Morphometric analysis of liver and spleen type I and III collagen of autopsied patients with acquired immunodeficiency syndrome / Análise morfométrica do colágeno tipo I e III do fígado e baço de pacientes autopsiados com a Síndrome da Imunodeficiência Adquirida

• Autor(a) principal: Silva, Aline Cristina Souza da
• Data de Publicação: 2019
• Outros Autores: Simões, Anna Luiza Salathiel, Monteiro, Maria Luiza Gonçalves Reis, Martins, Lívia Alves, Teixeira, Vicente de Paula Antunes, Cavellani, Camila Lourencini
• Tipo de documento: Artigo
• Idioma: spa
• Título da fonte: Brazilian Journal of Health Review
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4057
• topic: AIDS; autopsy; spleen; liver.

Acquired Immunodeficiency Syndrome (AIDS) is caused by the Human Immunodeficiency Virus (HIV), a retrovirus capable of invading and replicating in host leucocytes, favoring installation of opportunistic infections and causing important changes in organs such as spleen and liver. The aim of this study was to quantify percentage of type I and III collagen in the spleen and liver of autopsied patients divided in two groups: with AIDS (n=24) and without AIDS (n=24). Quantification of type I and type III collagen was made with Sirius Red and Reticulin stains, respectively, using the image analysis system Leica Qwin Plus®15. From medical records, we retrieved information regarding age, sex, race, Body Mass Index, and spleen and liver weight. We analyzed the data with SigmaStat® 2.03, considering statistically significant values of p<0.05. Patients with AIDS showed higher percentage of type I and type III collagen, with significant difference only between type III in both organs. The virus contributes with increase the amount of type I and type III collagen in liver and spleen of HIV infected patients contributing to morphofunctional changes. These changes may be related to decline of imune function due to viral presence and the increase of these fibers in those organs.