Disease burden of chronic hepatitis C in Brazil

Detalhes bibliográficos
Autor(a) principal: Ferreira,Paulo Roberto Abrão
Data de Publicação: 2015
Outros Autores: Brandão-Mello,Carlos Eduardo, Estes,Chris, Gonçales Júnior,Fernando Lopes, Coelho,Henrique Sérgio Moraes, Razavi,Homie, Cheinquer,Hugo, Wolff,Fernando Herz, Ferraz,Maria Lúcia Gomes, Pessoa,Mário Guimarães, Mendes-Correa,Maria Cássia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363
Resumo: Background: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).Results: The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals); while the number of cases of compensated (n= 325,900) and decompen- sated (n= 45,000) cirrhosis; hepatocellular carcinoma (n= 19,100); and liver-related deaths (n= 16,700) is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated) as compared to 2013 (11,740 treated); with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.Conclusions: While the incidence and prevalence of hepatitis C virus in Brazil are decreasing; cases of advanced liver disease continue to rise. Besides higher sustained virological response rates; new strategies focused on increasing the proportion of diagnosed patients and eligibility to treatment should be adopted in order to reduce the burden of hepatitis C virus infection in Brazil.
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spelling Disease burden of chronic hepatitis C in BrazilHCVDisease burdenEpidemiologyIncidenceBrazilBackground: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).Results: The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals); while the number of cases of compensated (n= 325,900) and decompen- sated (n= 45,000) cirrhosis; hepatocellular carcinoma (n= 19,100); and liver-related deaths (n= 16,700) is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated) as compared to 2013 (11,740 treated); with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.Conclusions: While the incidence and prevalence of hepatitis C virus in Brazil are decreasing; cases of advanced liver disease continue to rise. Besides higher sustained virological response rates; new strategies focused on increasing the proportion of diagnosed patients and eligibility to treatment should be adopted in order to reduce the burden of hepatitis C virus infection in Brazil.Brazilian Society of Infectious Diseases2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363Brazilian Journal of Infectious Diseases v.19 n.4 2015reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2015.04.004info:eu-repo/semantics/openAccessFerreira,Paulo Roberto AbrãoBrandão-Mello,Carlos EduardoEstes,ChrisGonçales Júnior,Fernando LopesCoelho,Henrique Sérgio MoraesRazavi,HomieCheinquer,HugoWolff,Fernando HerzFerraz,Maria Lúcia GomesPessoa,Mário GuimarãesMendes-Correa,Maria Cássiaeng2015-09-09T00:00:00Zoai:scielo:S1413-86702015000400363Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2015-09-09T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Disease burden of chronic hepatitis C in Brazil
title Disease burden of chronic hepatitis C in Brazil
spellingShingle Disease burden of chronic hepatitis C in Brazil
Ferreira,Paulo Roberto Abrão
HCV
Disease burden
Epidemiology
Incidence
Brazil
title_short Disease burden of chronic hepatitis C in Brazil
title_full Disease burden of chronic hepatitis C in Brazil
title_fullStr Disease burden of chronic hepatitis C in Brazil
title_full_unstemmed Disease burden of chronic hepatitis C in Brazil
title_sort Disease burden of chronic hepatitis C in Brazil
author Ferreira,Paulo Roberto Abrão
author_facet Ferreira,Paulo Roberto Abrão
Brandão-Mello,Carlos Eduardo
Estes,Chris
Gonçales Júnior,Fernando Lopes
Coelho,Henrique Sérgio Moraes
Razavi,Homie
Cheinquer,Hugo
Wolff,Fernando Herz
Ferraz,Maria Lúcia Gomes
Pessoa,Mário Guimarães
Mendes-Correa,Maria Cássia
author_role author
author2 Brandão-Mello,Carlos Eduardo
Estes,Chris
Gonçales Júnior,Fernando Lopes
Coelho,Henrique Sérgio Moraes
Razavi,Homie
Cheinquer,Hugo
Wolff,Fernando Herz
Ferraz,Maria Lúcia Gomes
Pessoa,Mário Guimarães
Mendes-Correa,Maria Cássia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira,Paulo Roberto Abrão
Brandão-Mello,Carlos Eduardo
Estes,Chris
Gonçales Júnior,Fernando Lopes
Coelho,Henrique Sérgio Moraes
Razavi,Homie
Cheinquer,Hugo
Wolff,Fernando Herz
Ferraz,Maria Lúcia Gomes
Pessoa,Mário Guimarães
Mendes-Correa,Maria Cássia
dc.subject.por.fl_str_mv HCV
Disease burden
Epidemiology
Incidence
Brazil
topic HCV
Disease burden
Epidemiology
Incidence
Brazil
description Background: Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.Methods: Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).Results: The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals); while the number of cases of compensated (n= 325,900) and decompen- sated (n= 45,000) cirrhosis; hepatocellular carcinoma (n= 19,100); and liver-related deaths (n= 16,700) is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated) as compared to 2013 (11,740 treated); with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.Conclusions: While the incidence and prevalence of hepatitis C virus in Brazil are decreasing; cases of advanced liver disease continue to rise. Besides higher sustained virological response rates; new strategies focused on increasing the proportion of diagnosed patients and eligibility to treatment should be adopted in order to reduce the burden of hepatitis C virus infection in Brazil.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400363
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2015.04.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.19 n.4 2015
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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