Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population

Detalhes bibliográficos
Autor(a) principal: Santos, Jéssica da Silva
Data de Publicação: 2023
Outros Autores: Rodrigues, Pedro Augusto Silva dos Santos, de Souza Junior, Denilson Luis Silva, Santos, Raphael Silva, Costa, Ryan dos Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Health Review
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191
Resumo: Depression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population.
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spelling Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population depressiongenetic variantsgenetic polymorphismantidepressantsDepression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-11-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6519110.34119/bjhrv6n6-270Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 30109-30122Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 30109-30122Brazilian Journal of Health Review; v. 6 n. 6 (2023); 30109-301222595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191/46648Santos, Jéssica da SilvaRodrigues, Pedro Augusto Silva dos Santosde Souza Junior, Denilson Luis SilvaSantos, Raphael SilvaCosta, Ryan dos Santosinfo:eu-repo/semantics/openAccess2023-12-01T12:26:45Zoai:ojs2.ojs.brazilianjournals.com.br:article/65191Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-12-01T12:26:45Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false
dc.title.none.fl_str_mv Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
title Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
spellingShingle Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
Santos, Jéssica da Silva
depression
genetic variants
genetic polymorphism
antidepressants
title_short Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
title_full Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
title_fullStr Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
title_full_unstemmed Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
title_sort Genetic variants used as predictors of response in the pharmacological treatment of depression in the brazilian population
author Santos, Jéssica da Silva
author_facet Santos, Jéssica da Silva
Rodrigues, Pedro Augusto Silva dos Santos
de Souza Junior, Denilson Luis Silva
Santos, Raphael Silva
Costa, Ryan dos Santos
author_role author
author2 Rodrigues, Pedro Augusto Silva dos Santos
de Souza Junior, Denilson Luis Silva
Santos, Raphael Silva
Costa, Ryan dos Santos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Jéssica da Silva
Rodrigues, Pedro Augusto Silva dos Santos
de Souza Junior, Denilson Luis Silva
Santos, Raphael Silva
Costa, Ryan dos Santos
dc.subject.por.fl_str_mv depression
genetic variants
genetic polymorphism
antidepressants
topic depression
genetic variants
genetic polymorphism
antidepressants
description Depression is one of the most frequent mental illnesses in the world and the lack of response to antidepressants are linked to genetic variants. The genetic diversity of Brazilian population may contribute to a variability in the response to these drugs, and this study aimed to assess how genetic variants are clinically and scientifically in the context of therapeutic response to depression in the Brazilian population. This work was carried out through a survey in literature and information obtained from genetic laboratories about the variants used in Brazil as biomarkers of response to antidepressants. Data from scientific studies published since 2000 that evaluated genetic variants that are related to the response to antidepressants in Brazilian populations, in the PubMed, Scielo, Scopus and Web of Science databases were also collected and compared with the international scenario. All laboratories evaluated included variants of CYP2D6 and CYP2C19 genes approved by Food and Drug Administration (FDA) as biomarkers. However, the Brazilian genetic panels include variants that lack proven efficacy in PharmGKB and are not FDA-approved, highlighting the need for more regulation of commercialized tests and further studies on genetic variant analysis for depression treatment in our population. A limited number of Brazilian studies in this field were verified, highlighting the need for more regulation of commercialized tests and further studies on genetic variant for depression treatment in our population.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191
10.34119/bjhrv6n6-270
url https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191
identifier_str_mv 10.34119/bjhrv6n6-270
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65191/46648
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 30109-30122
Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 30109-30122
Brazilian Journal of Health Review; v. 6 n. 6 (2023); 30109-30122
2595-6825
reponame:Brazilian Journal of Health Review
instname:Federação das Indústrias do Estado do Paraná (FIEP)
instacron:BJRH
instname_str Federação das Indústrias do Estado do Paraná (FIEP)
instacron_str BJRH
institution BJRH
reponame_str Brazilian Journal of Health Review
collection Brazilian Journal of Health Review
repository.name.fl_str_mv Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)
repository.mail.fl_str_mv || brazilianjhr@gmail.com
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