Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017 |
Resumo: | Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance. |
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Brazilian Journal of Infectious Diseases |
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Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazilhepatitis Cchronichearing losssuddeninterferon-alphaSudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance.Brazilian Society of Infectious Diseases2011-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017Brazilian Journal of Infectious Diseases v.15 n.1 2011reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702011000100017info:eu-repo/semantics/openAccessMendes-Corrêa,Maria Cassia JacinthoBittar,Roseli Saraiva MoreiraSalmito,NormaOiticica,Jeanneeng2011-03-02T00:00:00Zoai:scielo:S1413-86702011000100017Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2011-03-02T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
title |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
spellingShingle |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil Mendes-Corrêa,Maria Cassia Jacintho hepatitis C chronic hearing loss sudden interferon-alpha |
title_short |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
title_full |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
title_fullStr |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
title_full_unstemmed |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
title_sort |
Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil |
author |
Mendes-Corrêa,Maria Cassia Jacintho |
author_facet |
Mendes-Corrêa,Maria Cassia Jacintho Bittar,Roseli Saraiva Moreira Salmito,Norma Oiticica,Jeanne |
author_role |
author |
author2 |
Bittar,Roseli Saraiva Moreira Salmito,Norma Oiticica,Jeanne |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Mendes-Corrêa,Maria Cassia Jacintho Bittar,Roseli Saraiva Moreira Salmito,Norma Oiticica,Jeanne |
dc.subject.por.fl_str_mv |
hepatitis C chronic hearing loss sudden interferon-alpha |
topic |
hepatitis C chronic hearing loss sudden interferon-alpha |
description |
Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon-alpha and ribavirin for chronic hepatitis C. Peginterferon and ribavirin may cause sudden hearing loss that may not recover after discontinuation of therapy. Immediate treatment for all possible etiologies is essential, along with targeted investigations and early referral for an Ear, Nose and Throat specialist. Physicians should be aware of the possible ototoxic effects of peginterferon and ribavirin combination therapy requiring appropriate surveillance. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702011000100017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.15 n.1 2011 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209241561825280 |