The impact of dengue on liver function as evaluated by aminotransferase levels
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007 |
Resumo: | The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases. |
id |
BSID-1_3274341e7d84b19785baeec7aea2a25f |
---|---|
oai_identifier_str |
oai:scielo:S1413-86702007000400007 |
network_acronym_str |
BSID-1 |
network_name_str |
Brazilian Journal of Infectious Diseases |
repository_id_str |
|
spelling |
The impact of dengue on liver function as evaluated by aminotransferase levelsDenguedengue hemorrhagic feveraminotransferaseshepatitisThe objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.Brazilian Society of Infectious Diseases2007-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007Brazilian Journal of Infectious Diseases v.11 n.4 2007reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702007000400007info:eu-repo/semantics/openAccessSouza,Luiz José deNogueira,Rita Maria RibeiroSoares,Leandro CordeiroSoares,Carlos Eduardo CordeiroRibas,Bruno FernandesAlves,Felipe PintoVieira,Fabíola RodriguesPessanha,Felipe Eulálio Baldieng2007-09-03T00:00:00Zoai:scielo:S1413-86702007000400007Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2007-09-03T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
The impact of dengue on liver function as evaluated by aminotransferase levels |
title |
The impact of dengue on liver function as evaluated by aminotransferase levels |
spellingShingle |
The impact of dengue on liver function as evaluated by aminotransferase levels Souza,Luiz José de Dengue dengue hemorrhagic fever aminotransferases hepatitis |
title_short |
The impact of dengue on liver function as evaluated by aminotransferase levels |
title_full |
The impact of dengue on liver function as evaluated by aminotransferase levels |
title_fullStr |
The impact of dengue on liver function as evaluated by aminotransferase levels |
title_full_unstemmed |
The impact of dengue on liver function as evaluated by aminotransferase levels |
title_sort |
The impact of dengue on liver function as evaluated by aminotransferase levels |
author |
Souza,Luiz José de |
author_facet |
Souza,Luiz José de Nogueira,Rita Maria Ribeiro Soares,Leandro Cordeiro Soares,Carlos Eduardo Cordeiro Ribas,Bruno Fernandes Alves,Felipe Pinto Vieira,Fabíola Rodrigues Pessanha,Felipe Eulálio Baldi |
author_role |
author |
author2 |
Nogueira,Rita Maria Ribeiro Soares,Leandro Cordeiro Soares,Carlos Eduardo Cordeiro Ribas,Bruno Fernandes Alves,Felipe Pinto Vieira,Fabíola Rodrigues Pessanha,Felipe Eulálio Baldi |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Souza,Luiz José de Nogueira,Rita Maria Ribeiro Soares,Leandro Cordeiro Soares,Carlos Eduardo Cordeiro Ribas,Bruno Fernandes Alves,Felipe Pinto Vieira,Fabíola Rodrigues Pessanha,Felipe Eulálio Baldi |
dc.subject.por.fl_str_mv |
Dengue dengue hemorrhagic fever aminotransferases hepatitis |
topic |
Dengue dengue hemorrhagic fever aminotransferases hepatitis |
description |
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702007000400007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.11 n.4 2007 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209239890395136 |