Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso

Detalhes bibliográficos
Autor(a) principal: Lima, Ricardo Barbosa
Data de Publicação: 2020
Outros Autores: Kameo, Simone Yuriko, Vassilievitch, Andressa Cabral, Fonseca, Tiago Vasconcelos, Amorim, Bruno Ferreira, Costa, Jéssica dos Santos, Silva, Glebson Moura, Sawada, Namie Okino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Health Review
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474
Resumo: Medullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation.
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spelling Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de casoDelayed DiagnosisBreast NeoplasmsMedullary CarcinomaMedical OncologyPrognosisMedullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation.Brazilian Journals Publicações de Periódicos e Editora Ltda.2020-03-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/747410.34119/bjhrv3n2-021Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 1583-1592Brazilian Journal of Health Review; v. 3 n. 2 (2020); 1583-15922595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474/6508Copyright (c) 2020 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessLima, Ricardo BarbosaKameo, Simone YurikoVassilievitch, Andressa CabralFonseca, Tiago VasconcelosAmorim, Bruno FerreiraCosta, Jéssica dos SantosSilva, Glebson MouraSawada, Namie Okino2020-05-01T15:27:07Zoai:ojs2.ojs.brazilianjournals.com.br:article/7474Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2020-05-01T15:27:07Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false
dc.title.none.fl_str_mv Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
title Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
spellingShingle Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
Lima, Ricardo Barbosa
Delayed Diagnosis
Breast Neoplasms
Medullary Carcinoma
Medical Oncology
Prognosis
title_short Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
title_full Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
title_fullStr Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
title_full_unstemmed Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
title_sort Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
author Lima, Ricardo Barbosa
author_facet Lima, Ricardo Barbosa
Kameo, Simone Yuriko
Vassilievitch, Andressa Cabral
Fonseca, Tiago Vasconcelos
Amorim, Bruno Ferreira
Costa, Jéssica dos Santos
Silva, Glebson Moura
Sawada, Namie Okino
author_role author
author2 Kameo, Simone Yuriko
Vassilievitch, Andressa Cabral
Fonseca, Tiago Vasconcelos
Amorim, Bruno Ferreira
Costa, Jéssica dos Santos
Silva, Glebson Moura
Sawada, Namie Okino
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Ricardo Barbosa
Kameo, Simone Yuriko
Vassilievitch, Andressa Cabral
Fonseca, Tiago Vasconcelos
Amorim, Bruno Ferreira
Costa, Jéssica dos Santos
Silva, Glebson Moura
Sawada, Namie Okino
dc.subject.por.fl_str_mv Delayed Diagnosis
Breast Neoplasms
Medullary Carcinoma
Medical Oncology
Prognosis
topic Delayed Diagnosis
Breast Neoplasms
Medullary Carcinoma
Medical Oncology
Prognosis
description Medullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474
10.34119/bjhrv3n2-021
url https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474
identifier_str_mv 10.34119/bjhrv3n2-021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474/6508
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Health Review
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Health Review
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 1583-1592
Brazilian Journal of Health Review; v. 3 n. 2 (2020); 1583-1592
2595-6825
reponame:Brazilian Journal of Health Review
instname:Federação das Indústrias do Estado do Paraná (FIEP)
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instname_str Federação das Indústrias do Estado do Paraná (FIEP)
instacron_str BJRH
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reponame_str Brazilian Journal of Health Review
collection Brazilian Journal of Health Review
repository.name.fl_str_mv Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)
repository.mail.fl_str_mv || brazilianjhr@gmail.com
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