Methodology of trace metals analysis in reference, generic and similar medicines: a comparison / Metodologia da análise de metais trace em medicamentos de referência, genéricos e semelhantes: uma comparação

• Autor(a) principal: Santos, Suzana O.
• Data de Publicação: 2019
• Outros Autores: Souza, Vivianne L. B de, Amaral, Romiton dos S., Soares, Andre Luiz, Barbosa, Sandra Dias
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Health Review
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/3156
• topic: drugs; trace elements; contamination in production.

Trace metals are, among the toxic substances, some that cause intoxication of the human organism, they are highly reactive and bioaccumulative; however, living things require small amounts of some metals, including Co, Cu, Mn, Mo, V, Sr and Zn to perform vital functions. Other metals such as mercury, lead and cadmium, have no function to organic systems, and their accumulation may cause several pathologies. Trace metals are also part of pharmaceutical preparations found as contaminants from machinery, handling or medicinal plants’ extracts. The presence of metals in medicines has become a relevant subject to evaluate the degree of exposure and possible consequences for human health. The aim of the work being carried out at the Northeastern Regional Center for Nuclear Sciences in conjunction with the Department of Nuclear Energy is to obtain a qualitative and quantitative analysis of trace metals in medicines and comparing with specific parameters of the Brazilian Legislation. To help regulatory agencies to have a greater control of medicines sold based on the elaborated methodology.