullo,José Paulo Yugar-Toledo,Juan Carlos Vilela-Martin,José Fernando |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Vaz-de-Melo,Renan Oliveira Giollo-Júnior,Luiz Tadeu Martinelli,Débora Dada Moreno-Júnior,Heitor Mota-Gomes,Marco Antônio Cipullo,José Paulo Yugar-Toledo,Juan Carlos Vilela-Martin,José Fernando |
dc.subject.por.fl_str_mv |
Adrenergic beta-antagonists Vasodilator agents Arterial pressure Pulse wave analysis Hypertension |
topic |
Adrenergic beta-antagonists Vasodilator agents Arterial pressure Pulse wave analysis Hypertension |
description |
CONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients.DESIGN AND SETTING: Experimental single cohort study conducted in the outpatient clinic of a university hospital.METHODS: Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol.RESULTS: 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment.CONCLUSIONS: Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000500290 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000500290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2014.1325704 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.132 n.5 2014 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209263963602944 |