Effects of selenium supplementation on oxidative stress in the brain

Detalhes bibliográficos
Autor(a) principal: Sayed, Omar El
Data de Publicação: 2023
Outros Autores: Gomes, Luisa Pereira de Oliveira Zanetti, Martins, Camila Marinelli, Kozu, Adriana Yuriko Koga, Lipinski, Leandro Cavalcante, Gomes, Ricardo Zanetti, Hofmann, Rafael, de Carvalho, Phelipe Paim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Health Review
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839
Resumo: Selenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern.  Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers.  Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response.
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spelling Effects of selenium supplementation on oxidative stress in the brainbrain alteration neurology oxidative stressseleniumselenium supplementationSelenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern.  Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers.  Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-12-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6583910.34119/bjhrv6n6-498Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 33028-33038Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 33028-33038Brazilian Journal of Health Review; v. 6 n. 6 (2023); 33028-330382595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839/47021Sayed, Omar ElGomes, Luisa Pereira de Oliveira ZanettiMartins, Camila MarinelliKozu, Adriana Yuriko KogaLipinski, Leandro CavalcanteGomes, Ricardo ZanettiHofmann, Rafaelde Carvalho, Phelipe Paiminfo:eu-repo/semantics/openAccess2023-12-21T19:00:02Zoai:ojs2.ojs.brazilianjournals.com.br:article/65839Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-12-21T19:00:02Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false
dc.title.none.fl_str_mv Effects of selenium supplementation on oxidative stress in the brain
title Effects of selenium supplementation on oxidative stress in the brain
spellingShingle Effects of selenium supplementation on oxidative stress in the brain
Sayed, Omar El
brain alteration neurology oxidative stress
selenium
selenium supplementation
title_short Effects of selenium supplementation on oxidative stress in the brain
title_full Effects of selenium supplementation on oxidative stress in the brain
title_fullStr Effects of selenium supplementation on oxidative stress in the brain
title_full_unstemmed Effects of selenium supplementation on oxidative stress in the brain
title_sort Effects of selenium supplementation on oxidative stress in the brain
author Sayed, Omar El
author_facet Sayed, Omar El
Gomes, Luisa Pereira de Oliveira Zanetti
Martins, Camila Marinelli
Kozu, Adriana Yuriko Koga
Lipinski, Leandro Cavalcante
Gomes, Ricardo Zanetti
Hofmann, Rafael
de Carvalho, Phelipe Paim
author_role author
author2 Gomes, Luisa Pereira de Oliveira Zanetti
Martins, Camila Marinelli
Kozu, Adriana Yuriko Koga
Lipinski, Leandro Cavalcante
Gomes, Ricardo Zanetti
Hofmann, Rafael
de Carvalho, Phelipe Paim
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sayed, Omar El
Gomes, Luisa Pereira de Oliveira Zanetti
Martins, Camila Marinelli
Kozu, Adriana Yuriko Koga
Lipinski, Leandro Cavalcante
Gomes, Ricardo Zanetti
Hofmann, Rafael
de Carvalho, Phelipe Paim
dc.subject.por.fl_str_mv brain alteration neurology oxidative stress
selenium
selenium supplementation
topic brain alteration neurology oxidative stress
selenium
selenium supplementation
description Selenium is known to produce great effect on the oxidative stress of cells, both systemic and cerebral. Brain degeneration occurs as a result of several factors, one of them is the oxidative stress. We aim To analyze selenium effect on rats’ brains, investigating serum and immunohistochemical oxidative stress markers, and the neural structural pattern.  Selenium supplementation with 48 μg chelated selenium and with 96 μg chelated selenium for 60 days, followed by an evaluation of oxidative stress markers, as well as immunohistochemical markers.  Lower TBARS was observed in the rats subjected to 44mcg Se supplementation when compared to the other groups. Among the other oxidative stress markers, and immunohistochemical markers, little variation was observed. Improvement was observed in TBARS levels. However, the other measurements showed little statistical relevance. This raises some questioning regarding the dose used or the formulation and its bioavailability as influential factors in the oxidative response.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839
10.34119/bjhrv6n6-498
url https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839
identifier_str_mv 10.34119/bjhrv6n6-498
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/65839/47021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 33028-33038
Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 33028-33038
Brazilian Journal of Health Review; v. 6 n. 6 (2023); 33028-33038
2595-6825
reponame:Brazilian Journal of Health Review
instname:Federação das Indústrias do Estado do Paraná (FIEP)
instacron:BJRH
instname_str Federação das Indústrias do Estado do Paraná (FIEP)
instacron_str BJRH
institution BJRH
reponame_str Brazilian Journal of Health Review
collection Brazilian Journal of Health Review
repository.name.fl_str_mv Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)
repository.mail.fl_str_mv || brazilianjhr@gmail.com
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