Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods

Detalhes bibliográficos
Autor(a) principal: Montoro,Antonio Franco
Data de Publicação: 1997
Outros Autores: Giannotti Filho,Osvaldo, Monteiro,Darcy Marchione, Montoro,Flávio Franco, Pinho,Maria Aparecida, Figueiredo,Marco Túlio Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004
Resumo: Alternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1% with estrogen and 48.5% with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32% with ER and increased to 57% with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma.
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spelling Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methodsBreast carcinomaPrognosisHormonal receptors assaysCorrelation of methodsAlternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1% with estrogen and 48.5% with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32% with ER and increased to 57% with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma.Associação Paulista de Medicina - APM1997-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004Sao Paulo Medical Journal v.115 n.4 1997reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801997000400004info:eu-repo/semantics/openAccessMontoro,Antonio FrancoGiannotti Filho,OsvaldoMonteiro,Darcy MarchioneMontoro,Flávio FrancoPinho,Maria AparecidaFigueiredo,Marco Túlio Assiseng2008-11-05T00:00:00Zoai:scielo:S1516-31801997000400004Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2008-11-05T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
title Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
spellingShingle Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
Montoro,Antonio Franco
Breast carcinoma
Prognosis
Hormonal receptors assays
Correlation of methods
title_short Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
title_full Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
title_fullStr Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
title_full_unstemmed Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
title_sort Hormonal receptors in mammary carcinoma: comparison between quantitative and qualitative methods
author Montoro,Antonio Franco
author_facet Montoro,Antonio Franco
Giannotti Filho,Osvaldo
Monteiro,Darcy Marchione
Montoro,Flávio Franco
Pinho,Maria Aparecida
Figueiredo,Marco Túlio Assis
author_role author
author2 Giannotti Filho,Osvaldo
Monteiro,Darcy Marchione
Montoro,Flávio Franco
Pinho,Maria Aparecida
Figueiredo,Marco Túlio Assis
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Montoro,Antonio Franco
Giannotti Filho,Osvaldo
Monteiro,Darcy Marchione
Montoro,Flávio Franco
Pinho,Maria Aparecida
Figueiredo,Marco Túlio Assis
dc.subject.por.fl_str_mv Breast carcinoma
Prognosis
Hormonal receptors assays
Correlation of methods
topic Breast carcinoma
Prognosis
Hormonal receptors assays
Correlation of methods
description Alternatives to the traditional hormone receptor dosages for prognostic evaluation and clinical approach to breast cancer have been proposed for immunohistochemical determinations. For correlation purposes, such procedures were compared in 37 patients presenting 5 to 15 years of survival. Considering 30 fm/mg as the positivity index, the disagreement between both methods reached 35.1% with estrogen and 48.5% with progesterone receptors. When the positiveness level was changed to 20 fm/mg, the discrepancies were reduced to 32% with ER and increased to 57% with PgR. This study leads us to not recommend the immunohistochemical method applied to paraffin sections as an alternative procedure to the dextran-charcoal dosage for prognosis and therapeutic management of mammary carcinoma.
publishDate 1997
dc.date.none.fl_str_mv 1997-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31801997000400004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.115 n.4 1997
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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