Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600006 |
Resumo: | CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation. The objectives here were to analyze CD83 antigen expression in human breast fibroadenoma and breast tissue adjacent to the lesion and to identify clinical factors that might influence this expression. DESIGN AND SETTING: This was a retrospective study at a public university hospital, in which 29 histopathological samples of breast fibroadenoma and adjacent breast tissue, from 28 women of reproductive age, were analyzed. METHODS: The immunohistochemistry method was used to analyze the cell expression of the antigen. The antigen expression in the cells was evaluated by means of random manual counting using an optical microscope. RESULTS: Positive expression of the CD83 antigen in the epithelial cells of the fibroadenoma (365.52; standard deviation ± 133.13) in relation to the adjacent breast tissue cells (189.59; standard deviation ± 140.75) was statistically larger (P < 0.001). Several clinical features were analyzed, but only parity was shown to influence CD83 antigen expression in the adjacent breast tissue, such that positive expression was more evident in nulliparous women (P = 0.042). CONCLUSIONS: The expression of the CD83 antigen in the fibroadenoma was positive and greater than in the adjacent breast tissue. Positive expression of the antigen in the adjacent breast tissue was influenced by parity, and was significantly more evident in nulliparous women. |
id |
APM-1_8afc1e91f88445d479b8b083280a7dd1 |
---|---|
oai_identifier_str |
oai:scielo:S1516-31802011000600006 |
network_acronym_str |
APM-1 |
network_name_str |
São Paulo medical journal (Online) |
repository_id_str |
|
spelling |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissueFibroadenomaAntigen-antibody complexAntigen-presenting cellsMajor histocompatibility complexImmunohistochemistryFibroadenomaCONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation. The objectives here were to analyze CD83 antigen expression in human breast fibroadenoma and breast tissue adjacent to the lesion and to identify clinical factors that might influence this expression. DESIGN AND SETTING: This was a retrospective study at a public university hospital, in which 29 histopathological samples of breast fibroadenoma and adjacent breast tissue, from 28 women of reproductive age, were analyzed. METHODS: The immunohistochemistry method was used to analyze the cell expression of the antigen. The antigen expression in the cells was evaluated by means of random manual counting using an optical microscope. RESULTS: Positive expression of the CD83 antigen in the epithelial cells of the fibroadenoma (365.52; standard deviation ± 133.13) in relation to the adjacent breast tissue cells (189.59; standard deviation ± 140.75) was statistically larger (P < 0.001). Several clinical features were analyzed, but only parity was shown to influence CD83 antigen expression in the adjacent breast tissue, such that positive expression was more evident in nulliparous women (P = 0.042). CONCLUSIONS: The expression of the CD83 antigen in the fibroadenoma was positive and greater than in the adjacent breast tissue. Positive expression of the antigen in the adjacent breast tissue was influenced by parity, and was significantly more evident in nulliparous women.Associação Paulista de Medicina - APM2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600006Sao Paulo Medical Journal v.129 n.6 2011reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802011000600006info:eu-repo/semantics/openAccessBorges,Marcus NascimentoFacina,GilSilva,Ismael Dale Cotrin GuerreiroWaitzberg,Angela Flávia LogulloNazario,Afonso Celso Pintoeng2012-01-11T00:00:00Zoai:scielo:S1516-31802011000600006Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2012-01-11T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
title |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
spellingShingle |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue Borges,Marcus Nascimento Fibroadenoma Antigen-antibody complex Antigen-presenting cells Major histocompatibility complex Immunohistochemistry Fibroadenoma |
title_short |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
title_full |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
title_fullStr |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
title_full_unstemmed |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
title_sort |
Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue |
author |
Borges,Marcus Nascimento |
author_facet |
Borges,Marcus Nascimento Facina,Gil Silva,Ismael Dale Cotrin Guerreiro Waitzberg,Angela Flávia Logullo Nazario,Afonso Celso Pinto |
author_role |
author |
author2 |
Facina,Gil Silva,Ismael Dale Cotrin Guerreiro Waitzberg,Angela Flávia Logullo Nazario,Afonso Celso Pinto |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Borges,Marcus Nascimento Facina,Gil Silva,Ismael Dale Cotrin Guerreiro Waitzberg,Angela Flávia Logullo Nazario,Afonso Celso Pinto |
dc.subject.por.fl_str_mv |
Fibroadenoma Antigen-antibody complex Antigen-presenting cells Major histocompatibility complex Immunohistochemistry Fibroadenoma |
topic |
Fibroadenoma Antigen-antibody complex Antigen-presenting cells Major histocompatibility complex Immunohistochemistry Fibroadenoma |
description |
CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation. The objectives here were to analyze CD83 antigen expression in human breast fibroadenoma and breast tissue adjacent to the lesion and to identify clinical factors that might influence this expression. DESIGN AND SETTING: This was a retrospective study at a public university hospital, in which 29 histopathological samples of breast fibroadenoma and adjacent breast tissue, from 28 women of reproductive age, were analyzed. METHODS: The immunohistochemistry method was used to analyze the cell expression of the antigen. The antigen expression in the cells was evaluated by means of random manual counting using an optical microscope. RESULTS: Positive expression of the CD83 antigen in the epithelial cells of the fibroadenoma (365.52; standard deviation ± 133.13) in relation to the adjacent breast tissue cells (189.59; standard deviation ± 140.75) was statistically larger (P < 0.001). Several clinical features were analyzed, but only parity was shown to influence CD83 antigen expression in the adjacent breast tissue, such that positive expression was more evident in nulliparous women (P = 0.042). CONCLUSIONS: The expression of the CD83 antigen in the fibroadenoma was positive and greater than in the adjacent breast tissue. Positive expression of the antigen in the adjacent breast tissue was influenced by parity, and was significantly more evident in nulliparous women. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31802011000600006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.129 n.6 2011 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209263063924736 |