Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Brazilian Journal of Health Review |
| Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64955 |
Resumo: | The introduction of quinolonic antimicrobials on the market caused a revolution in antibacterial therapy. 4-quinolone skeleton became the target of many studies of structure-activity relationship establishing the parameters considered optimal for the development of new quinolonic antibiotics. These parameters limited the development of new compounds, so it is possible finding compounds with changes in the same position with similar substituents. The purpose of this article is to identify quinolonic compounds which do not fit into one or more criteria determined as ideal in the structure-activity relationship studies for quinolonic antibiotics and exemplify that it is possible to develop of even more active compounds making changes in previously unalterable positions. |
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Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugsquinoloneantibacterialstructure-activity relationshipThe introduction of quinolonic antimicrobials on the market caused a revolution in antibacterial therapy. 4-quinolone skeleton became the target of many studies of structure-activity relationship establishing the parameters considered optimal for the development of new quinolonic antibiotics. These parameters limited the development of new compounds, so it is possible finding compounds with changes in the same position with similar substituents. The purpose of this article is to identify quinolonic compounds which do not fit into one or more criteria determined as ideal in the structure-activity relationship studies for quinolonic antibiotics and exemplify that it is possible to develop of even more active compounds making changes in previously unalterable positions.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-11-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6495510.34119/bjhrv6n6-167Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 28702-28723Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 28702-28723Brazilian Journal of Health Review; v. 6 n. 6 (2023); 28702-287232595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64955/46511Nery, Ana Carolyne Sombrade Souza, Kátia ReginaDomingos, Jorge Luiz de Oliveirainfo:eu-repo/semantics/openAccess2023-11-20T20:12:17Zoai:ojs2.ojs.brazilianjournals.com.br:article/64955Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-11-20T20:12:17Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
| dc.title.none.fl_str_mv |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| title |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| spellingShingle |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs Nery, Ana Carolyne Sombra quinolone antibacterial structure-activity relationship |
| title_short |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| title_full |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| title_fullStr |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| title_full_unstemmed |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| title_sort |
Highlights on quinolonic compounds with changes on the basic structure as promising molecules to new drugs |
| author |
Nery, Ana Carolyne Sombra |
| author_facet |
Nery, Ana Carolyne Sombra de Souza, Kátia Regina Domingos, Jorge Luiz de Oliveira |
| author_role |
author |
| author2 |
de Souza, Kátia Regina Domingos, Jorge Luiz de Oliveira |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Nery, Ana Carolyne Sombra de Souza, Kátia Regina Domingos, Jorge Luiz de Oliveira |
| dc.subject.por.fl_str_mv |
quinolone antibacterial structure-activity relationship |
| topic |
quinolone antibacterial structure-activity relationship |
| description |
The introduction of quinolonic antimicrobials on the market caused a revolution in antibacterial therapy. 4-quinolone skeleton became the target of many studies of structure-activity relationship establishing the parameters considered optimal for the development of new quinolonic antibiotics. These parameters limited the development of new compounds, so it is possible finding compounds with changes in the same position with similar substituents. The purpose of this article is to identify quinolonic compounds which do not fit into one or more criteria determined as ideal in the structure-activity relationship studies for quinolonic antibiotics and exemplify that it is possible to develop of even more active compounds making changes in previously unalterable positions. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-20 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64955 10.34119/bjhrv6n6-167 |
| url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64955 |
| identifier_str_mv |
10.34119/bjhrv6n6-167 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64955/46511 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
| publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
| dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 28702-28723 Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 28702-28723 Brazilian Journal of Health Review; v. 6 n. 6 (2023); 28702-28723 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
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Federação das Indústrias do Estado do Paraná (FIEP) |
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BJRH |
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BJRH |
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Brazilian Journal of Health Review |
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Brazilian Journal of Health Review |
| repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
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|| brazilianjhr@gmail.com |
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1797240038041321472 |