The impact of dengue on liver function as evaluated by aminotransferase levels

Detalhes bibliográficos
Autor(a) principal: Souza,Luiz José de
Data de Publicação: 2007
Outros Autores: Nogueira,Rita Maria Ribeiro, Soares,Leandro Cordeiro, Soares,Carlos Eduardo Cordeiro, Ribas,Bruno Fernandes, Alves,Felipe Pinto, Vieira,Fabíola Rodrigues, Pessanha,Felipe Eulálio Baldi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007
Resumo: The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
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spelling The impact of dengue on liver function as evaluated by aminotransferase levelsDenguedengue hemorrhagic feveraminotransferaseshepatitisThe objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.Brazilian Society of Infectious Diseases2007-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007Brazilian Journal of Infectious Diseases v.11 n.4 2007reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702007000400007info:eu-repo/semantics/openAccessSouza,Luiz José deNogueira,Rita Maria RibeiroSoares,Leandro CordeiroSoares,Carlos Eduardo CordeiroRibas,Bruno FernandesAlves,Felipe PintoVieira,Fabíola RodriguesPessanha,Felipe Eulálio Baldieng2007-09-03T00:00:00Zoai:scielo:S1413-86702007000400007Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2007-09-03T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv The impact of dengue on liver function as evaluated by aminotransferase levels
title The impact of dengue on liver function as evaluated by aminotransferase levels
spellingShingle The impact of dengue on liver function as evaluated by aminotransferase levels
Souza,Luiz José de
Dengue
dengue hemorrhagic fever
aminotransferases
hepatitis
title_short The impact of dengue on liver function as evaluated by aminotransferase levels
title_full The impact of dengue on liver function as evaluated by aminotransferase levels
title_fullStr The impact of dengue on liver function as evaluated by aminotransferase levels
title_full_unstemmed The impact of dengue on liver function as evaluated by aminotransferase levels
title_sort The impact of dengue on liver function as evaluated by aminotransferase levels
author Souza,Luiz José de
author_facet Souza,Luiz José de
Nogueira,Rita Maria Ribeiro
Soares,Leandro Cordeiro
Soares,Carlos Eduardo Cordeiro
Ribas,Bruno Fernandes
Alves,Felipe Pinto
Vieira,Fabíola Rodrigues
Pessanha,Felipe Eulálio Baldi
author_role author
author2 Nogueira,Rita Maria Ribeiro
Soares,Leandro Cordeiro
Soares,Carlos Eduardo Cordeiro
Ribas,Bruno Fernandes
Alves,Felipe Pinto
Vieira,Fabíola Rodrigues
Pessanha,Felipe Eulálio Baldi
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza,Luiz José de
Nogueira,Rita Maria Ribeiro
Soares,Leandro Cordeiro
Soares,Carlos Eduardo Cordeiro
Ribas,Bruno Fernandes
Alves,Felipe Pinto
Vieira,Fabíola Rodrigues
Pessanha,Felipe Eulálio Baldi
dc.subject.por.fl_str_mv Dengue
dengue hemorrhagic fever
aminotransferases
hepatitis
topic Dengue
dengue hemorrhagic fever
aminotransferases
hepatitis
description The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
publishDate 2007
dc.date.none.fl_str_mv 2007-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702007000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.11 n.4 2007
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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