Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474 |
Resumo: | Medullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation. |
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Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de casoDelayed DiagnosisBreast NeoplasmsMedullary CarcinomaMedical OncologyPrognosisMedullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation.Brazilian Journals Publicações de Periódicos e Editora Ltda.2020-03-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/747410.34119/bjhrv3n2-021Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 1583-1592Brazilian Journal of Health Review; v. 3 n. 2 (2020); 1583-15922595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474/6508Copyright (c) 2020 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessLima, Ricardo BarbosaKameo, Simone YurikoVassilievitch, Andressa CabralFonseca, Tiago VasconcelosAmorim, Bruno FerreiraCosta, Jéssica dos SantosSilva, Glebson MouraSawada, Namie Okino2020-05-01T15:27:07Zoai:ojs2.ojs.brazilianjournals.com.br:article/7474Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2020-05-01T15:27:07Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
title |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
spellingShingle |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso Lima, Ricardo Barbosa Delayed Diagnosis Breast Neoplasms Medullary Carcinoma Medical Oncology Prognosis |
title_short |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
title_full |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
title_fullStr |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
title_full_unstemmed |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
title_sort |
Histopathological and immunohistochemical diagnosis of advanced medullary breast carcinoma: case report / Diagnóstico histopatológico e imuno-histoquímico de carcinoma medular avançado de mama: relato de caso |
author |
Lima, Ricardo Barbosa |
author_facet |
Lima, Ricardo Barbosa Kameo, Simone Yuriko Vassilievitch, Andressa Cabral Fonseca, Tiago Vasconcelos Amorim, Bruno Ferreira Costa, Jéssica dos Santos Silva, Glebson Moura Sawada, Namie Okino |
author_role |
author |
author2 |
Kameo, Simone Yuriko Vassilievitch, Andressa Cabral Fonseca, Tiago Vasconcelos Amorim, Bruno Ferreira Costa, Jéssica dos Santos Silva, Glebson Moura Sawada, Namie Okino |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Ricardo Barbosa Kameo, Simone Yuriko Vassilievitch, Andressa Cabral Fonseca, Tiago Vasconcelos Amorim, Bruno Ferreira Costa, Jéssica dos Santos Silva, Glebson Moura Sawada, Namie Okino |
dc.subject.por.fl_str_mv |
Delayed Diagnosis Breast Neoplasms Medullary Carcinoma Medical Oncology Prognosis |
topic |
Delayed Diagnosis Breast Neoplasms Medullary Carcinoma Medical Oncology Prognosis |
description |
Medullary breast carcinoma (CMM) is a rare histological variant of breast cancer. It is a malignant and invasive tumor often observed in young women with large tumor lesions. There are still controversies about survival rates, about the histological pattern and prognosis of the CMM. The aim of this case report is to explain the histopathological diagnosis of a patient diagnosed with advanced medullary breast carcinoma, with emphasis on immunohistochemical findings. In a private oncology service, a 57-year-old woman came for treatment. At the initial clinical examination, it was observed that it presented a necrosis-like right breast tumor, firm on palpation and painful symptoms. An incisional lesion biopsy was performed and the cellular and molecular pattern traced. The report found the presence of advanced medullary breast carcinoma, necrotic malignant lesion in stage IV with bone and renal metastasis. The morphological pattern was composed of large epithelioid cells with pleomorphic and often multinucleated nuclei, with irregular chromatin distribution and atypical mitosis figures. The observed molecular pattern was focal expression of cytokeratin AE1 / AE3, smooth muscle actin, desmin, p63 and CD68. Additionally, the expressions of estrogen receptors, CD34, S-100 and CK8/18 were not observed. The tumor was unresectable and chemotherapy and radiotherapy was chosen to intervene in the disease progression, however, the patient died due to clinical complications resulting from these treatments associated with poor general health. CMM is a rare neoplasm and immunohistochemical studies may contribute to understand how morphological and molecular patterns may influence its clinical presentation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474 10.34119/bjhrv3n2-021 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474 |
identifier_str_mv |
10.34119/bjhrv3n2-021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/7474/6508 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 3 No. 2 (2020); 1583-1592 Brazilian Journal of Health Review; v. 3 n. 2 (2020); 1583-1592 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240050197463040 |