Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200005 |
Resumo: | This study was designed to determine the effects of phlebotomy on iron body contents and coagulation tests of COPD patients with polycythemia secondary to hypoxemia. Seventeen patients with COPD and hematocrits higher than 54 percent (mean Hct: 57 ± 0.49 percent ), who had not received anti-inflammatory or antiplatelet aggregation agents recently. Their mean forced expiratory volume at 1 second (FEV1) was 0.92 ± 0.11 L. Intervention: Blood work was collected to evaluate the following: serum iron and ferritin levels, total iron binding capacity, transferrin saturation index, fibrinogen plasma levels, activated partial thromboplastin time, platelet count, platelet aggregation measurements, and thromboelastography coagulation parameters. The blood samples were obtained before and about 7 days after the hematocrit correction by 300-400 ml phlebotomies done every other day. The mean number of phlebotomies done for each patient was 4.4. Postphlebotomy iron serum levels decreased from 90.1 ± 14.8 to 59.7 ± 9.9 mg/dl and the ferritin serum levels from 133.8 ± 37.9 to 70.8 ± 32.7 ng/ml (p< 0.05). Regarding the coagulation studies, there were significant increases in the platelet count, from 227,300 ± 13,900 to 312,500 ± 30,200 per mm³, and in the maximum clot amplitude (a) obtained by thromboelastography ( from 53.6 ± 1.4 percent to 60.4 ± 1.1 percent). The coagulation time (k) of the thromboelastography also decreased significantly, from 7.5 ± 0.7mm prephlebotomy to 4.5 ± 0.3mm postphlebotomy. Although the coagulation changes were small amount, the observed significant decrease in iron contents may have important clinical implications. |
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Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomiesSecondary polycythemiarepetitive phlebotomiesiron deficiencycoagulationchronic obstructive pulmonary diseaseThis study was designed to determine the effects of phlebotomy on iron body contents and coagulation tests of COPD patients with polycythemia secondary to hypoxemia. Seventeen patients with COPD and hematocrits higher than 54 percent (mean Hct: 57 ± 0.49 percent ), who had not received anti-inflammatory or antiplatelet aggregation agents recently. Their mean forced expiratory volume at 1 second (FEV1) was 0.92 ± 0.11 L. Intervention: Blood work was collected to evaluate the following: serum iron and ferritin levels, total iron binding capacity, transferrin saturation index, fibrinogen plasma levels, activated partial thromboplastin time, platelet count, platelet aggregation measurements, and thromboelastography coagulation parameters. The blood samples were obtained before and about 7 days after the hematocrit correction by 300-400 ml phlebotomies done every other day. The mean number of phlebotomies done for each patient was 4.4. Postphlebotomy iron serum levels decreased from 90.1 ± 14.8 to 59.7 ± 9.9 mg/dl and the ferritin serum levels from 133.8 ± 37.9 to 70.8 ± 32.7 ng/ml (p< 0.05). Regarding the coagulation studies, there were significant increases in the platelet count, from 227,300 ± 13,900 to 312,500 ± 30,200 per mm³, and in the maximum clot amplitude (a) obtained by thromboelastography ( from 53.6 ± 1.4 percent to 60.4 ± 1.1 percent). The coagulation time (k) of the thromboelastography also decreased significantly, from 7.5 ± 0.7mm prephlebotomy to 4.5 ± 0.3mm postphlebotomy. Although the coagulation changes were small amount, the observed significant decrease in iron contents may have important clinical implications.Associação Paulista de Medicina - APM1997-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200005Sao Paulo Medical Journal v.115 n.2 1997reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801997000200005info:eu-repo/semantics/openAccessMartinez,José Antônio BaddiniGuerra,Celso Carlos de CamposNery,Luiz EduardoJardim,José Roberto de Britoeng2008-11-06T00:00:00Zoai:scielo:S1516-31801997000200005Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2008-11-06T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
title |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
spellingShingle |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies Martinez,José Antônio Baddini Secondary polycythemia repetitive phlebotomies iron deficiency coagulation chronic obstructive pulmonary disease |
title_short |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
title_full |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
title_fullStr |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
title_full_unstemmed |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
title_sort |
Iron stores and coagulation parameters in patients with hypoxemic polycythemia secondary to chronic obstructive pulmonary disease: the effect of phlebotomies |
author |
Martinez,José Antônio Baddini |
author_facet |
Martinez,José Antônio Baddini Guerra,Celso Carlos de Campos Nery,Luiz Eduardo Jardim,José Roberto de Brito |
author_role |
author |
author2 |
Guerra,Celso Carlos de Campos Nery,Luiz Eduardo Jardim,José Roberto de Brito |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Martinez,José Antônio Baddini Guerra,Celso Carlos de Campos Nery,Luiz Eduardo Jardim,José Roberto de Brito |
dc.subject.por.fl_str_mv |
Secondary polycythemia repetitive phlebotomies iron deficiency coagulation chronic obstructive pulmonary disease |
topic |
Secondary polycythemia repetitive phlebotomies iron deficiency coagulation chronic obstructive pulmonary disease |
description |
This study was designed to determine the effects of phlebotomy on iron body contents and coagulation tests of COPD patients with polycythemia secondary to hypoxemia. Seventeen patients with COPD and hematocrits higher than 54 percent (mean Hct: 57 ± 0.49 percent ), who had not received anti-inflammatory or antiplatelet aggregation agents recently. Their mean forced expiratory volume at 1 second (FEV1) was 0.92 ± 0.11 L. Intervention: Blood work was collected to evaluate the following: serum iron and ferritin levels, total iron binding capacity, transferrin saturation index, fibrinogen plasma levels, activated partial thromboplastin time, platelet count, platelet aggregation measurements, and thromboelastography coagulation parameters. The blood samples were obtained before and about 7 days after the hematocrit correction by 300-400 ml phlebotomies done every other day. The mean number of phlebotomies done for each patient was 4.4. Postphlebotomy iron serum levels decreased from 90.1 ± 14.8 to 59.7 ± 9.9 mg/dl and the ferritin serum levels from 133.8 ± 37.9 to 70.8 ± 32.7 ng/ml (p< 0.05). Regarding the coagulation studies, there were significant increases in the platelet count, from 227,300 ± 13,900 to 312,500 ± 30,200 per mm³, and in the maximum clot amplitude (a) obtained by thromboelastography ( from 53.6 ± 1.4 percent to 60.4 ± 1.1 percent). The coagulation time (k) of the thromboelastography also decreased significantly, from 7.5 ± 0.7mm prephlebotomy to 4.5 ± 0.3mm postphlebotomy. Although the coagulation changes were small amount, the observed significant decrease in iron contents may have important clinical implications. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31801997000200005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.115 n.2 1997 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209259564826624 |