Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191 |
Resumo: | Depression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population. |
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Brazilian Journal of Health Review |
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Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population depressiongenetic variantsgenetic polymorphismantidepressantsDepression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-11-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6519110.34119/bjhrv6n6-270Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 30109-30122Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 30109-30122Brazilian Journal of Health Review; v. 6 n. 6 (2023); 30109-301222595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191/46648Santos, Jéssica da SilvaRodrigues, Pedro Augusto Silva dos Santosde Souza Junior, Denilson Luis SilvaSantos, Raphael SilvaCosta, Ryan dos Santosinfo:eu-repo/semantics/openAccess2023-12-01T12:26:45Zoai:ojs2.ojs.brazilianjournals.com.br:article/65191Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-12-01T12:26:45Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
title |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
spellingShingle |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population Santos, Jéssica da Silva depression genetic variants genetic polymorphism antidepressants |
title_short |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
title_full |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
title_fullStr |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
title_full_unstemmed |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
title_sort |
Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population |
author |
Santos, Jéssica da Silva |
author_facet |
Santos, Jéssica da Silva Rodrigues, Pedro Augusto Silva dos Santos de Souza Junior, Denilson Luis Silva Santos, Raphael Silva Costa, Ryan dos Santos |
author_role |
author |
author2 |
Rodrigues, Pedro Augusto Silva dos Santos de Souza Junior, Denilson Luis Silva Santos, Raphael Silva Costa, Ryan dos Santos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Jéssica da Silva Rodrigues, Pedro Augusto Silva dos Santos de Souza Junior, Denilson Luis Silva Santos, Raphael Silva Costa, Ryan dos Santos |
dc.subject.por.fl_str_mv |
depression genetic variants genetic polymorphism antidepressants |
topic |
depression genetic variants genetic polymorphism antidepressants |
description |
Depression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191 10.34119/bjhrv6n6-270 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191 |
identifier_str_mv |
10.34119/bjhrv6n6-270 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191/46648 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 30109-30122 Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 30109-30122 Brazilian Journal of Health Review; v. 6 n. 6 (2023); 30109-30122 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240038597066752 |