Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective

• Autor(a) principal: Riccetto,Adriana Gut Lopes
• Data de Publicação: 2009
• Outros Autores: Silva,Luciana Helena Antoniassi da, Spilki,Fernando Rosado, Morcillo,André Moreno, Arns,Clarice Weis, Baracat,Emílio Carlos Elias
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Infectious Diseases
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100008
• topic: Respiratory syncytial virus; metapneumovirus; genotypes; infants; clinical

The aim of this study was to determine if there was a correlation between respiratory syncytial virus (RSV) and metapneumovirus (MPV) genotypes and clinical data of Brazilian infants hospitalized for acute lower respiratory infection. The viruses in the patients' nasopharyngeal secretions were studied using the polymerase chain reaction and phylogenetic analysis. The study assessed 144 infants; 31.9% were RSV positive and 5.6% were MPV positive. Statistical analysis was performed using the chi-squared test, Fisher's test, Odds ratio, univariate logistic regression, non-conditional multivariate logistic regression and the forward - stepwise method. Multivariate analysis confirmed a significant relationship between a positive PCR test for RSV and hospitalization during the month of May and with pulse oximetry less than 90%. The phylogenetic analysis indicated the genotypes GA2, GA5, SAA1 (Group A), SAB1, SAB3 and BA (Group B) for RSV and Group B, subgroup B1, for MPV.