Improvement of Anxiety, Depression and fatigue after treatment of Anemia in patients with inflammatory bowel disease patients: Melhora da Ansiedade, Depressão e fadiga após tratamento de Anemia em pacientes com doença inflamatória intestinal

• Autor(a) principal: Antunes, Tatiane de Alvarenga
• Data de Publicação: 2022
• Outros Autores: Antunes, Priscila de Alvarenga, Nascimento, Bruno Kappel, Zanini, Angelo Tabet, Pinheiro, Jossiely Rodrigues, Azevedo, Maria Cláudia Ferreira Bezerra de, Nascimento, Cristiano Rodrigo de Alvarenga, Antunes, Carla Valéria de Alvarenga
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Health Review
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/51650
• topic: inflammatory bowel disease; Anemia; ulcerative colitis; Crohn’s disease; quality of life; fatigue; Anxiety; Depression

INTRODUCTION: Anemia is a common complication in inflammatory disease bowel (IBD). Many patients have this comorbidity ignored during clinical follow-up. Nonetheless, studies of anemic patients have a significant relationship between anemia and higher anxiety, depression and fatigue. This study evaluated the level of anxiety, depression and fatigue before and after treatment for anemia in mild anemic, IBD patients from the IBD Center of the UFJF University Hospital. OBJECTIVE: The objective of the present study was to investigate the improvement of anxiety, depression and fatigue after treatment of anemia in IBD patients. METHODS: In this cross-sectional study, 100 patients with CD (Crohn's disease) and 100 with RCUI (ulcerative colitis) were screened for anemia. For evaluation of anemia, complete blood count, ferritin, saturation index transferrin, serum levels of folic acid, serum iron and vitamin B12 was performed. In anemic patients, was evaluated and compared the levels of anxiety, depression and fatigue before and after anemia treatment. For the evaluation of anxiety was applied the hospital anxiety and depression scale (HADS), to assess fatigue was applied Chalder`s questionnaire. RESULTS: The evaluation average for anxiety before anemia treatment was 7.3 ± 4.3 and after treatment it was 5.3 ± 4.8 (p=0.0.08), the average of depression before treatment was 6.2 ± 5.2 and after treatment it was 4.9 ± 4.8 (p=0.08) and the average of fatigue before anemia treatment was 30.9 ± 8.7 and after treatment it was 21.6 ± 8.4 (p<0.001). Treatment with oral liposomal iron was effective in improving mild IDA and quality of life, as well as in decreasing fatigue in patients with inactive or mildly active IBD. CONCLUSION: The treatment of anemia in patients with IBD Brazilian outpatients showed statistically significant improvement in cases of anxiety and fatigue, although did not demonstrate a significant improvement in depression.