Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina

Detalhes bibliográficos
Autor(a) principal: Marcelos, Priscylla Gonçalves Correia-Leite de
Data de Publicação: 2020
Outros Autores: Regueira, Luciana Silva, Santiago-Jaegger, Isabela Maria, Evêncio-Neto, Joaquim, Baratella-Evêncio, Liriane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Health Review
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8551
Resumo: Introduction: Serotonin is a neurotransmitter implicated on the control of several bodies roles including the regulation of circadian rhythm, of sleepiness, body temperature, motor and cognitive activities and of growth and development of tissues during embryogenesis. Objective: The aim of the present study is to assay the morphological aspects of the root dentin of upper first molars from pups of rats that were treated with fluoxetine in pregnancy. Methodology: For such, we conducted a random experimental study by using used 12 Wistar pregnant rats divided into three groups: C, FX and FL group. From the first to the 21 day of pregnancy, the rats received saline solution or fluoxetine hydrochloride solution, subcutaneously, according to the group to which they belonged. Subsequently, the offspring of animals was divided into subsets according to the age of tooth germ development to be studied: C20 and C45 (control group of 20 and 45 days of age); FL20 and FL45 (treated group with fluoxetine 10 mg/kg body weight of 20 and 45 days of life) and FX20 and FX45 (treated group with fluoxetine 20 mg/kg body weight of 20 and 45 days old). The thickness of root dentin, predentin thickness and length of odontoblasts were analyzed at the offspring samples. The data were tabulated and statistical values were performed with a significance level p < 0,05. Results/Conclusion: Studies have shown significant changes in dentinogenesis root of the groups treated with fluoxetine at doses of 10 and 20 mg / kg body weight during pregnancy.
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spelling Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetinaFluoxetineDental GermSerotoninIntroduction: Serotonin is a neurotransmitter implicated on the control of several bodies roles including the regulation of circadian rhythm, of sleepiness, body temperature, motor and cognitive activities and of growth and development of tissues during embryogenesis. Objective: The aim of the present study is to assay the morphological aspects of the root dentin of upper first molars from pups of rats that were treated with fluoxetine in pregnancy. Methodology: For such, we conducted a random experimental study by using used 12 Wistar pregnant rats divided into three groups: C, FX and FL group. From the first to the 21 day of pregnancy, the rats received saline solution or fluoxetine hydrochloride solution, subcutaneously, according to the group to which they belonged. Subsequently, the offspring of animals was divided into subsets according to the age of tooth germ development to be studied: C20 and C45 (control group of 20 and 45 days of age); FL20 and FL45 (treated group with fluoxetine 10 mg/kg body weight of 20 and 45 days of life) and FX20 and FX45 (treated group with fluoxetine 20 mg/kg body weight of 20 and 45 days old). The thickness of root dentin, predentin thickness and length of odontoblasts were analyzed at the offspring samples. The data were tabulated and statistical values were performed with a significance level p < 0,05. Results/Conclusion: Studies have shown significant changes in dentinogenesis root of the groups treated with fluoxetine at doses of 10 and 20 mg / kg body weight during pregnancy.Brazilian Journals Publicações de Periódicos e Editora Ltda.2020-04-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/855110.34119/bjhrv3n2-131Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 2887-2901Brazilian Journal of Health Review; v. 3 n. 2 (2020); 2887-29012595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8551/7357Copyright (c) 2020 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessMarcelos, Priscylla Gonçalves Correia-Leite deRegueira, Luciana SilvaSantiago-Jaegger, Isabela MariaEvêncio-Neto, JoaquimBaratella-Evêncio, Liriane2020-05-01T15:27:07Zoai:ojs2.ojs.brazilianjournals.com.br:article/8551Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2020-05-01T15:27:07Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false
dc.title.none.fl_str_mv Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
title Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
spellingShingle Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
Marcelos, Priscylla Gonçalves Correia-Leite de
Fluoxetine
Dental Germ
Serotonin
title_short Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
title_full Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
title_fullStr Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
title_full_unstemmed Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
title_sort Histological and histometric aspects of radicular dentinogenesis in upper first molars of fluoxetine treated rats / Aspectos histológicos e histométricos da dentinogênese radicular em primeiros molares superiores dos ratos tratados com fluoxetina
author Marcelos, Priscylla Gonçalves Correia-Leite de
author_facet Marcelos, Priscylla Gonçalves Correia-Leite de
Regueira, Luciana Silva
Santiago-Jaegger, Isabela Maria
Evêncio-Neto, Joaquim
Baratella-Evêncio, Liriane
author_role author
author2 Regueira, Luciana Silva
Santiago-Jaegger, Isabela Maria
Evêncio-Neto, Joaquim
Baratella-Evêncio, Liriane
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Marcelos, Priscylla Gonçalves Correia-Leite de
Regueira, Luciana Silva
Santiago-Jaegger, Isabela Maria
Evêncio-Neto, Joaquim
Baratella-Evêncio, Liriane
dc.subject.por.fl_str_mv Fluoxetine
Dental Germ
Serotonin
topic Fluoxetine
Dental Germ
Serotonin
description Introduction: Serotonin is a neurotransmitter implicated on the control of several bodies roles including the regulation of circadian rhythm, of sleepiness, body temperature, motor and cognitive activities and of growth and development of tissues during embryogenesis. Objective: The aim of the present study is to assay the morphological aspects of the root dentin of upper first molars from pups of rats that were treated with fluoxetine in pregnancy. Methodology: For such, we conducted a random experimental study by using used 12 Wistar pregnant rats divided into three groups: C, FX and FL group. From the first to the 21 day of pregnancy, the rats received saline solution or fluoxetine hydrochloride solution, subcutaneously, according to the group to which they belonged. Subsequently, the offspring of animals was divided into subsets according to the age of tooth germ development to be studied: C20 and C45 (control group of 20 and 45 days of age); FL20 and FL45 (treated group with fluoxetine 10 mg/kg body weight of 20 and 45 days of life) and FX20 and FX45 (treated group with fluoxetine 20 mg/kg body weight of 20 and 45 days old). The thickness of root dentin, predentin thickness and length of odontoblasts were analyzed at the offspring samples. The data were tabulated and statistical values were performed with a significance level p < 0,05. Results/Conclusion: Studies have shown significant changes in dentinogenesis root of the groups treated with fluoxetine at doses of 10 and 20 mg / kg body weight during pregnancy.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-07
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info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8551
10.34119/bjhrv3n2-131
url https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8551
identifier_str_mv 10.34119/bjhrv3n2-131
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8551/7357
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Health Review
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Health Review
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 2887-2901
Brazilian Journal of Health Review; v. 3 n. 2 (2020); 2887-2901
2595-6825
reponame:Brazilian Journal of Health Review
instname:Federação das Indústrias do Estado do Paraná (FIEP)
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instname_str Federação das Indústrias do Estado do Paraná (FIEP)
instacron_str BJRH
institution BJRH
reponame_str Brazilian Journal of Health Review
collection Brazilian Journal of Health Review
repository.name.fl_str_mv Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)
repository.mail.fl_str_mv || brazilianjhr@gmail.com
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