Effects of selenium supplementation on oxidative stress in the brain
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839 |
Resumo: | Selenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern. Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers. Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response. |
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Brazilian Journal of Health Review |
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Effects of selenium supplementation on oxidative stress in the brainbrain alteration neurology oxidative stressseleniumselenium supplementationSelenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern. Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers. Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-12-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6583910.34119/bjhrv6n6-498Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 33028-33038Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 33028-33038Brazilian Journal of Health Review; v. 6 n. 6 (2023); 33028-330382595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839/47021Sayed, Omar ElGomes, Luisa Pereira de Oliveira ZanettiMartins, Camila MarinelliKozu, Adriana Yuriko KogaLipinski, Leandro CavalcanteGomes, Ricardo ZanettiHofmann, Rafaelde Carvalho, Phelipe Paiminfo:eu-repo/semantics/openAccess2023-12-21T19:00:02Zoai:ojs2.ojs.brazilianjournals.com.br:article/65839Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-12-21T19:00:02Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Effects of selenium supplementation on oxidative stress in the brain |
title |
Effects of selenium supplementation on oxidative stress in the brain |
spellingShingle |
Effects of selenium supplementation on oxidative stress in the brain Sayed, Omar El brain alteration neurology oxidative stress selenium selenium supplementation |
title_short |
Effects of selenium supplementation on oxidative stress in the brain |
title_full |
Effects of selenium supplementation on oxidative stress in the brain |
title_fullStr |
Effects of selenium supplementation on oxidative stress in the brain |
title_full_unstemmed |
Effects of selenium supplementation on oxidative stress in the brain |
title_sort |
Effects of selenium supplementation on oxidative stress in the brain |
author |
Sayed, Omar El |
author_facet |
Sayed, Omar El Gomes, Luisa Pereira de Oliveira Zanetti Martins, Camila Marinelli Kozu, Adriana Yuriko Koga Lipinski, Leandro Cavalcante Gomes, Ricardo Zanetti Hofmann, Rafael de Carvalho, Phelipe Paim |
author_role |
author |
author2 |
Gomes, Luisa Pereira de Oliveira Zanetti Martins, Camila Marinelli Kozu, Adriana Yuriko Koga Lipinski, Leandro Cavalcante Gomes, Ricardo Zanetti Hofmann, Rafael de Carvalho, Phelipe Paim |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Sayed, Omar El Gomes, Luisa Pereira de Oliveira Zanetti Martins, Camila Marinelli Kozu, Adriana Yuriko Koga Lipinski, Leandro Cavalcante Gomes, Ricardo Zanetti Hofmann, Rafael de Carvalho, Phelipe Paim |
dc.subject.por.fl_str_mv |
brain alteration neurology oxidative stress selenium selenium supplementation |
topic |
brain alteration neurology oxidative stress selenium selenium supplementation |
description |
Selenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern. Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers. Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839 10.34119/bjhrv6n6-498 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839 |
identifier_str_mv |
10.34119/bjhrv6n6-498 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839/47021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 33028-33038 Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 33028-33038 Brazilian Journal of Health Review; v. 6 n. 6 (2023); 33028-33038 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240039965458432 |