Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution

Detalhes bibliográficos
Autor(a) principal: Santos,Kelli Borges
Data de Publicação: 2012
Outros Autores: Hallack Neto,Abrahão Elias, Silva,Girlene Alves, Atalla,Angelo, Abreu,Marcus Matta, Ribeiro,Luiz Cláudio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000100003
Resumo: CONTEXT AND OBJECTIVE: Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases. Although HSCT has helped to improve patient survival, the risk of developing infection during hospitalization is an important cause of morbidity and mortality. This study aimed to analyze the infection profile during hospitalization and the associated risk factors among patients undergoing autologous HSCT at the University Hospital, Universidade Federal de Juiz de Fora. DESIGN AND SETTING: This was a cross-sectional study on patients undergoing autologous HSCT at a public university hospital. METHODS: Patients with febrile neutropenia between 2004 and 2009 were retrospectively evaluated regarding their infection profile and associated risk factors. RESULTS: Infection occurred in 57.2% of 112 patients with febrile neutropenia. The main source of infection was the central venous catheter (25.9%). Infection was chiefly due to Gram-positive bacteria, although Gram-negative-related infections were more severe and caused a higher death rate. Sex, age, skin color, nutritional status and underlying disease were not associated with the development of infection. Patients with severe mucositis (Grades III and IV) had a higher infection rate (P < 0.001). Patients who developed pulmonary complications during hospitalization had higher infection rates (P = 0.002). Infection was the main cause of death (57.1%) in the study sample. CONCLUSION: Strategies aimed at reducing infection-related mortality rates among patients undergoing autologous HSCT are necessary.
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spelling Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institutionHematopoietic stem cell transplantationTransplantation, autologousInfectionRisk factorsInfection controlCONTEXT AND OBJECTIVE: Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases. Although HSCT has helped to improve patient survival, the risk of developing infection during hospitalization is an important cause of morbidity and mortality. This study aimed to analyze the infection profile during hospitalization and the associated risk factors among patients undergoing autologous HSCT at the University Hospital, Universidade Federal de Juiz de Fora. DESIGN AND SETTING: This was a cross-sectional study on patients undergoing autologous HSCT at a public university hospital. METHODS: Patients with febrile neutropenia between 2004 and 2009 were retrospectively evaluated regarding their infection profile and associated risk factors. RESULTS: Infection occurred in 57.2% of 112 patients with febrile neutropenia. The main source of infection was the central venous catheter (25.9%). Infection was chiefly due to Gram-positive bacteria, although Gram-negative-related infections were more severe and caused a higher death rate. Sex, age, skin color, nutritional status and underlying disease were not associated with the development of infection. Patients with severe mucositis (Grades III and IV) had a higher infection rate (P < 0.001). Patients who developed pulmonary complications during hospitalization had higher infection rates (P = 0.002). Infection was the main cause of death (57.1%) in the study sample. CONCLUSION: Strategies aimed at reducing infection-related mortality rates among patients undergoing autologous HSCT are necessary.Associação Paulista de Medicina - APM2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000100003Sao Paulo Medical Journal v.130 n.1 2012reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802012000100003info:eu-repo/semantics/openAccessSantos,Kelli BorgesHallack Neto,Abrahão EliasSilva,Girlene AlvesAtalla,AngeloAbreu,Marcus MattaRibeiro,Luiz Cláudioeng2012-02-13T00:00:00Zoai:scielo:S1516-31802012000100003Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2012-02-13T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
title Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
spellingShingle Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
Santos,Kelli Borges
Hematopoietic stem cell transplantation
Transplantation, autologous
Infection
Risk factors
Infection control
title_short Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
title_full Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
title_fullStr Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
title_full_unstemmed Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
title_sort Infection profile of patients undergoing autologous bone marrow transplantation in a Brazilian institution
author Santos,Kelli Borges
author_facet Santos,Kelli Borges
Hallack Neto,Abrahão Elias
Silva,Girlene Alves
Atalla,Angelo
Abreu,Marcus Matta
Ribeiro,Luiz Cláudio
author_role author
author2 Hallack Neto,Abrahão Elias
Silva,Girlene Alves
Atalla,Angelo
Abreu,Marcus Matta
Ribeiro,Luiz Cláudio
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos,Kelli Borges
Hallack Neto,Abrahão Elias
Silva,Girlene Alves
Atalla,Angelo
Abreu,Marcus Matta
Ribeiro,Luiz Cláudio
dc.subject.por.fl_str_mv Hematopoietic stem cell transplantation
Transplantation, autologous
Infection
Risk factors
Infection control
topic Hematopoietic stem cell transplantation
Transplantation, autologous
Infection
Risk factors
Infection control
description CONTEXT AND OBJECTIVE: Hematopoietic stem cell transplantation (HSCT) has been widely used for treating oncological and hematological diseases. Although HSCT has helped to improve patient survival, the risk of developing infection during hospitalization is an important cause of morbidity and mortality. This study aimed to analyze the infection profile during hospitalization and the associated risk factors among patients undergoing autologous HSCT at the University Hospital, Universidade Federal de Juiz de Fora. DESIGN AND SETTING: This was a cross-sectional study on patients undergoing autologous HSCT at a public university hospital. METHODS: Patients with febrile neutropenia between 2004 and 2009 were retrospectively evaluated regarding their infection profile and associated risk factors. RESULTS: Infection occurred in 57.2% of 112 patients with febrile neutropenia. The main source of infection was the central venous catheter (25.9%). Infection was chiefly due to Gram-positive bacteria, although Gram-negative-related infections were more severe and caused a higher death rate. Sex, age, skin color, nutritional status and underlying disease were not associated with the development of infection. Patients with severe mucositis (Grades III and IV) had a higher infection rate (P < 0.001). Patients who developed pulmonary complications during hospitalization had higher infection rates (P = 0.002). Infection was the main cause of death (57.1%) in the study sample. CONCLUSION: Strategies aimed at reducing infection-related mortality rates among patients undergoing autologous HSCT are necessary.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802012000100003
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1516-31802012000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.130 n.1 2012
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
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institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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