Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Applied Science Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/4017 |
Resumo: | The recent expansion of the Brazilian agricultural industry owes much to the insertion of the agrochemical compositions in the field, this advent strengthened the techniques of defense against pests and made many cultures viable. Especially after the Green Revolution (1950s), these substances began to be used on a large scale in the world, making Brazil the most uncomfortable consumer of pesticides in the world in 2008. These compositions worry about the varied effects that can cause, as sudden or chronic intoxications. And when we talk about chronic complications, we can mention the carcinogenesis. In this work, we analyzed an acaricide used in crops of beans, cotton, potatoes, etc. Abamectin 1-B (C47H70O14). This compound draws attention to the fact that it does not yet have a definitive classification in the International Agency for Research on Cancer (IARC), an agency that monitors and classifies substances as to their carcinogenic potential. Another relevant fact is the presence of Abamectin-1b among the active ingredients of pesticides under re-evaluation in ANVISA (National Agency for Sanitary Surveillance), the Brazilian agency responsible for the use and trade of these materials. Notably, this raises a scientific concern about the effects caused by the compound as toxicity and carcinogenicity, for example. Abamectin-1b is an insecticide, acaricide and anthelmintic of wide application in Brazilian agriculture, in this sense the elucidation of its effects requires urgency. In the present work, we evaluated the carcinogenic influence of this compound, according to the Logarithm interpretation of the Partition Coefficient, a given indicator of the relationship between the compound (lipophilia), and therefore a descriptor of its invasive power. The results were calculated using the software ALOGPS 2.1 and compared with other values already established in the literature. The results found for Abamectin-1B indicated a high lipophilia and low solubility of the substance, therefore considerable tendency to transpose the cell membrane. This is preliminary information that integrates a broader model of carcinogenic evaluation. |
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Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidadeCarcinogenicityAgrotoxicAnvisaThe recent expansion of the Brazilian agricultural industry owes much to the insertion of the agrochemical compositions in the field, this advent strengthened the techniques of defense against pests and made many cultures viable. Especially after the Green Revolution (1950s), these substances began to be used on a large scale in the world, making Brazil the most uncomfortable consumer of pesticides in the world in 2008. These compositions worry about the varied effects that can cause, as sudden or chronic intoxications. And when we talk about chronic complications, we can mention the carcinogenesis. In this work, we analyzed an acaricide used in crops of beans, cotton, potatoes, etc. Abamectin 1-B (C47H70O14). This compound draws attention to the fact that it does not yet have a definitive classification in the International Agency for Research on Cancer (IARC), an agency that monitors and classifies substances as to their carcinogenic potential. Another relevant fact is the presence of Abamectin-1b among the active ingredients of pesticides under re-evaluation in ANVISA (National Agency for Sanitary Surveillance), the Brazilian agency responsible for the use and trade of these materials. Notably, this raises a scientific concern about the effects caused by the compound as toxicity and carcinogenicity, for example. Abamectin-1b is an insecticide, acaricide and anthelmintic of wide application in Brazilian agriculture, in this sense the elucidation of its effects requires urgency. In the present work, we evaluated the carcinogenic influence of this compound, according to the Logarithm interpretation of the Partition Coefficient, a given indicator of the relationship between the compound (lipophilia), and therefore a descriptor of its invasive power. The results were calculated using the software ALOGPS 2.1 and compared with other values already established in the literature. The results found for Abamectin-1B indicated a high lipophilia and low solubility of the substance, therefore considerable tendency to transpose the cell membrane. This is preliminary information that integrates a broader model of carcinogenic evaluation.Brazilian Journals Publicações de Periódicos e Editora Ltda.2019-10-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/401710.34115/basrv3n5-023Brazilian Applied Science Review; Vol. 3 No. 5 (2019); 2212-2220Brazilian Applied Science Review; v. 3 n. 5 (2019); 2212-22202595-36212595-362110.34115/basr.v3i5reponame:Brazilian Applied Science Reviewinstname:Brazilian Journals Publicações de Periódicos e Editora Ltdainstacron:FIEPporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/4017/3810Copyright (c) 2019 Brazilian Applied Science Reviewinfo:eu-repo/semantics/openAccessRocha, Adriano Santos daAzevedo, Glaucia Santos Dias deSilva, Edilene da SilvaCardoso, Gilsivani HoffmannLoureiro, Cleber de Nazare2019-10-31T11:29:32Zoai:ojs2.ojs.brazilianjournals.com.br:article/4017Revistahttps://www.brazilianjournals.com/index.php/BASRPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/oaibrazilianasr@yahoo.com || brazilianasr@yahoo.com2595-36212595-3621opendoar:2019-10-31T11:29:32Brazilian Applied Science Review - Brazilian Journals Publicações de Periódicos e Editora Ltdafalse |
dc.title.none.fl_str_mv |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
title |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
spellingShingle |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade Rocha, Adriano Santos da Carcinogenicity Agrotoxic Anvisa |
title_short |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
title_full |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
title_fullStr |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
title_full_unstemmed |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
title_sort |
Membrane-acaricide interface described by solubility/ Interface membrana-acaricida descritada por solubilidade |
author |
Rocha, Adriano Santos da |
author_facet |
Rocha, Adriano Santos da Azevedo, Glaucia Santos Dias de Silva, Edilene da Silva Cardoso, Gilsivani Hoffmann Loureiro, Cleber de Nazare |
author_role |
author |
author2 |
Azevedo, Glaucia Santos Dias de Silva, Edilene da Silva Cardoso, Gilsivani Hoffmann Loureiro, Cleber de Nazare |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rocha, Adriano Santos da Azevedo, Glaucia Santos Dias de Silva, Edilene da Silva Cardoso, Gilsivani Hoffmann Loureiro, Cleber de Nazare |
dc.subject.por.fl_str_mv |
Carcinogenicity Agrotoxic Anvisa |
topic |
Carcinogenicity Agrotoxic Anvisa |
description |
The recent expansion of the Brazilian agricultural industry owes much to the insertion of the agrochemical compositions in the field, this advent strengthened the techniques of defense against pests and made many cultures viable. Especially after the Green Revolution (1950s), these substances began to be used on a large scale in the world, making Brazil the most uncomfortable consumer of pesticides in the world in 2008. These compositions worry about the varied effects that can cause, as sudden or chronic intoxications. And when we talk about chronic complications, we can mention the carcinogenesis. In this work, we analyzed an acaricide used in crops of beans, cotton, potatoes, etc. Abamectin 1-B (C47H70O14). This compound draws attention to the fact that it does not yet have a definitive classification in the International Agency for Research on Cancer (IARC), an agency that monitors and classifies substances as to their carcinogenic potential. Another relevant fact is the presence of Abamectin-1b among the active ingredients of pesticides under re-evaluation in ANVISA (National Agency for Sanitary Surveillance), the Brazilian agency responsible for the use and trade of these materials. Notably, this raises a scientific concern about the effects caused by the compound as toxicity and carcinogenicity, for example. Abamectin-1b is an insecticide, acaricide and anthelmintic of wide application in Brazilian agriculture, in this sense the elucidation of its effects requires urgency. In the present work, we evaluated the carcinogenic influence of this compound, according to the Logarithm interpretation of the Partition Coefficient, a given indicator of the relationship between the compound (lipophilia), and therefore a descriptor of its invasive power. The results were calculated using the software ALOGPS 2.1 and compared with other values already established in the literature. The results found for Abamectin-1B indicated a high lipophilia and low solubility of the substance, therefore considerable tendency to transpose the cell membrane. This is preliminary information that integrates a broader model of carcinogenic evaluation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/4017 10.34115/basrv3n5-023 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/4017 |
identifier_str_mv |
10.34115/basrv3n5-023 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/4017/3810 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Applied Science Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Applied Science Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Applied Science Review; Vol. 3 No. 5 (2019); 2212-2220 Brazilian Applied Science Review; v. 3 n. 5 (2019); 2212-2220 2595-3621 2595-3621 10.34115/basr.v3i5 reponame:Brazilian Applied Science Review instname:Brazilian Journals Publicações de Periódicos e Editora Ltda instacron:FIEP |
instname_str |
Brazilian Journals Publicações de Periódicos e Editora Ltda |
instacron_str |
FIEP |
institution |
FIEP |
reponame_str |
Brazilian Applied Science Review |
collection |
Brazilian Applied Science Review |
repository.name.fl_str_mv |
Brazilian Applied Science Review - Brazilian Journals Publicações de Periódicos e Editora Ltda |
repository.mail.fl_str_mv |
brazilianasr@yahoo.com || brazilianasr@yahoo.com |
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1797240006113230848 |