Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48311 |
Resumo: | Neuroendocrine tumor of the uterine cervix is a rare malignant neoplasm, ranging from 0.5 to 5% of uterine cervix cancers. Most of the cases occur in women younger (average 43 years) than those with the usual histologic types. It may occasionally be found associated with spindle cell carcinoma (SCC) and with adenocarcinoma (AC). The relationship between neuroendocrine tumor and human papillomavirus (HVP), specially the high-risk 16 and 18, is demonstrated in several studies. The diagnosis is definitive through the use of histologic hematoxyline-eosine staining, however identification of chromogranin, synaptophysin and enolase by immunohistochemistry plays an important role in the diagnostic doubt. The high tumor aggressiveness is demonstrated by the high percentage of lymph node impairment and early hematogenic invasion at the moment of diagnosis, 68% and 90%, respectively. Survival is short, with an average of 22 months. Multimodal treatment is the most frequently described form. |
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Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literatureneuroendocrine carcinomacervical câncer.Neuroendocrine tumor of the uterine cervix is a rare malignant neoplasm, ranging from 0.5 to 5% of uterine cervix cancers. Most of the cases occur in women younger (average 43 years) than those with the usual histologic types. It may occasionally be found associated with spindle cell carcinoma (SCC) and with adenocarcinoma (AC). The relationship between neuroendocrine tumor and human papillomavirus (HVP), specially the high-risk 16 and 18, is demonstrated in several studies. The diagnosis is definitive through the use of histologic hematoxyline-eosine staining, however identification of chromogranin, synaptophysin and enolase by immunohistochemistry plays an important role in the diagnostic doubt. The high tumor aggressiveness is demonstrated by the high percentage of lymph node impairment and early hematogenic invasion at the moment of diagnosis, 68% and 90%, respectively. Survival is short, with an average of 22 months. Multimodal treatment is the most frequently described form.Brazilian Journals Publicações de Periódicos e Editora Ltda.2022-05-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4831110.34119/bjhrv5n3-164Brazilian Journal of Health Review; Vol. 5 No. 3 (2022); 9970-9976Brazilian Journal of Health Review; v. 5 n. 3 (2022); 9970-99762595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48311/pdfCopyright (c) 2022 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessToledo, Yasmin MeloMendonça, Maria Nathalia Prado SimõesNogueira, Marina de Pádua2022-06-30T18:54:42Zoai:ojs2.ojs.brazilianjournals.com.br:article/48311Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2022-06-30T18:54:42Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
title |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
spellingShingle |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature Toledo, Yasmin Melo neuroendocrine carcinoma cervical câncer. |
title_short |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
title_full |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
title_fullStr |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
title_full_unstemmed |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
title_sort |
Neuroendocrine cervical carcinoma: case report and literature review / Carcinoma neuroendócrino do colo do útero: relato de caso e revisão da literature |
author |
Toledo, Yasmin Melo |
author_facet |
Toledo, Yasmin Melo Mendonça, Maria Nathalia Prado Simões Nogueira, Marina de Pádua |
author_role |
author |
author2 |
Mendonça, Maria Nathalia Prado Simões Nogueira, Marina de Pádua |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Toledo, Yasmin Melo Mendonça, Maria Nathalia Prado Simões Nogueira, Marina de Pádua |
dc.subject.por.fl_str_mv |
neuroendocrine carcinoma cervical câncer. |
topic |
neuroendocrine carcinoma cervical câncer. |
description |
Neuroendocrine tumor of the uterine cervix is a rare malignant neoplasm, ranging from 0.5 to 5% of uterine cervix cancers. Most of the cases occur in women younger (average 43 years) than those with the usual histologic types. It may occasionally be found associated with spindle cell carcinoma (SCC) and with adenocarcinoma (AC). The relationship between neuroendocrine tumor and human papillomavirus (HVP), specially the high-risk 16 and 18, is demonstrated in several studies. The diagnosis is definitive through the use of histologic hematoxyline-eosine staining, however identification of chromogranin, synaptophysin and enolase by immunohistochemistry plays an important role in the diagnostic doubt. The high tumor aggressiveness is demonstrated by the high percentage of lymph node impairment and early hematogenic invasion at the moment of diagnosis, 68% and 90%, respectively. Survival is short, with an average of 22 months. Multimodal treatment is the most frequently described form. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48311 10.34119/bjhrv5n3-164 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48311 |
identifier_str_mv |
10.34119/bjhrv5n3-164 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48311/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 5 No. 3 (2022); 9970-9976 Brazilian Journal of Health Review; v. 5 n. 3 (2022); 9970-9976 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240075481776128 |