Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64899 |
Resumo: | To assess serum vitamin D levels in patients with breast cancer and compare them against control patients without the disease, testing the hypothesis that patients with breast cancer have lower serum levels of the hormone than patients without the cancer. A total of 101 treatment-naïve patients diagnosed with breast cancer at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology of the Irmandade da Santa Casa de São Paulo (ISCMSP), and 100 control patients without the disease at the Endocrinologic Gynecology Outpatient Clinic of the same institution were selected. Serum vitamin D levels for the two groups were compared. Mean serum vitamin D level was 23.85 ng/dL in the breast cancer group versus 28.19 ng/dL in the control group, where this difference proved statistically significant on Student´s t-test (p=0.002). Patient age was a confounding bias, where no correlation between serum level and age was evident on the scatter plot. Patients with breast cancer had lower serum Vitamin D levels than patients without the cancer. However, longitudinal studies should be conducted to determine whether a causal relationship exists between these variables. |
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Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional studyvitamin Dbreast neoplasmscalcitriolcarcinogenesismetabolismTo assess serum vitamin D levels in patients with breast cancer and compare them against control patients without the disease, testing the hypothesis that patients with breast cancer have lower serum levels of the hormone than patients without the cancer. A total of 101 treatment-naïve patients diagnosed with breast cancer at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology of the Irmandade da Santa Casa de São Paulo (ISCMSP), and 100 control patients without the disease at the Endocrinologic Gynecology Outpatient Clinic of the same institution were selected. Serum vitamin D levels for the two groups were compared. Mean serum vitamin D level was 23.85 ng/dL in the breast cancer group versus 28.19 ng/dL in the control group, where this difference proved statistically significant on Student´s t-test (p=0.002). Patient age was a confounding bias, where no correlation between serum level and age was evident on the scatter plot. Patients with breast cancer had lower serum Vitamin D levels than patients without the cancer. However, longitudinal studies should be conducted to determine whether a causal relationship exists between these variables.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-11-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6489910.34119/bjhrv6n6-150Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 28465-28472Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 28465-28472Brazilian Journal of Health Review; v. 6 n. 6 (2023); 28465-284722595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64899/46475Lucarelli, Adrienne PratiMartins, Maria Martainfo:eu-repo/semantics/openAccess2023-11-18T19:02:59Zoai:ojs2.ojs.brazilianjournals.com.br:article/64899Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-11-18T19:02:59Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
title |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
spellingShingle |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study Lucarelli, Adrienne Prati vitamin D breast neoplasms calcitriol carcinogenesis metabolism |
title_short |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
title_full |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
title_fullStr |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
title_full_unstemmed |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
title_sort |
Comparison of 25-hydroxyvitamin D levels in breast cancer patients and control group: a cross-sectional study |
author |
Lucarelli, Adrienne Prati |
author_facet |
Lucarelli, Adrienne Prati Martins, Maria Marta |
author_role |
author |
author2 |
Martins, Maria Marta |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Lucarelli, Adrienne Prati Martins, Maria Marta |
dc.subject.por.fl_str_mv |
vitamin D breast neoplasms calcitriol carcinogenesis metabolism |
topic |
vitamin D breast neoplasms calcitriol carcinogenesis metabolism |
description |
To assess serum vitamin D levels in patients with breast cancer and compare them against control patients without the disease, testing the hypothesis that patients with breast cancer have lower serum levels of the hormone than patients without the cancer. A total of 101 treatment-naïve patients diagnosed with breast cancer at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology of the Irmandade da Santa Casa de São Paulo (ISCMSP), and 100 control patients without the disease at the Endocrinologic Gynecology Outpatient Clinic of the same institution were selected. Serum vitamin D levels for the two groups were compared. Mean serum vitamin D level was 23.85 ng/dL in the breast cancer group versus 28.19 ng/dL in the control group, where this difference proved statistically significant on Student´s t-test (p=0.002). Patient age was a confounding bias, where no correlation between serum level and age was evident on the scatter plot. Patients with breast cancer had lower serum Vitamin D levels than patients without the cancer. However, longitudinal studies should be conducted to determine whether a causal relationship exists between these variables. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64899 10.34119/bjhrv6n6-150 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64899 |
identifier_str_mv |
10.34119/bjhrv6n6-150 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/64899/46475 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 6 (2023); 28465-28472 Brazilian Journal of Health Review; Vol. 6 Núm. 6 (2023); 28465-28472 Brazilian Journal of Health Review; v. 6 n. 6 (2023); 28465-28472 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240038005669888 |