Cellular angiofibroma of the vulva: case report with clinicopathological and immunohistochemistry study

• Autor(a) principal: Micheletti,Adilha Misson Rua
• Data de Publicação: 2005
• Outros Autores: Silva,Ana Cristina Araújo Lemos da, Nascimento,Antonio Geraldo, Silva,Cléber Sérgio da, Murta,Eddie Fernando Candido, Adad,Sheila Jorge
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: São Paulo medical journal (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802005000500010
• topic: Angiofibroma; Connective tissue; Mesoderm; Neoplasm; Vulva

CONTEXT: Cellular angiofibroma of the vulva is a rare tumor that was first described in 1997. It occurs in middle-aged women (average age: 47 years), has small size (< 3 cm) and well-circumscribed margins. CASE REPORT: We describe a case in a 51-year-old woman whose preoperative diagnosis was confounded with Bartholin's glandular cyst. The neoplasia was well delimited and made up of three characteristic components: fusiform cells forming small fascicles, numerous blood vessels and adipose tissue interspersed between the fusiform cells. The stroma cells were positive for vimentin and negative for CD34, protein S-100, actin and desmin. The differential diagnoses for this tumor include aggressive angiomyxoma, angiomyofibroblastoma, lipoma of fusiform cells, solitary fibrous tumor, perineurioma and leiomyoma.