Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008 |
Resumo: | Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs. |
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Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin AmericaCryptococcal meningitisCryptococccosisEpidemiologyDiagnosisTreatmentMortalityLatin AmericaLatin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs.Brazilian Society of Infectious Diseases2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008Brazilian Journal of Infectious Diseases v.17 n.3 2013reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2012.10.020info:eu-repo/semantics/openAccessVidal,Jose E.Oliveira,Augusto C. Penalva deDauar,Rafi F.Boulware,David R.eng2013-06-13T00:00:00Zoai:scielo:S1413-86702013000300008Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2013-06-13T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
title |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
spellingShingle |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America Vidal,Jose E. Cryptococcal meningitis Cryptococccosis Epidemiology Diagnosis Treatment Mortality Latin America |
title_short |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
title_full |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
title_fullStr |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
title_full_unstemmed |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
title_sort |
Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America |
author |
Vidal,Jose E. |
author_facet |
Vidal,Jose E. Oliveira,Augusto C. Penalva de Dauar,Rafi F. Boulware,David R. |
author_role |
author |
author2 |
Oliveira,Augusto C. Penalva de Dauar,Rafi F. Boulware,David R. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Vidal,Jose E. Oliveira,Augusto C. Penalva de Dauar,Rafi F. Boulware,David R. |
dc.subject.por.fl_str_mv |
Cryptococcal meningitis Cryptococccosis Epidemiology Diagnosis Treatment Mortality Latin America |
topic |
Cryptococcal meningitis Cryptococccosis Epidemiology Diagnosis Treatment Mortality Latin America |
description |
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of intracranial pressure and induction therapy with antifungal combination. Implementation of these strategies can reduce cryptococcal-related deaths, improve care, and reduce healthcare costs. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2012.10.020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.17 n.3 2013 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209242468843520 |