Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26571 |
Resumo: | The world faces today a pandemic of unquestionable importance, caused by an infection with a new enveloped RNA virus that belongs to the Coronaviridae family. The new coronavirus (SARS-CoV 2) uses a glycoprotein present on its surface to bind to and infect host cells that express the angiotensin converting enzyme II (ACE-2). Although different tissues may be targeted by the virus, respiratory complications remain as the main cause of death. It has been demonstrated that Renin-Angiotensin-Aldosterone System (RAAS) inhibitors increase ACE-2 expression in animal models, raising the concern that patients under treatment with these drugs could become more susceptible to COVID-19 complications. Here, we discuss the impact of RAAS inhibitors on COVID-19 outcomes and show that no evidence so far supports that the use of these drugs could pose a risk to SARS-CoV 2-infected patients. In fact, clinical data suggest that RAAS inhibitors may even act in a protective way against COVID-19 complications and should not be discontinued. |
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Brazilian Journal of Health Review |
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Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19SARS-CoV 2AntihypertensivesRenin-Angiotensin-Aldosterone System inhibitorsACE-2. COVID-19.The world faces today a pandemic of unquestionable importance, caused by an infection with a new enveloped RNA virus that belongs to the Coronaviridae family. The new coronavirus (SARS-CoV 2) uses a glycoprotein present on its surface to bind to and infect host cells that express the angiotensin converting enzyme II (ACE-2). Although different tissues may be targeted by the virus, respiratory complications remain as the main cause of death. It has been demonstrated that Renin-Angiotensin-Aldosterone System (RAAS) inhibitors increase ACE-2 expression in animal models, raising the concern that patients under treatment with these drugs could become more susceptible to COVID-19 complications. Here, we discuss the impact of RAAS inhibitors on COVID-19 outcomes and show that no evidence so far supports that the use of these drugs could pose a risk to SARS-CoV 2-infected patients. In fact, clinical data suggest that RAAS inhibitors may even act in a protective way against COVID-19 complications and should not be discontinued. Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-03-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2657110.34119/bjhrv4n2-143Brazilian Journal of Health Review; Vol. 4 No. 2 (2021); 5780-5793Brazilian Journal of Health Review; v. 4 n. 2 (2021); 5780-57932595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26571/21537Copyright (c) 2021 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessde Mattos, Arthur FiorottoBarsotti, Nathália SilveiraAlmeida, Rafael Ribeiro2021-05-31T22:30:35Zoai:ojs2.ojs.brazilianjournals.com.br:article/26571Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2021-05-31T22:30:35Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
title |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
spellingShingle |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 de Mattos, Arthur Fiorotto SARS-CoV 2 Antihypertensives Renin-Angiotensin-Aldosterone System inhibitors ACE-2. COVID-19. |
title_short |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
title_full |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
title_fullStr |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
title_full_unstemmed |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
title_sort |
Renin-angiotensin-aldosterone system inhibitors and covid-19 complications / Inibidores do sistema renina-angiotensina-aldosterona e complicações da covid-19 |
author |
de Mattos, Arthur Fiorotto |
author_facet |
de Mattos, Arthur Fiorotto Barsotti, Nathália Silveira Almeida, Rafael Ribeiro |
author_role |
author |
author2 |
Barsotti, Nathália Silveira Almeida, Rafael Ribeiro |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
de Mattos, Arthur Fiorotto Barsotti, Nathália Silveira Almeida, Rafael Ribeiro |
dc.subject.por.fl_str_mv |
SARS-CoV 2 Antihypertensives Renin-Angiotensin-Aldosterone System inhibitors ACE-2. COVID-19. |
topic |
SARS-CoV 2 Antihypertensives Renin-Angiotensin-Aldosterone System inhibitors ACE-2. COVID-19. |
description |
The world faces today a pandemic of unquestionable importance, caused by an infection with a new enveloped RNA virus that belongs to the Coronaviridae family. The new coronavirus (SARS-CoV 2) uses a glycoprotein present on its surface to bind to and infect host cells that express the angiotensin converting enzyme II (ACE-2). Although different tissues may be targeted by the virus, respiratory complications remain as the main cause of death. It has been demonstrated that Renin-Angiotensin-Aldosterone System (RAAS) inhibitors increase ACE-2 expression in animal models, raising the concern that patients under treatment with these drugs could become more susceptible to COVID-19 complications. Here, we discuss the impact of RAAS inhibitors on COVID-19 outcomes and show that no evidence so far supports that the use of these drugs could pose a risk to SARS-CoV 2-infected patients. In fact, clinical data suggest that RAAS inhibitors may even act in a protective way against COVID-19 complications and should not be discontinued. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26571 10.34119/bjhrv4n2-143 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26571 |
identifier_str_mv |
10.34119/bjhrv4n2-143 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26571/21537 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 4 No. 2 (2021); 5780-5793 Brazilian Journal of Health Review; v. 4 n. 2 (2021); 5780-5793 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240060809052160 |