Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review

Detalhes bibliográficos
Autor(a) principal: Chagas,Stephanye Carolyne Christino
Data de Publicação: 2021
Outros Autores: Moreira,Francisca Sueli Monte, Barbosa,Irla Carla França, Leal Júnior,Osvaldo de Sousa, Leal,Leila Bastos, Santana,Davi Pereira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000100081
Resumo: ABSTRACT BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative review developed by a research group at a public university in Recife (PE), Brazil. METHODS: We searched the literature on the use of cholecalciferol for prevention or treatment of COVID-19, using the MEDLINE and LILACS databases, with the keywords “vitamin D”, “cholecalciferol”, “SARS-CoV-2”, “COVID-19” and “coronavirus”, from January 1, 2020, to June 10, 2020. Narrative reviews, cohort studies and ecological studies were selected. RESULTS: We retrieved 32 references, of which 8 were considered eligible for intensive review and critical analysis. These comprised five narrative reviews, two observational studies and one protocol proposal. Most of the studies selected reported positive effects from use of vitamin D for prevention or treatment of COVID-19. However, there was little quantitative data to assess the real impact of using this vitamin as an intervention against this disease. CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.
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spelling Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative reviewVitamin DCholecalciferolCOVID-19 [supplementary concept]Severe acute respiratory syndrome coronavirus 2 [supplementary concept]CoronavirusSARS-CoV-2Viral infectionPreventionTreatment.ABSTRACT BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative review developed by a research group at a public university in Recife (PE), Brazil. METHODS: We searched the literature on the use of cholecalciferol for prevention or treatment of COVID-19, using the MEDLINE and LILACS databases, with the keywords “vitamin D”, “cholecalciferol”, “SARS-CoV-2”, “COVID-19” and “coronavirus”, from January 1, 2020, to June 10, 2020. Narrative reviews, cohort studies and ecological studies were selected. RESULTS: We retrieved 32 references, of which 8 were considered eligible for intensive review and critical analysis. These comprised five narrative reviews, two observational studies and one protocol proposal. Most of the studies selected reported positive effects from use of vitamin D for prevention or treatment of COVID-19. However, there was little quantitative data to assess the real impact of using this vitamin as an intervention against this disease. CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.Associação Paulista de Medicina - APM2021-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000100081Sao Paulo Medical Journal v.139 n.1 2021reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2020.0532.02112020info:eu-repo/semantics/openAccessChagas,Stephanye Carolyne ChristinoMoreira,Francisca Sueli MonteBarbosa,Irla Carla FrançaLeal Júnior,Osvaldo de SousaLeal,Leila BastosSantana,Davi Pereira deeng2021-02-22T00:00:00Zoai:scielo:S1516-31802021000100081Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2021-02-22T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
spellingShingle Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
Chagas,Stephanye Carolyne Christino
Vitamin D
Cholecalciferol
COVID-19 [supplementary concept]
Severe acute respiratory syndrome coronavirus 2 [supplementary concept]
Coronavirus
SARS-CoV-2
Viral infection
Prevention
Treatment.
title_short Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_full Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_fullStr Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_full_unstemmed Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_sort Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
author Chagas,Stephanye Carolyne Christino
author_facet Chagas,Stephanye Carolyne Christino
Moreira,Francisca Sueli Monte
Barbosa,Irla Carla França
Leal Júnior,Osvaldo de Sousa
Leal,Leila Bastos
Santana,Davi Pereira de
author_role author
author2 Moreira,Francisca Sueli Monte
Barbosa,Irla Carla França
Leal Júnior,Osvaldo de Sousa
Leal,Leila Bastos
Santana,Davi Pereira de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Chagas,Stephanye Carolyne Christino
Moreira,Francisca Sueli Monte
Barbosa,Irla Carla França
Leal Júnior,Osvaldo de Sousa
Leal,Leila Bastos
Santana,Davi Pereira de
dc.subject.por.fl_str_mv Vitamin D
Cholecalciferol
COVID-19 [supplementary concept]
Severe acute respiratory syndrome coronavirus 2 [supplementary concept]
Coronavirus
SARS-CoV-2
Viral infection
Prevention
Treatment.
topic Vitamin D
Cholecalciferol
COVID-19 [supplementary concept]
Severe acute respiratory syndrome coronavirus 2 [supplementary concept]
Coronavirus
SARS-CoV-2
Viral infection
Prevention
Treatment.
description ABSTRACT BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative review developed by a research group at a public university in Recife (PE), Brazil. METHODS: We searched the literature on the use of cholecalciferol for prevention or treatment of COVID-19, using the MEDLINE and LILACS databases, with the keywords “vitamin D”, “cholecalciferol”, “SARS-CoV-2”, “COVID-19” and “coronavirus”, from January 1, 2020, to June 10, 2020. Narrative reviews, cohort studies and ecological studies were selected. RESULTS: We retrieved 32 references, of which 8 were considered eligible for intensive review and critical analysis. These comprised five narrative reviews, two observational studies and one protocol proposal. Most of the studies selected reported positive effects from use of vitamin D for prevention or treatment of COVID-19. However, there was little quantitative data to assess the real impact of using this vitamin as an intervention against this disease. CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000100081
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1516-3180.2020.0532.02112020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.139 n.1 2021
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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